The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Blimp1 regulates the transition of neonatal to adult intestinal epithelium
Open accessAbstract
In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation. Many mammals are born with an immature intestinal epithelium, which adapts to a changing diet during the weaning period. Muncanet al. show that the transcriptional repressor Blimp1is expressed in the intestine of mice at birth, and that expression is lost at the transition to the weaning stage.
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Cites
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Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
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Bile acids drive the newborn’s gut microbiota maturation
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Metadata
- Authors
- Muncan, V., Heijmans, J., Krasinski, S. D., Büller, N. V., Wildenberg, M. E., Meisner, S., Radonjic, M., Stapleton, K. A., Lamers, W. H., Biemond, I., van den Bergh Weerman, M. A., O'Carroll, D., Hardwick, J. C., Hommes, D. W., & van den Brink, G. R.
- Venue
- Nature Communications
- Published
- 2011-08-30
- Volume
- 2
- Issue
- 1
- Pages
- 452-452
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2160624223
- Cited by
- 165
- References
- 1
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Blimp1 regulates the transition of neonatal to adult intestinal epithelium. https://app.cochat.ai/papers/10.1038/ncomms1463
- The paper
- Muncan, V., Heijmans, J., Krasinski, S. D., Büller, N. V., Wildenberg, M. E., Meisner, S., Radonjic, M., Stapleton, K. A., Lamers, W. H., Biemond, I., van den Bergh Weerman, M. A., O'Carroll, D., Hardwick, J. C., Hommes, D. W., & van den Brink, G. R. (2011). Blimp1 regulates the transition of neonatal to adult intestinal epithelium. Nature Communications. https://doi.org/10.1038/ncomms1463
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
