Bile acids drive the newborn’s gut microbiota maturation
Open accessAbstract
Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6-10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n = 7-14 per group) accelerated postnatal microbiota maturation.
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Neonatal cholestasis is associated with dysbiosis in infants.
“Postnatal maturation of the GM in newborn mice was shown to be dependent on BAs and neonatal cholestasis is associated with dysbiosis in infants (326, 327).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [326]
Postnatal maturation of the gut microbiota in newborn mice is dependent on bile acids.
“Postnatal maturation of the GM in newborn mice was shown to be dependent on BAs and neonatal cholestasis is associated with dysbiosis in infants (326, 327).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [326]
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- Authors
- van Best, N., Rolle-Kampczyk, U., Schaap, F. G., Basic, M., Olde Damink, S. W. M., Bleich, A., Savelkoul, P. H. M., von Bergen, M., Penders, J., & Hornef, M. W.
- Affiliations
- Helmholtz Centre for Environmental Research (DE)
- Maastricht University (NL)
- Medizinische Hochschule Hannover (DE)
- Universitätsklinikum Aachen (DE)
- Corresponding author
- Penders, J.
- Hornef, M. W.
- ORCID
- Venue
- Nature Communications
- Published
- 2020-07-23
- Volume
- 11
- Issue
- 1
- Pages
- 3692-3692
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7378201
- OpenAlex
- W3044002524
- Cited by
- 226
- References
- 70
- Citations by year
- 2026: 27 · 2025: 38 · 2024: 54 · 2023: 32 · 2022: 43 · 2021: 26 · 2020: 6
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen)
- Funders
- Deutsche Forschungsgemeinschaft (HO2236/9-2, SFB1371, SFB 1382, SPP-1656, BL953/5-2, CRC1371, CRC 1382, /14-1, 403224013, 395357507)
- Universiteit Maastricht
- RWTH Aachen University
- NUTRIM School of Nutrition and Translational Research in Metabolism
- National Institute of Diabetes and Digestive and Kidney Diseases (U2CDK119886)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- bile acids, gut microbiota maturation, neonatal gut colonization, taurocholate, hepatic metabolism, liver function, postnatal development, host-microbe interactions, neonatal mice
- MeSH terms
- Gastrointestinal Microbiome, Administration, Oral, Animals, Animals, Newborn, Bile Acids and Salts, Intestinal Absorption, Kinetics, Lactobacillus, Liver, Mice, Inbred C57BL, Phylogeny, Principal Component Analysis, Metabolomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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