The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Fluid shear stress activates YAP1 to promote cancer cell motility
Open accessAbstract
Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid wall shear stress (WSS) typical of venous or arterial flow inhibit taxis. YAP1, but not TAZ, is strictly required for WSS-enhanced cell movement, as blockade of YAP1 , TEAD1-4 or the YAP1–TEAD interaction reduces cellular velocity to levels observed without flow. Silencing of TEAD phenocopies loss of YAP1, implicating transcriptional transactivation function in mediating force-enhanced cell migration. WSS dictates expression of a network of YAP1 effectors with executive roles in invasion, chemotaxis and adhesion downstream of the ROCK–LIMK–cofilin signalling axis. Altogether, these data implicate YAP1 as a fluid mechanosensor that functions to regulate genes that promote metastasis.
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2 retracted
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RetractedProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
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RetractedRole of YAP/TAZ in mechanotransduction
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Soft Lithography in Biology and Biochemistry
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Focal adhesion kinase: in command and control of cell motility.
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A tense situation: forcing tumour progression
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Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
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Cited by
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Regulation of TEAD Transcription Factors in Cancer Biology
Huh, H., Kim, D., Jeong, H.-S., & Park, H. (2019) · Cells · doi:10.3390/cells8060600 · Cited by 259
Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells
Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146
Metadata
- Authors
- Lee, H. J., Diaz, M. F., Price, K. M., Ozuna, J. A., Zhang, S., Sevick-Muraca, E. M., Hagan, J. P., & Wenzel, P. L.
- Venue
- Nature Communications
- Published
- 2017-01-18
- Volume
- 8
- Issue
- 1
- Pages
- 14122-14122
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2572990295
- Cited by
- 258
- References
- 64
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lee, H. J., Diaz, M. F., Price, K. M., Ozuna, J. A., Zhang, S., Sevick-Muraca, E. M., Hagan, J. P., & Wenzel, P. L. (2017). Fluid shear stress activates YAP1 to promote cancer cell motility. Nature Communications. https://doi.org/10.1038/ncomms14122
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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