Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Kim, Changyoun, Ho, Dong-Hwan, Suk, Ji-Eun, You, Sungyong, Michael, Sarah, Kang, Junghee, Joong Lee, Sung, Masliah, Eliezer +3 more·2013·Nature Communications

Cited by (863)

Items 501–600 of 863

  1. Interferon-γ Potentiates α-Synuclein-induced Neurotoxicity Linked to Toll-like Receptors 2 and 3 and Tumor Necrosis Factor-α in Murine Astrocytes
    Jintang Wang, Zheng Chen, Jeremy D Walston, Peisong Gao, Maolong Gao, Sean Xiao Leng · 2019 · Molecular Neurobiology
  2. Emerging contributions of formyl peptide receptors to neurodegenerative diseases
    Lukas Busch, Stefan Vieten, Susan Brödel, Kristina Endres, Bernd Bufe · 2021 · Biological Chemistry
  3. Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates
    Valdinocci, Dario, Grant, Gary D., Dickson, Tracey C., Pountney, Dean L. · 2018 · Molecular and Cellular Neuroscience
  4. Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
    Fiona C. Weiss, Laura P. Hughes, YuHong Fu, Cédric Bardy, Glenda Margaret Halliday, Nicolas L. Dzamko · 2024 · Translational Neurodegeneration
  5. Alpha-Synuclein drives NURR1 and NLRP3 Inflammasome dysregulation in Parkinson's disease: From pathogenesis to potential therapeutic strategies
    Ahmed M Abdelaziz · 2025 · International Immunopharmacology
  6. Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy
    Karen M. Delgado-Minjares, Daniel Martínez‐Fong, Irma Alicia Martínez-Dávila, Cecilia Bañuelos, María Eugenia Gutiérrez-Castillo, Víctor Manuel Blanco-Álvarez, María del Carmen Cárdenas‐Aguayo, José Luna‐Muñoz, Mar Pacheco‐Herrero, Luis Oskar Soto-Rojas · 2021 · International Journal of Molecular Sciences
  7. Recent Advances in Microglia Modelling to Address Translational Outcomes in Neurodegenerative Diseases
    Carla Cuní‐López, Romal Stewart, Hazel Quek, Anthony Robert White · 2022 · Cells
  8. Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson’s disease
    Yazead Buhidma, Carl Hobbs, Marzia Malcangio, Susan Duty · 2023 · npj Parkinson s Disease
  9. Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease
    Liang Kou, Xiaosa Chi, Yadi Sun, Sijia Yin, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong et al. · 2024 · Ageing Research Reviews
  10. Innate immune memory: The evolving role of macrophages in therapy
    Payal Damani‐Yokota, Kamal Mohan Khanna · 2025 · eLife
  11. γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde
    Yunxuan Li, Yixi Zhang, Xun Zeng · 2021 · Frontiers in Immunology
  12. What Is Our Understanding of the Influence of Gut Microbiota on the Pathophysiology of Parkinson’s Disease?
    Amaryllis E. Hill, Richard Wade‐Martins, Philip W. J. Burnet · 2021 · Frontiers in Neuroscience
  13. Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice
    Shinya Okuda, Norihito Uemura, Masanori Sawamura, Tomoyuki Taguchi, Masashi Ikuno, Maiko T. Uemura, Hodaka Yamakado, Ryōsuke Takahashi · 2021 · Neurotherapeutics
  14. A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
    Jessica Chedid, Adahir Labrador‐Garrido, Siying Zhong, Jianqun Gao, Ye Zhao, Gayathri Perera, Woojin Scott Kim, Glenda Margaret Halliday, Nicolas L. Dzamko · 2022 · Journal of Biological Chemistry
  15. α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications
    Amanda Li, Cyrus T. Rastegar, Xiaobo Mao · 2022 · Biomolecules
  16. Nuclear localization of alpha-synuclein affects the cognitive and motor behavior of mice by inducing DNA damage and abnormal cell cycle of hippocampal neurons
    Yue Pan, Qinglan Zong, Guoxiang Li, Zhengcun Wu, Tingfu Du, Zhangqiong Huang, Ying Zhang, Kaili Ma · 2022 · Frontiers in Molecular Neuroscience
  17. Targeting α-synuclein as a therapeutic strategy for Parkinson’s disease
    Nada Lawand, Nayef E. Saadé, Omar M. A. El‐Agnaf, Bared Safieh‐Garabedian · 2015 · Expert Opinion on Therapeutic Targets
  18. Aging and Neuroinflammatory Disorders: New Biomarkers and Therapeutic Targets
    Caterina Maria Gambino, Bruna Lo Sasso, Giulia Bivona, Luisa Agnello, Marcello Ciaccio · 2019 · Current Pharmaceutical Design
  19. TLR2 antagonism attenuates the hippocampal neuronal damage in a murine model of sleep apnea via inhibiting neuroinflammation and oxidative stress
    Yan Deng, Kui Liu, Yueying Pan, Jie Ren, Jin Shang, Lei Chen, Huiguo Liu · 2020 · Sleep And Breathing
  20. Resistance of naturally secreted α‐synuclein to proteolysis
    Methodios Ximerakis, Georgios Pampalakis, Theodoros I. Roumeliotis, Vasia Samantha Sykioti, Spiros D. Garbis, Leonidas Stefanis, Georgia Sotiropoulou, Kostas Vekrellis · 2014 · The FASEB Journal
  21. Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits
    Tzu-Feng Wang, Shih-Ying Wu, Bo‐Syong Pan, Sheng‐Feng Tsai, Yu‐Min Kuo · 2022 · Cells
  22. α‐Synuclein Oligomers: A Study in Diversity
    Femke van Diggelen, Armand W.J.W. Tepper, Mihaela M. Apetri, Daniel E. Otzen · 2016 · Israel Journal of Chemistry
  23. Down‐regulation of natural resistance‐associated macrophage protein‐1 (Nramp1) is associated with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)/1‐methyl‐4‐phenylpyridinium (MPP+)‐induced α‐synuclein accumulation and neurotoxicity
    Kuang‐Chong Wu, Horng‐Huei Liou, Chun-Yao Lee, Chun‐Jung Lin · 2018 · Neuropathology and Applied Neurobiology
  24. An interplay between immune response and neurodegenerative disease progression: An assessment using Drosophila as a model
    Jyoti Dhankhar, Namita Agrawal, Anju Shrivastava · 2020 · Journal of Neuroimmunology
  25. Transcriptome-wide analysis reveals core sets of transcriptional regulators of sensome and inflammation genes in retinal microglia
    Madhu Sudhana Saddala, Yang Xu, Shibo Tang, Huang Hu · 2021 · Genomics
  26. Exploring [11C]CPPC as a CSF1R-targeted PET imaging marker for early Parkinson’s disease severity
    Kelly A. Mills, Yong Du, Jennifer Marie Coughlin, Catherine A. Foss, Andrew G. Horti, Katelyn R. Jenkins, Yana Skorobogatova, Ergi Spiro, Chelsie Motley, Robert F. Dannals et al. · 2025 · Journal of Clinical Investigation
  27. Effects of exercise on neuroinflammation in age-related neurodegenerative disorders
    Yiping Su, Zhanguo Su · 2025 · European journal of medical research
  28. Nurr1 repression mediates cardinal features of Parkinson’s disease in α-synuclein transgenic mice
    Maria Argyrofthalmidou, Athanasios D. Spathis, Matina Maniati, Amalia Poula, Maria A. Katsianou, Evangelos Sotiriou, Maria Manousaki, Céline Perier, Ioanna Papapanagiotou, Zeta Papadopoulou‐Daifoti et al. · 2021 · Human Molecular Genetics
  29. Spreading of alpha-synuclein between different cell types
    Wolfgang Philipp Ruf, João L. Meirelles, Karin M. Danzer · 2022 · Behavioural Brain Research
  30. PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis
    Peng Wang, Darrell E. Anderson, Yihong Ye · 2023 · Cell & Bioscience
  31. Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson’s Disease
    Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek, Aaushi Pareek, Vivek Kumar Jain, Sonia Sonia, Zeba Farooqui, Ranjeet Kaur, Gurjit Singh · 2024 · Biomolecules
  32. Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
    Xiangbo Zhang, Haiyang Yu, Juan Feng · 2024 · Frontiers in Aging Neuroscience
  33. NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson’s disease
    Asma Khan, Robert Johnson, Carrie Wittmer, Michelle Maile, Keith J. Tatsukawa, Julian L. Wong, Martin B. Gill, Emily M. Stocking, Srinivasa Reddy Natala, Amy Paulino et al. · 2021 · Brain
  34. Potential Use of Nanomedicine for the Anti-inflammatory Treatment of Neurodegenerative Diseases
    María Dolores Cayero Otero, Ana M. Espinosa‐Oliva, Antonio J. Herrera, Irene García-Domínguez, Mercedes Fernández Arévalo, Lucía Martín‐Banderas, Rocío M. de Pablos · 2018 · Current Pharmaceutical Design
  35. Bridging pathway dysfunction and therapy: novel compounds for neuroprotection
    Shraddha Patel, Chandrabhan Prajapati, Sachchida Nand, Santosh Kumar Singh · 2026 · 3 Biotech
  36. Convergence of signalling pathways in innate immune responses and genetic forms of Parkinson’s disease
    Adamantios Mamais, Alice Kaganovich, Kirsten Harvey · 2022 · Neurobiology of Disease
  37. Repositioning doxycycline for treating synucleinopathies: Evidence from a pre-clinical mouse model
    Pietro La Vitola, Luisa Artioli, Milica Cerovic, Cristian Poletto, Letizia Dacomo, Susanna Leva, Claudia Balducci, Gianluigi Forloni · 2022 · Parkinsonism & Related Disorders
  38. Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson’s Disease: an Animal Model Study
    Wenwen Jiang, Yue Cheng, Ye Wang, Jing Wu, Zhe Rong, Li Sun, Yan Zhou, Kezhong Zhang · 2023 · Molecular Neurobiology
  39. Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction
    Yangxia Li, Qing Tong, Ye Wang, Yue Cheng, Yao Geng, Tian Tian, Yongsheng Yuan, Yi Fan, Ming Lu, Kezhong Zhang · 2024 · Cell Death Discovery
  40. α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease
    Emi Furusawa-Nishii, Bataa Solongo, Rai Kou, Soichiro Yoshikawa, A. Chiba, A. Okuzumi, Shin-ichi Ueno, Y. Hoshino, Yoko Imamichi-Tatano, Haruka Kimura et al. · 2025 · Journal of Neuroinflammation
  41. In vivo quantification of glial activation in minipigs overexpressing human α‐synuclein
    Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Natalie Landeck, Aage Kristian Olsen Alstrup, Steen Jakobsen, Kim Vang, Doris J. Doudet, David James Brooks, Deniz Kirik, Rainer Hinz et al. · 2018 · Synapse
  42. Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes
    Bruno Di Marco Vieira, Rowan A. W. Radford, Junna Hayashi, Emma D. Eaton, Ben Greenaway, Mark Jambas, Eugen Bogdan Petcu, Roger S. Chung, Dean L. Pountney · 2020 · Life
  43. Prion-like propagation of α-synuclein in the gut-brain axis
    Ying Chen, Qian-Hang Shao, Yu‐He Yuan, Nai‐Hong Chen · 2018 · Brain Research Bulletin
  44. Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes
    Chia, Sook-Yoong, Li, Mengwei, Li, Zhihong, Tu, Haitao, Lee, Jolene Wei Ling, Qiu, Lifeng, Ling, Jingjing, Reynolds, Richard, Albani, Salvatore, Tan, Eng-King et al. · 2025 · Genome Medicine
  45. α-Synuclein in traumatic and vascular diseases of the central nervous system
    Hong Zeng, Nan Liu, Xiao-Xie Liu, Yanyan Yang, Mouwang Zhou · 2020 · Aging
  46. The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex
    Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone et al. · 2022 · Cells
  47. Loss of cannabinoid receptor 2 promotes α-Synuclein-induced microglial synaptic pruning in nucleus accumbens by modulating the pCREB-c-Fos signaling pathway and complement system
    Linjuan Feng, Hsuan Lo, Hanlin You, Wei Wu, Xiaojuan Cheng, Jiawei Xin, Zu‐Cheng Ye, Xiaochun Chen, Xiaodong Pan · 2022 · Experimental Neurology
  48. Emerging trends in IRAK-4 kinase research
    Himanshu Kumar Yadav, Raj Kumar Shirumalla · 2023 · Molecular Biology Reports
  49. Inflammation and heterogeneity in synucleinopathies
    Antoine Freuchet, Anaëlle Pinçon, Alessandro Sette, Cecilia S. Lindestam Arlehamn · 2024 · Frontiers in Immunology
  50. TLR4 and TLR2 activation is differentially associated with age during Parkinson’s disease
    Hermínio Maurício da Rocha Sobrinho, Delson José da Silva, Larissa Fonseca Gomides, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Fátima Ribeiro‐Dias · 2017 · Immunological Investigations
  51. C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins
    Carl Alexander Sandhof, Simon Oliver Hoppe, Jessica Tittelmeier, Carmen I. Nussbaum-Krammer · 2020 · Biomolecules
  52. Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson’s disease
    Marie-Amandine Bonte, Fatima El Idrissi, Bernard Gressier, David Devos, Karim Bélarbi · 2021 · International Immunopharmacology
  53. A functional role for alpha-synuclein in neuroimmune responses
    Dustin L. Heiden, Brendan Monogue, Muhammad Ali, John David Beckham · 2023 · Journal of Neuroimmunology
  54. Olfactory Dysfunction and Its Association With Neuropathologic Proteins in Cerebrospinal Fluid From Patients With Parkinson Disease
    Peng Fei Guo, Ruidan Wang, Tenghong Lian, Du-yu Ding, Yanan Zhang, Weijiao Zhang, Dan-ning Li, Lixia Li, Jinghui Li, Huiying Guan et al. · 2020 · Frontiers in Aging Neuroscience
  55. Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic α-synuclein
    Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Infections in the Etiology of Parkinson’s Disease and Synucleinopathies: A Renewed Perspective, Mechanistic Insights, and Therapeutic Implications
    Gabriela Mercado, Christopher Käufer, Franziska Richter, Wouter Peelaerts · 2024 · Journal of Parkinson s Disease
  57. The Multifaceted Role of LRRK2 in Parkinson’s Disease
    Dong Hwan Ho, Sun Jung Han, Ilhong Son · 2025 · Brain Sciences
  58. Non-canonical autophagy in aging and age-related diseases
    Anita V. Kumar, Joslyn Mills · 2023 · Frontiers in Cell and Developmental Biology
  59. Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
    Noam Steinberg, Danny Galleguillos, Asifa K. Zaidi, Melanie Horkey, Simonetta Sipione · 2023 · Journal of Neuroinflammation
  60. A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates
    Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Hiroaki Sekiya, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Yuu‐ichi Kira, Dennis W. Dickson et al. · 2024 · Brain Behavior and Immunity
  61. Microglia contribute to polyG-dependent neurodegeneration in neuronal intranuclear inclusion disease
    Shaoping Zhong, Yangye Lian, Binbin Zhou, Ruiqing Ren, Lewei Duan, Yuyin Pan, Yuchen Gong, Xiaoling Wu, Dengfeng Cheng, Pu-Ming Zhang et al. · 2024 · Acta Neuropathologica
  62. The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective
    Haoran Xiang · 2025 · Frontiers in Neuroscience
  63. α -Synuclein Trafficking in Parkinson’s Disease: Insights From Fly and Mouse Models
    Jingjing Cheng, Qingqing Lu, Song Li, Margaret Su-chun Ho · 2018 · ASN NEURO
  64. Mesenchymal stem cells modulate misfolded α-synuclein in parkinsonian disorders: A multitarget disease-modifying strategy
    Jin Young Shin, Phil Hyu Lee · 2020 · Stem Cell Research
  65. Il-10 signaling reduces survival in mouse models of synucleinopathy
    Samuel G. Cockey, Karen N. McFarland, Emily J. Koller, Mieu Brooks, Elsa Gonzalez De La Cruz, Pedro E. Cruz, Carolina Ceballos‐Diaz, Awilda M. Rosario, Yona Levites, David Borchelt et al. · 2021 · npj Parkinson s Disease
  66. T-cell based immunotherapies for Parkinson’s disease
    Rodrigo Pacheco · 2021 · Exploration of Neuroprotective Therapy
  67. GBA1 and The Immune System: A Potential Role in Parkinson’s Disease?
    Zaid A.M. Al‐Azzawi, Saman Arfaie, Ziv Gan‐Or · 2022 · Journal of Parkinson s Disease
  68. Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells
    Frank M. Bearoff, Dhruva D. Dhavale, Paul T. Kotzbauer, Sandhya Kortagere · 2022 · Molecular Immunology
  69. The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson’s disease
    Yan Shen, Xingfang Guo, Chao Han, Fang Jung Wan, Kai Ma, Shiyi Guo, Luxi Wang, Yun Fei Xia, Ling Liu, Zhicheng Lin et al. · 2017 · Cellular and Molecular Life Sciences
  70. Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity
    Jarika Jahan Tumpa, Qurat Ul Ain Hayder, Nowshin Sharmily Maisa, Md. Nazmul Islam · 2025 · Frontiers in Molecular Neuroscience
  71. Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy
    Min-Sun Choi, Tae-Kyung Kim, Jin-Hyung Ahn, Jun Sung Lee, Byung Chul Jung, Sungwon An, Dongin Kim, Min Jae Lee, Inhee Mook‐Jung, Sang Hoon Lee et al. · 2022 · Experimental Neurobiology
  72. Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration
    Shih‐Heng Chen, Shuangyu Han, Chih-Fen Hu, Ran Zhou, Yun Gao, Dezhen Tu, Hui‐Ming Gao, Jing Feng, Yubao Wang, Ru‐Band Lu et al. · 2022 · Antioxidants
  73. Antibodies and α-synuclein: What to target against Parkinson's Disease?
    Daniel E. Otzen · 2023 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  74. TLR2 deficiency is beneficial at the late phase in MPTP-induced Parkinson’ disease mice
    Yongtao He, Jiayin Zhao, Hongtian Dong, Xiaoshuang Zhang, Yufei Duan, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Ping Huang · 2023 · Life Sciences
  75. What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson’s Disease?
    Jinsong Xue, Keju Tao, Weijia Wang, Xiaofei Wang · 2024 · International Journal of Molecular Sciences
  76. The investigation of peripheral inflammatory and oxidative stress biomarkers in dementia with Lewy Bodies, compared with Alzheimer’s Disease, and mild cognitive impairment
    Yueyi Yu, Huixin Shen, Qi Qin, Jing Wang, Yuting Nie, Lulu Wen, Yi Tang, Miao Qu · 2025 · Neuroscience
  77. Synucleinopathies Take Their Toll: Are TLRs a Way to Go?
    Gabriella Margherita Mazzotta, Nadia Ceccato, Carmela Conte · 2023 · Cells
  78. MultiTEP platform–based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency
    Hayk Davtyan, Karen Zagorski, Irina Petrushina, Konstantin Kazarian, Natalie R.S. Goldberg, Janet Petrosyan, Mathew M. Blurton-Jones, Eliezer Masliah, David H. Cribbs, Michael G. Agadjanyan et al. · 2017 · Neurobiology of Aging
  79. Microglia in the crosstalk between peripheral and central nervous systems in Parkinson’s disease
    Tianbai Li, Tao Qiu, Fei Jiang, Huaibin Cai, Weidong Le · 2025 · Translational Neurodegeneration
  80. Therapeutic Mechanisms of Exercise in Parkinson’s Disease
    Alice C. Wilson, Dean L. Pountney, Tien Kheng Khoo · 2025 · International Journal of Molecular Sciences
  81. Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases
    Yeseong Choi, Won‐Suk Chung · 2025 · Molecular Neurodegeneration
  82. Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes
    Ye-Seul Yoon, Woo Jung Ahn, Diadem Ricarte, Darlene Mae Ortiz, Chan Young Shin, Seung‐Jae Lee, He-Jin Lee · 2020 · Biomolecules & Therapeutics
  83. The role of the cellular prion protein in the uptake and toxic signaling of pathological neurodegenerative aggregates
    Carlo Scialò, Giuseppe Legname · 2020 · Progress in molecular biology and translational science
  84. NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation
    Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill · 2022 · International Journal of Inflammation
  85. Extracellular α-Synuclein Modulates Iron Metabolism Related Proteins via Endoplasmic Reticulum Stress in MES23.5 Dopaminergic Cells
    Xiaoqing Mi, Qijun Li, Xiaoming Wen, Junxia Xie, Youcui Wang, Ning Song · 2021 · Neurochemical Research
  86. Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
    Frank Y. Shan, Kar‐Ming Fung, Tarek Zieneldien, Janice Kim, Chuanhai Cao, Jason Haitao Huang · 2021 · Life
  87. Toll‐like receptor 10 controls TLR2‐induced cytokine production in monocytes from patients with Parkinson's disease
    Hermínio Maurício da Rocha Sobrinho, Rodrigo Saar Gomes, Delson José da Silva, Valéria Bernadete Leite Quixabeira, Leo A. B. Joosten, Cristina Ribeiro de Barros Cardoso, Fátima Ribeiro‐Dias · 2021 · Journal of Neuroscience Research
  88. RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia
    Jaegwon Chung, Janna E. Jernigan, Kelly B. Menees, Jae‐Kyung Lee · 2024 · Frontiers in Cellular Neuroscience
  89. Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases
    Eunmin Lee, Hyeonwoo Park, Sangjune Kim · 2024 · Molecules and Cells
  90. ⍺-Synuclein levels in Parkinson's disease – Cell types and forms that contribute to pathogenesis
    Giselle T. Sagredo, Onur Tanglay, Shrey Shahdadpuri, YuHong Fu, Glenda Margaret Halliday · 2024 · Experimental Neurology
  91. Alpha synuclein overexpression can drive microbiome dysbiosis in mice
    Sampson, Timothy R., Wallen, Zachary D, Won, Woong-Jai, Standaert, David G., Payami, Haydeh, Harms, Ashley S. · 2025 · Scientific Reports
  92. Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment
    Shurui Zhang, Jingwen Li, Xinyu Hu, Hanshu Liu, Qinwei Yu, Guiying Kuang, Long Liu, Danfang Yu, Zhicheng Lin, Nian Xiong · 2025 · Neural Regeneration Research
  93. Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists
    Srinivasa Reddy Natala, Agata Habas, Emily M. Stocking, Andrew J. W. Orry, Diana L. Price, Martin B. Gill, Douglas W. Bonhaus, Ruben A Abagyan, Wolfgang Wrasidlo · 2021 · Bioorganic & Medicinal Chemistry Letters
  94. Gut-oriented disease modifying therapy for Parkinson's disease
    Chin‐Hsien Lin, Hsin‐Chih Lai, Ming‐Shiang Wu · 2022 · Journal of the Formosan Medical Association
  95. Couldα-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?
    Maria Antònia Busquets, Alba Espargaró, Joan Estelrich, Raimon Sabaté · 2015 · BioMed Research International
  96. X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
    Christine A. Vaine, David S. Shin, Christina H. Liu, William T. J. Hendriks, Jyotsna Dhakal, Kyle Shin, Nutan Sharma, D. Cristopher Bragg · 2016 · Neurobiology of Disease
  97. NRF2 at the crossroads of Parkinson’s disease and aging: Mechanistic insights and translational perspectives
    Ángel J. García‐Yagüe, Noemí Esteras, Albena T. Dinkova‐Kostova, Rojo AI, Paul G. Shiels, András Dinnyés, Tamas V, Harry van Goor, Isabel Lastres‐Becker · 2026 · Free Radical Biology and Medicine
  98. Interaction between α-Synuclein and Bioactive Lipids: Neurodegeneration, Disease Biomarkers and Emerging Therapies
    Chiara Sanluca, P. Spagnolo, Romina Mancinelli, Maria Ilenia De Bartolo, Marina Fava, Mauro Maccarrone, Simone Carotti, Eugenio Gaudio, Alessandro Leuti, Giorgio Vivacqua · 2024 · Metabolites
  99. Imaging flow cytometry reveals LPS-induced changes to intracellular intensity and distribution of α-synuclein in a TLR4-dependent manner in STC-1 cells
    Anastazja M. Gorecki, Chidozie C. Anyaegbu, Melinda Fitzgerald, Kathryn A. Fuller, Ryan S. Anderton · 2024 · Methods
  100. Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms
    Dharmin Rokad, Dilshan S. Harischandra, Manikandan Samidurai, Yuan-Teng Chang, Jie Denny Luo, Vivek Lawana, Souvarish Sarkar, Bharathi N. Palanisamy, Sireesha Manne, Dong-Suk Kim et al. · 2024 · International Journal of Molecular Sciences