BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

Cited by (369)

Items 301–369 of 369

  1. Analyzing and interpreting DNA double-strand break sequencing data
    Abhishek Mitra, Norbert Dojer, Bernard Fongang, Jules Nde, Yingjie Zhu, Maga Rowicka · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  2. DSB profiles in human spermatozoa highlight the role of TMEJ in the male germline
    Maurice Scheuren, Jonas Möhner, Max Müller, Hans Zischler · 2024 · Frontiers in Genetics
  3. Genome editing technologies and prospects for their use in biomedicine
    Maxim N. Karagyaur, Alexandra L. Primak, Джауари Сталик Станиславович, Бозов Кирилл Дмитриевич, Julia Makus · 2024 · Регенерация органов и тканей.
  4. Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor
    Ying Zhao, Tetsuro Hisayoshi, Doudou Zhang, Saaya Suzuki, Takashi Watanabe, Atsuo Kobayashi, Qianqian Guo, Yukihide Momozawa, Takashi Shimokawa, Shunsuke Kato et al. · 2025 · Cancer Science
  5. Breaking the script: transcriptional addiction as a driver of genome instability in cancer
    Osama Hidmi, Pei‐Chi Wei, Rami I. Aqeilan · 2025 · Trends in Genetics
  6. GPSeq maps the radial organization of eukaryotic genomes along the nuclear periphery–center axis
    Wing Hin Yip, Kaja Harton, Ilaria Castiglioni, Britta A. M. Bouwman, Carlos Jiménez, Emily Georgiades, Luuk Harbers, Wenjing Kang, Erik Wernersson, Nicola Crosetto et al. · 2026 · Nature Protocols
  7. Using the DNA language model, GROVER, to parse effects of sequence, chromatin and regulatory features on genome stability
    Pierre M. Joubert, Anton Vlasov, Nikola Janakievski, Melissa Sanabria, Anna R. Poetsch · 2026 · Bioinformatics
  8. Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes
    Alexandra Madsen, Niklas Selfjord, Marta Martínez-Lage, Anna-Lena Loyd, Gavin Kurgan, Mikaela Stahlberg, Julia Lindgren, Julia Liz Touza, Leif Wigge, Mike A. Firth et al. · 2026 · Nature Communications
  9. Next Generation Sequence-based Technologies for Analyzing DNA Strand Breaks
    Yui Fujiwara, Sachihiro Matsunaga, Takuya Sakamoto · 2021 · CYTOLOGIA
  10. Let’s not take DNA breaks for granted. The importance of direct detection of DNA breaks for the successful development of DDR inhibitors
    Kamil J. Solarczyk, Magdalena Kordon-Kiszala · 2023 · Frontiers in Cell and Developmental Biology
  11. ChromInSight: Revealing DNA Double‐Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework
    Kang Xu, YU Zong-yuan, Canzhuang Sun, Conglin Gou, Jiangyue Zhu, Jun Wang, Xiaochen Bo, Guoxian Yu, Hao Li, Hebing Chen · 2025 · Advanced Science
  12. Streptococcus uberis Cas9—A Compact Type II-A Nuclease Recognizing a Unique PAM and Functional in Human Cells
    A. Vasileva, Marina Abramova, P. Selkova, A. Arseniev, O. Musharova, Polina Malysheva, A. Demkina, M. Khodorkovskii, K. Severinov · 2025 · The CRISPR Journal
  13. CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine
    Sylvain Geny, Elaheh Sadat Hosseini, Jean‐Paul Concordet, Carine Giovannangeli · 2019 · Royal Society of Chemistry eBooks
  14. Analyzing Homologous Recombination at a Genome-Wide Level
    Coline Arnould, Vincent Rocher, Gaëlle Legube · 2020 · Methods in molecular biology
  15. Chimeric crRNAs Retaining Activity of Cas12a with Potential to Improve Specificity
    Jihyun Park, Jaewoo Choi, Men Thi Hoai Duong, Hee‐Chul Ahn, Seung Woo Hong, Gil Tae Hwang, Jinsu An, Hak Suk Chung, Dae‐Ro Ahn · 2020 · Bulletin of the Korean Chemical Society
  16. Assessing for off-target mutagenesis
    Kiran Musunuru · 2021 · Elsevier eBooks
  17. ERCC1-XPF Interacts with Topoisomerase IIβ to Facilitate the Repair of Activity-induced DNA Breaks
    Georgia Chatzinikolaou, Kalliopi Stratigi, Kyriacos Agathangelou, Maria Tsekrekou, Evi Goulielmaki, Ourania Chatzidoukaki, Katerina Gkirtzimanaki, Tamara Aid‐Pavlidis, Michalis Aivaliotis, Pavlos Pavlidis et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  18. From DNA Topology to Pubertal Onset: Using Integrative Genomic Approaches to Study Transcriptional Regulation
    Huayun Hou · 2019 · TSpace (University of Toronto)
  19. Engineered PAM-flexible FnCas9 variants for robust and specific genome editing and diagnostics
    Sundaram Acharya, Asgar Hussain Ansari, Seiichi Hirano, Deepanjan Paul, Riya Rauthan, Manoj Kumar, Rhythm Phutela, Sajal Sarkar, Sneha Gulati, Sudipta Mahato et al. · 2021 · Research Square
  20. Massively parallel genomic perturbations with multi-target CRISPR reveal new insights on Cas9 activity and DNA damage responses at endogenous sites
    Roger S. Zou, Alberto Marín-González, Yang Liu, Hans B. Liu, Leo L. Shen, Rachel K. Dveirin, Jay X. J. Luo, Reza Kalhor, Taekjip Ha · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Optimization of NLS Composition Improves CRISPR-Cas12a Editing Rates in Human Primary Cells
    Kevin Luk, Pengpeng Liu, Jing Zeng, Yetao Wang, Stacy A. Maitland, Feston Idrizi, Karthikeyan Ponnienselvan, Lihua Julie Zhu, Jeremy Luban, Daniel E. Bauer et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Specificity of CRISPR‐Cas9 Gene Editing
    Niklas Selfjord, Alexandra Madsen, Pınar Akçakaya · 2022 · Wiley eBooks
  23. Target-matched increased fidelity SpCas9 variants can edit any target without genome-wide off-target effects
    Péter István Kulcsár, András Tálas, Zoltán Ligeti, Eszter Tóth, Zsófia Rakvács, Vanessza Laura Végi, Sarah Laura Krausz, Krisztina Huszár, Ervin Welker · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Detection and Quantification of Genome Editing Events in Preclinical and Clinical Studies
    Marina Falaleeva, Shengdar Q. Tsai, Kathleen E. Meyer, Yanmei Lu · 2024 · Wiley eBooks
  25. Joint single-cell capture of Cas9 edits and transcriptomes reveals on- and off-target effects on gene expression
    Michael H. Lorenzini, Brad Balderson, Shanna N. Lavalle, Karthyayani Sajeev, Aaron J. Ho, Madelyn Light, Olalekan H. Usman, Gavin Kurgan, Graham McVicker · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  26. qDSB-Seq: quantitative DNA double-strand break sequencing
    Yingjie Zhu, Anna Biernacka, Benjamin Pardo, Norbert Dojer, Romain Forey, Magdalena Skrzypczak, Bernard Fongang, Jules Nde, Raziyeh Yousefi, Philippe Pasero et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Generating Isogenic Models of Li-Fraumeni Syndrome and Restoring p53 using CRISPR
    James Tran · 2020 · TSpace (University of Toronto)
  28. 農用トラクタの自動作業機能に関する研究 : IV. 油圧リンクによる播種深さ制御システムの開発
    實 小松, 輝明 佐藤 · 1995 · Institutional Repositories DataBase (IRDB)
  29. Replication origins drive genetic and phenotypic variation in humans
    Pierre Murat, Guillaume Guilbaud, Julian E. Sale · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Faculty Opinions recommendation of GPSeq reveals the radial organization of chromatin in the cell nucleus.
    Dana Branzei · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  31. Crispr-Embedding: CRISPR/Cas9 Off-Target Activity Prediction Using DNA k-Mer Embedding
    Swakkhar Shatabda, Anika Tahsin, Zarin Tasnim, Muneera Chowdhury, Kangkhita Hassin, Galib Hossain Meraz, Kazi Farzana Aziz · 2022 · SSRN Electronic Journal
  32. Molecular Mechanisms of Type II CRISPR ‐ Cas Systems
    Tautvydas Karvelis, Virginijus Šikšnys · 2022 · Wiley eBooks
  33. Nascent DNA sequencing and its diverse applications in genome integrity research
    Jacob Paiano, André Nussenzweig · 2023 · Methods in cell biology
  34. Data from AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
    Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, Benny Zhitomirsky, Yaara Oren, Sara K. Oster, Moshit Lindzen, Saptaparna Mukherjee, Rainer D. Will, Soma Ghosh et al. · 2023
  35. Data from AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
    Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, Benny Zhitomirsky, Yaara Oren, Sara K. Oster, Moshit Lindzen, Saptaparna Mukherjee, Rainer D. Will, Soma Ghosh et al. · 2023
  36. Sensitivity of DNA double-strand break loci is coupled with spatial interaction density of chromatin
    Hebing Chen, Kang Xu, Bijia Chen, Qiu Xie, Yu Sun, Xiang Xu, Junting Wang, Yaru Li, Pengzhen Hu, Shutong Yue et al. · 2023 · Research Square
  37. Bioinformatics tools and databases in genome editing for plants
    Aiman Arif, Rana Ali Haider, Ahmad Munir, Muhammad Zubair Ghouri, Sultan Habibullah Khan, Kamel Ahmed Abd-Elsalam, Aftab Ahmad · 2024 · Elsevier eBooks
  38. Additional file 2 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Yu Sun, Xiang Xu, Lin, Lin, Xu, Kang, Yang Zheng, Ren, Chao, Huan Tao, Xu Wang, Huan Zhao, Wei-Wei Tu et al. · 2023 · Figshare
  39. Resveratrol targets G-quadruplexes to exert its pharmacological effects
    Ana Soriano‐Lerma, Victoria Sánchez-Martín, Javier Murciano‐Calles, Matilde Ortiz-González, Maria J. Tello-Lopez, Virginia Pérez‐Carrasco, Ángel Linde-Rodríguez, Inmaculada Ramírez-Macías, Irene Gómez‐Pinto, Inmaculada López‐Aliaga et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  40. DNA Damage, Repair, and Advanced DNA Damage Detection Technologies
    Arlet Hernandez, Kaveri Goel, Saddam Hussain, Natalie R. Gassman · 2024 · Elsevier eBooks
  41. Precise Mapping of Physiological DSBs Using In-Suspension Break Labeling In Situ and Sequencing (sBLISS)
    Osama Hidmi, Sara K. Oster, Diala Shatleh, Jonathan Monin, Rami I. Aqeilan · 2025 · Methods in molecular biology
  42. Development of new increased fidelity SpCas9 variants
    Péter István Kulcsár · 2019
  43. Fast and accurate quantification of double-strand breaks in microsatellites by digital PCR
    Cécile Palao, Adèle Kovacs, Maria Teresa Teixeira, Guy‐Franck Richard · 2025 · Biology Methods and Protocols
  44. The multiscale distribution of radiation-induced DNA damage and its impact on local genome structure
    Heng Li, Tianchun Xue, Rachel Patton McCord · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Integrated In Vivo, In Vitro, and In Silico Evaluation of Spermacoce ocymoides Methanolic Extract for Antidiarrheal, Thrombolytic, and Antiarthritic Activities
    Bakul Akter, Kutub Uddin Ahamed, Md. Hossain Sohrab, Silvia Aishee, Bidhan Sarkar, Afra Anika, Mohammed Kamrul Hossain, Hanan M. Alharbi, Emad Rashad Sindi, Most. Nazmin Aktar · 2025 · Cell Biochemistry and Biophysics
  46. Sensitive, direct detection of non-coding off-target base editor unwinding and editing in primary cells
    Tong Wang, Selin Jessa, Georgi K. Marinov, Sandy L. Klemm, Anshul Bharat Kundaje, William James Greenleaf · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Genome Editing as Genetic Engineering Tool: Potential Applications in Production of Microbial Foods for Food Security
    Oluwafemi S. Obayori, Oluwaseun Oyetunji Olasunkanmi · 2025 · Springer eBooks
  48. A novel class of non-coding variants driving DNA double-strand breaks is associated with complex genetic diseases
    Sébastien Auber, Sarah Collins, Andrey Buyan, Ariuna Z Aiusheeva, Anne-Laure Finoux, Florian Saur, Sarah Cohen, Vincent Rocher, Coline Arnould, Marie Verbanck et al. · 2025 · medRxiv
  49. Additional file 4 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches
    Jeonghun Kwon, Kim, Minyoung, Hwang, Woochang, Anna Jo, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Gang Cui, Heon Seok Kim, Eom, Joon-Ho et al. · 2023 · Figshare
  50. Additional file 2 of ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing
    Camilo Ayala Breton, Peter Clark, Wang, Lili, Jenny A. Greig, James M. Wilson · 2020 · Figshare
  51. Additional file 3 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Sun, Yu, Xu, Xiang, Lin Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Huan Tao, Wang, Xu, Huan Zhao, Tu, Weiwei et al. · 2023 · Figshare
  52. Additional file 1 of ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing
    Camilo Ayala Breton, Clark, Peter M., Wang, Lili, Jenny A. Greig, James M. Wilson · 2020 · Figshare
  53. Additional file 3 of ITR-Seq, a next-generation sequencing assay, identifies genome-wide DNA editing sites in vivo following adeno-associated viral vector-mediated genome editing
    Camilo Ayala Breton, Peter Clark, Wang, Lili, Jenny A. Greig, James M. Wilson · 2020 · Figshare
  54. Additional file 2 of CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping
    Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael Cory Bassik, Chuan He et al. · 2023 · Figshare
  55. Additional file 1 of CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping
    Georgi K. Marinov, Samuel H. Kim, S. Tansu Bagdatli, Soon Il Higashino, Alexandro E. Trevino, Josh Tycko, Tong Wu, Lacramioara Bintu, Michael Cory Bassik, Chuan He et al. · 2023 · Figshare
  56. Additional file 1 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches
    Jeonghun Kwon, Kim, Minyoung, Hwang, Woochang, Anna Jo, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Gang Cui, Heon Seok Kim, Eom, Joon-Ho et al. · 2023 · Figshare
  57. Additional file 1 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Sun, Yu, Xu, Xiang, Lin Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Huan Tao, Wang, Xu, Huan Zhao, Tu, Weiwei et al. · 2023 · Figshare
  58. Additional file 6 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches
    Jeonghun Kwon, Kim, Minyoung, Hwang, Woochang, Anna Jo, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Gang Cui, Heon Seok Kim, Eom, Joon-Ho et al. · 2023 · Figshare
  59. Additional file 3 of Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches
    Jeonghun Kwon, Kim, Minyoung, Woo Chang Hwang, Anna Jo, Hwang, Gue-Ho, Jung, Minhee, Kim, Un Gi, Gang Cui, Heon Seok Kim, Eom, Joon-Ho et al. · 2023 · Figshare
  60. Additional file 4 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Sun, Yu, Xu, Xiang, Lin, Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Huan Tao, Wang, Xu, Huan Zhao, Tu, Weiwei et al. · 2023 · Figshare
  61. Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays
    Jingzhi Luo, Fanyu Zhao, Shuyan Lin, Yang Liu · 2026 · Medical Review
  62. 3-D Genome organization of DNA damage repair
    Ujjwal Kumar Banerjee · 2017 · theses.fr (ABES)
  63. CRISPR-Cas-Based Editing Technologies in Preclinical Models for Disease Correction
    Prakriti Karki, Sudarshan GC · 2026 · Genetics.
  64. Landscape of plastid DNA breaks in Arabidopsis during development and environmental stimulus
    Wenjie Wang, Chengxia Zheng, Kuan Li, Qianwen Sun · 2026 · The Plant Cell
  65. Off-target effects in genome editing for aquaculture species: Detection strategies, risk mitigation and regulatory perspectives
    Malik Wasim Mushtaq, Raja Aadil Hussain Bhat, Mohd Ashraf Rather, Irfan Ahmad Khan, Irfan Ahmad Bhat · 2026 · Ecological Genetics and Genomics
  66. Navigating off-target effects in CRISPR-based genome editing for safer gene therapies
    Anuradha Bhardwaj · 2026 · Discover Genetics and Evolution
  67. CRISPR-Based Genome Editing and Delivery Systems: Advances, Challenges and Future Directions
    Anroop Kaur, Ritika Chanan, Mehga Sharma, Shailja Sharma, Devender Sharma · 2026 · IntechOpen eBooks
  68. Haplotype-resolved genome of a dry-preservable cell line reveals chromosome evolution and DNA damage
    Yuki Yoshida, Takahiro Kikawada · 2026 · Life Science Alliance
  69. Dissecting the Radioresponse Heterogeneity of Lung Adenocarcinoma Cells From the Perspective of Transcriptional and Regulatory Landscape
    Huan Tao, Yaru Li, Leixin Ge, Lu Chen, Yang Zheng, Feiyue Ma, 葛常辉, 付汉江, Yu Sun, Longteng Wang et al. · 2026 · MedComm