The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chirality detection of enantiomers using twisted optical metamaterials
Open accessAbstract
Many naturally occurring biomolecules, such as amino acids, sugars and nucleotides, are inherently chiral. Enantiomers, a pair of chiral isomers with opposite handedness, often exhibit similar physical and chemical properties due to their identical functional groups and composition, yet show different toxicity to cells. Detecting enantiomers in small quantities has an essential role in drug development to eliminate their unwanted side effects. Here we exploit strong chiral interactions with plasmonic metamaterials with specifically designed optical response to sense chiral molecules down to zeptomole levels, several orders of magnitude smaller than what is typically detectable with conventional circular dichroism spectroscopy. In particular, the measured spectra reveal opposite signs in the spectral regime directly associated with different chiral responses, providing a way to univocally assess molecular chirality. Our work introduces an ultrathin, planarized nanophotonic interface to sense chiral molecules with inherently weak circular dichroism at visible and near-infrared frequencies.
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Cites
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Optical vortices 30 years on: OAM manipulation from topological charge to multiple singularities
Shen, Y., Wang, X., Xie, Z., Min, C., Fu, X., Liu, Q., Gong, M., & Yuan, X. (2019) · Light: Science & Applications · doi:10.1038/s41377-019-0194-2 · Cited by 2,219
Electromagnetic chirality: from fundamentals to nontraditional chiroptical phenomena
Mun, J., Kim, M., Yang, Y., Badloe, T., Ni, J., Chen, Y., Qiu, C.-W., & Rho, J. (2020) · Light: Science & Applications · doi:10.1038/s41377-020-00367-8 · Cited by 573
Plasmonic Biosensing: Focus Review
Mejía-Salazar, J. R., & Oliveira, O. N. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00359 · Cited by 544
Ha, M., Kim, J.-H., You, M., Li, Q., Fan, C., & Nam, J.-M. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00234 · Cited by 466
Qiu, C.-W., Zhang, T., Hu, G., & Kivshar, Y. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00828 · Cited by 243
Metadata
- Authors
- Zhao, Y., Askarpour, A. N., Sun, L., Shi, J., Li, X., & Alù, A.
- Venue
- Nature Communications
- Published
- 2017-01-25
- Volume
- 8
- Issue
- 1
- Pages
- 14180-14180
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2580678987
- Cited by
- 622
- References
- 33
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhao, Y., Askarpour, A. N., Sun, L., Shi, J., Li, X., & Alù, A. (2017). Chirality detection of enantiomers using twisted optical metamaterials. Nature Communications. https://doi.org/10.1038/ncomms14180
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