The functions of animal microRNAs

Ambros, Victor

doi:10.1038/nature02871

Cited by 10,728MicroRNA in disease regulationDevelopmental Biology and Gene RegulationPlant Molecular Biology Research

The functions of animal microRNAs

Ambros, Victor·2004·Nature

DOI 10.1038/nature02871

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Abstract

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

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miRNA targeting of mRNAs inhibits their expression through mRNA destabilization, repression of translation, or a combination of both processes.
“miRNA targeting of mRNAs inhibits their expression through mRNA destabilization, repression of translation, or a combination of both processes (8–10).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [8]
miRNAs are critical regulators of gene expression acting predominantly at the posttranscriptional level.
“a class of noncoding RNAs, termed microRNAs (miRNAs), has emerged as critical regulators of gene expression acting predominantly at the posttranscriptional level (8–10).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [8]
miRNAs are 19-24 nucleotide noncoding RNAs that act as important regulators of posttranscriptional gene expression.
“MicroRNAs (miRNAs) are 19-to 24-nucleotide (nt) noncoding RNAs that act as important regulators of posttranscriptional gene expression (Ambros, 2004;Kim, 2005).”
From Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes (2013) · cites this paper as Ambros, 2004
MicroRNAs control essential cell processes in health and disease.
“In this role, they control essential cell processes in health and disease (Ambros 2004; Mendell and Olson 2012).”
From Toward the human cellular microRNAome (2017) · cites this paper as Ambros 2004

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works

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Retracted

Authors: Ambros, V.
Affiliations: Dartmouth College (US)
Corresponding author: Ambros, Victor
ORCID: Ambros, Victor
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-09
Volume: 431
Issue: 7006
Pages: 350-355
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02871
OpenAlex: W2014946489
Cited by: 10,728
References: 2
Citations by year: 2026: 123 · 2025: 229 · 2024: 318 · 2023: 353 · 2022: 486 · 2021: 646 · 2020: 725 · 2019: 738 · 2018: 769 · 2017: 785 · 2016: 704 · 2015: 787 · 2014: 701 · 2013: 655 · 2012: 610
FWCI: 13.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, gene expression regulation, post-transcriptional regulation, developmental timing, cell death, cell proliferation, hematopoiesis, phylogenetic conservation, animal development
MeSH terms: Animals, Gene Expression Regulation, Multigene Family, Substrate Specificity, Genomics, MicroRNAs

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The functions of animal microRNAs

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