Gao, Linyi

Rationally engineered Cas9 nucleases with improved specificity

Slaymaker, I. M., Gao, L., Zetsche, B., Scott, D. A., Yan, W. X., & Zhang, F. (2016) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,414

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nishimasu, H., Shi, X., Ishiguro, S., Gao, L., Hirano, S., Okazaki, S., Noda, T., Abudayyeh, O. O., Gootenberg, J. S., Mori, H., et al. (2018) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,100

Engineered Cpf1 variants with altered PAM specificities

Gao, L., Cox, D. B. T., Yan, W. X., Manteiga, J. C., Schneider, M. W., Yamano, T., Nishimasu, H., Nureki, O., Crosetto, N., & Zhang, F. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 460

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

Yan, W. X., Mirzazadeh, R., Garnerone, S., Scott, D., Schneider, M. W., Kallas, T., Custodio, J., Wernersson, E., Li, Y., Gao, L., et al. (2017) · Nature Communications

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 369

Highly Parallel Profiling of Cas9 Variant Specificity

Schmid-Burgk, J. L., Gao, L., Li, D., Gardner, Z., Strecker, J., Lash, B., & Zhang, F. (2020) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 197

Structural basis for the altered PAM recognition by engineered CRISPR-Cpf1

Nishimasu, H., Yamano, T., Gao, L., Zhang, F., Ishitani, R., & Nureki, O. (2017) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 102