The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Open accessAbstract
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8+T-cells and CD4+T-cells including T H 0, T H 1 and T H 17). The identified loci explain ∼28% of the genetic heritability and generate a discriminatory genetic risk score (AUC=0.76 in our sample) that is significantly correlated with age at onset (p=2 × 10−89). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis.
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An integrated map of genetic variation from 1,092 human genomes
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Self-citationGlobal Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence
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Genetic and epigenetic fine mapping of causal autoimmune disease variants
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Cited by
Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32549-6 · Cited by 2,383
Self-citationLarge-scale integration of the plasma proteome with genetics and disease
Ferkingstad, E., Sulem, P., Atlason, B. A., Sveinbjornsson, G., Magnusson, M. I., Styrmisdottir, E. L., Gunnarsdottir, K., Helgason, A., Oddsson, A., Halldorsson, B. V., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00978-w · Cited by 1,697
Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis
Ghoreschi, K., Balato, A., Enerbäck, C., & Sabat, R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00184-7 · Cited by 668
Self-citationAdvances in the pathogenesis of psoriasis: from keratinocyte perspective
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The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
Metadata
- Authors
- Tsoi, L. C., Stuart, P. E., Tian, C., Gudjonsson, J. E., Das, S., Zawistowski, M., Ellinghaus, E., Barker, J. N., Chandran, V., Dand, N., Duffin, K. C., Enerbäck, C., Esko, T., Franke, A., Gladman, D. D., Hoffmann, P., Kingo, K., Kõks, S., Krueger, G. G., Lim, H. W., Metspalu, A., Mrowietz, U., Mucha, S., Rahman, P., Reis, A., Tejasvi, T., Trembath, R., Voorhees, J. J., Weidinger, S., Weichenthal, M., Wen, X., Eriksson, N., Kang, H. M., Hinds, D. A., Nair, R. P., Abecasis, G. R., & Elder, J. T.
- Venue
- Nature Communications
- Published
- 2017-05-24
- Volume
- 8
- Issue
- 1
- Pages
- 15382-15382
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2618122943
- Cited by
- 384
- References
- 45
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tsoi, L. C., Stuart, P. E., Tian, C., Gudjonsson, J. E., Das, S., Zawistowski, M., Ellinghaus, E., Barker, J. N., Chandran, V., Dand, N., Duffin, K. C., Enerbäck, C., Esko, T., Franke, A., Gladman, D. D., Hoffmann, P., Kingo, K., Kõks, S., Krueger, G. G., . . . Elder, J. T. (2017). Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nature Communications. https://doi.org/10.1038/ncomms15382
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
