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Cited by 2,383

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Psoriasis

Griffiths, Christopher E M, Armstrong, April W, Gudjonsson, Johann E, Barker, Jonathan N W N·2021·The Lancet

Abstract

Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide, presenting at any age, and leading to a substantial burden for individuals and society. It is associated with several important medical conditions, including depression, psoriatic arthritis, and cardiometabolic syndrome. Its most common form, chronic plaque or psoriasis vulgaris, is a consequence of genetic susceptibility, particularly in the presence of the HLA-C*06:02 risk allele, and of environmental triggers such as streptococcal infection, stress, smoking, obesity, and alcohol consumption. There are several phenotypes and research has separated pustular from chronic plaque forms. Immunological and genetic studies have identified IL-17 and IL-23 as key drivers of psoriasis pathogenesis. Immune targeting of these cytokines and of TNFα by biological therapies has revolutionised the care of severe chronic plaque disease. Psoriasis cannot currently be cured, but management should aim to minimise physical and psychological harm by treating patients early in the disease process, identifying and preventing associated multimorbidity, instilling lifestyle modifications, and employing a personalised approach to treatment.

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Metadata

Authors
Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N.
Venue
The Lancet
Publisher
Elsevier BV
Published
2021-04
Volume
397
Issue
10281
Pages
1301-1315
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W4206739528
Cited by
2,383
References
124
FWCI
94.16
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Psoriasis. https://app.cochat.ai/papers/10.1016/s0140-6736(20)32549-6
The paper
Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N. (2021). Psoriasis. The Lancet. https://doi.org/10.1016/s0140-6736(20)32549-6

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.