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Focal adhesion kinase: in command and control of cell motility.

Mitra, Satyajit K., Hanson, Daniel A., Schlaepfer, David D.·2005·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm1549
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Abstract

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.

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Metadata

Authors
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2005-01-01
Volume
6
Issue
1
Pages
56-68
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm1549
Cited by
2,335
References
3
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Focal adhesion kinase: in command and control of cell motility. https://app.cochat.ai/papers/10.1038/nrm1549
The paper
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005). Focal adhesion kinase: in command and control of cell motility. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm1549