The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
Open accessAbstract
miR-137 is a brain-enriched microRNA. Its role in neural development remains unknown. Here we show that miR-137 plays an essential role in controlling embryonic neural stem cell fate determination. miR-137 negatively regulates cell proliferation and accelerates neural differentiation of embryonic neural stem cells. In addition, we show that histone demethylase LSD1, a transcriptional co-repressor of nuclear receptor TLX, is a downstream target of miR-137. In utero electroporation of miR-137 in embryonic mouse brains led to premature differentiation and outward migration of the transfected cells. Introducing a LSD1 expression vector lacking the miR-137 recognition site rescued miR-137-induced precocious differentiation. Furthermore, we demonstrate that TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-137 by recruiting LSD1 to the genomic regions of miR-137. Thus, miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development.
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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Self-citationHistone demethylation by a family of JmjC domain-containing proteins
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Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
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Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation
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A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
Laurent, B., Ruitu, L., Murn, J., Hempel, K., Ferrao, R., Xiang, Y., Liu, S., Garcia, B. A., Wu, H., Wu, F., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.010 · Cited by 273
Self-citationMicroRNAs in neural development: from master regulators to fine-tuners
Rajman, M., & Schratt, G. (2017) · Development · doi:10.1242/dev.144337 · Cited by 269
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Metadata
- Authors
- Sun, G., Ye, P., Murai, K., Lang, M.-F., Li, S., Zhang, H., Li, W., Fu, C., Yin, J., Wang, A., Ma, X., & Shi, Y.
- Venue
- Nature Communications
- Published
- 2011-11-08
- Volume
- 2
- Issue
- 1
- Pages
- 529-529
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1965709906
- Cited by
- 303
- References
- 34
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, G., Ye, P., Murai, K., Lang, M.-F., Li, S., Zhang, H., Li, W., Fu, C., Yin, J., Wang, A., Ma, X., & Shi, Y. (2011). miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nature Communications. https://doi.org/10.1038/ncomms1532
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