The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke
Open accessAbstract
Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke. The risk factors associated with both ischemic and haemorrhagic stroke are not fully understood. Here a certain strain of the bacteria,Streptococcus mutans, which expresses a collagen-binding protein, is shown to be associated with haemorrhagic stroke in both animal models and human patients.
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“CAN is a virulence factor in several animal models of infectious diseases. It also functions as an adhesin [68,69].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [69]
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Cites
Mortality by cause for eight regions of the world: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07493-4 · Cited by 4,043 · cited 1×
“jpg"/> Stroke causes 9% of all deaths worldwide and is the second most common cause of death after ischemic heart diseas”
BackgroundSurgical management of infective endocarditis associated with cerebral complications
Eishi, K., Kawazoe, K., Kuriyama, Y., Kitoh, Y., Kawashima, Y., & Omae, T. (1995) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70038-2 · Cited by 299
Cited by
Mobile Microbiome: Oral Bacteria in Extra-oral Infections and Inflammation
Han, Y. W., & Wang, X. (2013) · Journal of Dental Research · doi:10.1177/0022034513487559 · Cited by 486
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338
Role of Streptococcus mutans surface proteins for biofilm formation
Matsumoto-Nakano, M. (2018) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2017.08.002 · Cited by 282
Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology
Reyes, L., Herrera, D., Kozarov, E., Roldán, S., & Progulske‐Fox, A. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12079 · Cited by 237
Metadata
- Authors
- Nakano, K., Hokamura, K., Taniguchi, N., Wada, K., Kudo, C., Nomura, R., Kojima, A., Naka, S., Muranaka, Y., Thura, M., Nakajima, A., Masuda, K., Nakagawa, I., Speziale, P., Shimada, N., Amano, A., Kamisaki, Y., Tanaka, T., Umemura, K., & Ooshima, T.
- Venue
- Nature Communications
- Published
- 2011-09-27
- Volume
- 2
- Issue
- 1
- Pages
- 485-485
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2115342230
- Cited by
- 188
- References
- 2
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nakano, K., Hokamura, K., Taniguchi, N., Wada, K., Kudo, C., Nomura, R., Kojima, A., Naka, S., Muranaka, Y., Thura, M., Nakajima, A., Masuda, K., Nakagawa, I., Speziale, P., Shimada, N., Amano, A., Kamisaki, Y., Tanaka, T., Umemura, K., & Ooshima, T. (2011). The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nature Communications. https://doi.org/10.1038/ncomms1491
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
