Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Kim, Changyoun, Ho, Dong-Hwan, Suk, Ji-Eun, You, Sungyong, Michael, Sarah, Kang, Junghee, Joong Lee, Sung, Masliah, Eliezer, Hwang, Daehee, Lee, He-Jin, Lee, Seung-Jae·2013·Nature Communications
Cited by (863)
Items 801–863 of 863
- Additional file 4 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny et al. · 2021 · Figshare
- Additional file 8 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Krüger, Christina, Paul Dembny et al. · 2021 · Figshare
- Additional file 1 of Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like diseaseMichiyo Iba, Somin Kwon, Changyoun Kim, Marcell P. Szabo, Liam Horan-Portelance, Maria D Lopez-Ocasio, Pradeep Kumar Dagur, Cassia Overk, Robert A. Rissman, Masliah, Eliezer · 2024 · Figshare
- Additional file 3 of Neuroinflammation and protein pathology in Parkinson’s disease dementiaAntonina Kouli, Marta Camacho, Allinson, Kieren, Caroline H. Williams‐Gray · 2020 · Figshare
- Additional file 1 of p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's diseaseChen, Jialong, Mao, Kanmin, Yu, Honglin, Wen, Yue, She, Hua, Zhang, He, Liu, Linhua, Mingque Li, Li, Wenjun, Zou, Fei · 2021 · Figshare
- Additional file 11 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny et al. · 2021 · Figshare
- Additional file 5 of p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's diseaseChen, Jialong, Mao, Kanmin, Yu, Honglin, Wen, Yue, She, Hua, Zhang, He, Liu, Linhua, Mingque Li, Li, Wenjun, Zou, Fei · 2021 · Figshare
- Additional file 1 of Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicityEmil Gregersen, Cristine Betzer, Kim, Woojin S., Gergő E. Kovács, Lasse Reimer, Glenda M. Halliday, Steffen Thiel, Jensen, Poul Henning · 2021 · Figshare
- Additional file 4 of Neuroinflammation and protein pathology in Parkinson’s disease dementiaAntonina Kouli, Marta Camacho, Allinson, Kieren, Caroline H. Williams‐Gray · 2020 · Figshare
- Additional file 3 of p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's diseaseChen, Jialong, Mao, Kanmin, Yu, Honglin, Wen, Yue, She, Hua, Zhang, He, Liu, Linhua, Mingque Li, Li, Wenjun, Zou, Fei · 2021 · Figshare
- Additional file 13 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny et al. · 2021 · Figshare
- Additional file 6 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny et al. · 2021 · Figshare
- Additional file 4 of p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's diseaseChen, Jialong, Mao, Kanmin, Yu, Honglin, Wen, Yue, She, Hua, Zhang, He, Liu, Linhua, Mingque Li, Li, Wenjun, Zou, Fei · 2021 · Figshare
- Additional file 1 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny et al. · 2021 · Figshare
- Additional file 10 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Krüger, Christina, Paul Dembny et al. · 2021 · Figshare
- Additional file 9 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegenerationWallach, Thomas, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui S. R. Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Krüger, Christina, Paul Dembny et al. · 2021 · Figshare
- Immunomodulatory effects of anesthetic drugs and their implications in neurodegenerative disease progressionMohammed Hadi Kadhim Al-Juhaishi, Nooralhuda Mohammed Hadi Al-Juhaishi, Ahmed Mohammed Hadi Al-Juhaishi · 2024 · Neurophysiology
- Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementiaJi Young Kim, Keunhyung Lee, Minseok Koo, Doeun Kim, Jin Kyung Hong, Jeong-Yun Choi, Han Seok Ko, Joo-Ho Shin, Joo Min Park, Jinhyoung Park et al. · 2026 · Translational Neurodegeneration
- Animal and Cell Models in Alzheimer’s and Parkinson’s Disease: Current Innovations ReviewedChristopher Rejitha, Lavanya Babu · 2026 · Current Aging Science
- A new therapeutic approach for Parkinson’s disease: dual targeting of α-Synuclein aggregation and microglial function by the novel immunomodulator 3-MonothiopomalidomideMaria Francesca Palmas, Khosro Aminzadeh, Matteo Runfola, Pathik Parekh, Clara Porcedda, David Tweedie, Luca Casula, Maria Cristina Cardia, Jacopo Marongiu, Michela Etzi et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Contrôle de l'activation microgliale par les lymphocytes T dans un modèle murin de neurodégénérescence induite par la 6-OHDAJosselin Uhlrich · 2014 · theses.fr (ABES)
- Diversité Génétique des Molécules de Réponse Immunitaire Innée dans les Troubles BipolairesJosé Oliveira · 2015 · theses.fr (ABES)
- Understanding the role of perivascular macrophages in Parkinson's disease pathophysiologyJaime R. Fuentealba · 2017 · theses.fr (ABES)
- Etude de la coopération de l'alpha-synucléine et de LRRK2 dans les dysfonctions mitochondriales dans la Maladie de ParkinsonCamille Gardier · 2019 · theses.fr (ABES)
- Evaluation of an In Situ Polymerizing Hydrogel Scaffold as a Brain Delivery System for Parkinson’s Disease therapeuticsFrancesco Gubinelli · 2019 · theses.fr (ABES)
- Multifactorial and translational approaches for modeling synucleinopathies : mechanistic and therapeutic implicationsMarie-Laure Arotçarena · 2019 · theses.fr (ABES)
- Étude de la composante neuroinflammatoire dans les DFT/SLAJulie Smeyers · 2020 · theses.fr (ABES)
- Étude moléculaire de l'inflammation chronique dans la maladie de ParkinsonAnne‐Claire Compagnion · 2019 · theses.fr (ABES)
- Study of the interactions between the nervous system and the gut in Parkinson’s disease using DrosophilaXiaojing Yue · 2022 · theses.fr (ABES)
- Towards the identification of targets and markers of Parkinson’s disease-associated neuroinflammationCansu Yildirim-Balatan · 2021 · theses.fr (ABES)
- Characterization and quantification of proteins involved in neurodegenerative diseases by mass spectrometryKim Thanh Van · 2025 · theses.fr (ABES)
- Angelic Acid Disassembles Fibrillar α-Synuclein Aggregates through β-Sheet Interface DisruptionHyo Gi Jung, Junho Bang, Juhyun Kim, Yong Wook Kim, Wonbin Moon, Hyunji Kim, Jisung Yoon, Kyo Seon Hwang, Jeong Hoon Lee, S Lee et al. · 2026 · ACS Chemical Neuroscience
- Lysophospholipids in Synucleinopathies: A Conceptual Framework Linking Proteostasis and Neuroinflammatory SignalingTamotsu Tsukahara, Hisao Haniu, Yoshikazu Matsuda · 2026 · Brain Sciences
- Beyond the brain: a multisystem review of pathogenesis, comorbidity, and therapeutic progress in sporadic Parkinson’s diseaseYang Li, Lijun Guo, Xiya Yu, Changgeng Peng · 2026 · Ageing and Neurodegenerative Diseases
- Formation and toxicity of protein misfolded oligomers: Mechanistic insights and therapeutic opportunities in protein aggregation diseasesLorenzo Neri, Carol A. Anderson, Lucas B. Fallot, Benedetta Mannini, Ryan Limbocker · 2026 · Elsevier eBooks
- Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson’s diseaseSkye Hsin‐Hsien Yeh, Tsung-Hsun Yu, Chia-Ju Liu, Sung‐Pin Fan, Pin‐Shiuan Chen, Cheng‐Hsuan Li, Mei‐Fang Cheng, Chin‐Hsien Lin · 2026 · European Journal of Nuclear Medicine and Molecular Imaging
- Propagation of α-synuclein pathology: models, mechanisms and future goalsAryeh Zolin, Sarah A. Weber, Yan Xin Xie, Jacqueline Burré · 2026 · Molecular Neurodegeneration Advances
- Alpha-synuclein at the crossroads of host–virus interactions: immunological roles beyond the nervous systemValentina Artusa, Fiona Limanaqi, Elena Santacroce, Mario Clerici, Andrea Cossarizza, Mara Biasin, Lara Gibellini, Daria Trabattoni · 2026 · Journal of Virology
- Blood-brain barrier model architecture shapes peripheral immune cell trafficking in Parkinson’s diseaseOceane Martinez, Lucile Gentile, Floriane Bretheau, Allison Yearwood, O.J. Arevalo, Flávia Natale Borba, Martine Boutin, Françoise Morin, Myriam Vaillancourt, Sylvie Breton et al. · 2026 · Acta Neuropathologica Communications
- From Air to Brain: Environmental Nanoparticles as Modifiable Risk Factors for Neurodevelopmental, Neurodegenerative, and Mental DisordersCristina Hermosillo‐Abundis, Óscar Arias-Carrión, Carlos César Contreras‐Ibáñez, M.A. Mendéz-Rojas · 2026 · ACS Omega
- Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality controlElisabeth Fritsch, Kamelija Horvatović, Paula Santos Otte, Tomáš Koudelka, Jana Rossius, Caroline Braeuning, Laura Breimann, Ilaria Piazza, Melissa Birol · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Unconventional Protein Secretion in the Central Nervous System: Mechanisms and Roles in Physiology and DiseaseSteven A. Krauklis, Sevnur Kömürlü Keceli, Edward M. Campbell, Prabhodh S. Abbineni · 2026 · Journal of Neurochemistry
- Brain macrophages in neurodegenerationRachel J. Johnston, Nicole A. Pagán Torres, Yangchen Li, Claudia Z. Han · 2026 · Advances in immunology
- Mechanistic insights into the inhibition of α-synuclein aggregation by sugar-based nanoparticlesDanish Alam, Tanzeel Khan, Iqra Sadiq, Priyanka Mudad, Malik Aquib Javed, Tokeer Ahmad, Asimul Islam, Meryam Sardar · 2026 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Parkinson’s Disease, Microglia, and Extracellular Matrix RemodelingNorma Serrano‐García, Alexis Ponce-Juárez, Maximiliano Ganado, Javier Pérez-Villavicencio, Moisés Rubio‐Osornio · 2026 · Neuroglia
- Glia-Based Early Diagnosis of Prodromal Parkinson’s Disease: From REM Sleep Behavior Disorder to Brainstem Circuit DysfunctionKyungchul Noh, Sang Myun Park · 2026 · KOBRA Reports
- Tuberculosis and Parkinson's disease: is there really a link?Thomas Schiestel · 2026 · Medical Hypotheses
- Plasma α-synuclein and QSM-derived susceptibility in Parkinson’s disease: associations with clinical featuresXingjun Li, Tianfei Luo, Jing Bai · 2026 · Frontiers in Aging Neuroscience
- Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker StratificationLivia Livinț Popa, Andreea Nicolaie, Alexandra Maștaleru, Ștefan Socolov, Mihaela Mitrea, Gabriela Popescu, Thomas Gabriel Schreiner, Roxana Ana Covali, Laura-Elena Cucu, Lucia Corina Dima-Cozma et al. · 2026 · Medical Sciences
- Plastamination in Human Brain: The Possible Role of Microplastics in Neuroinflammation and Parkinson’s DiseaseEzia Guatteo, Maria Zelinda Romano, Nicola Berretta, Mario Ruggiero, Antonietta Santoro, Filomena Mazzeo, Rosaria Meccariello · 2026 · Microplastics
- Engineered α-Synuclein-specific nanobody CAR iTregs restrain neuroinflammation and proteinopathy in Parkinson’s disease miceAlice Calderoni, Melania Nannoni, Giorgia Ruffini, Matteo Doglio, Clara Bercher-Brayer, Serena Gea Giannelli, Ronald Melki, Monica Casucci, Chiara Bonini, Sharon Muggeo et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Retromer-targeted therapy for neurodegenerative diseasesMichele Persico, Sophronea Tuithung, Alejandra Lorenzo, Darynaisha Crawford, Simona Eleuteri, David K. Simon · 2026 · Molecular Neurodegeneration
- Brain region-resolved pharmacodynamics of an antisense oligonucleotide targeting human SNCA 3′UTR in BAC-hSNCA ratsMarianna Naki, Fedon-Giasin Kattan, Marina Pantazopoulou, Sissy Skea, Dimitrios Zisis, Eleftherios Pilalis, Maria Fouka, Effrosyni Koronaiou, Christos Fotis, Olaf Rieß et al. · 2026 · Translational Neurodegeneration
- Mechanisms of Brain Aging and Their Links to Alzheimer’s and Parkinson’s Disease PathologyHaiyi Yi, Haimeng Qin, Jo Aan Goon, Suzana Makpol, Jen Kit Tan · 2026 · International Journal of Molecular Sciences
- α‐Synuclein Promotes Atherosclerosis by Impairing Macrophage Autophagic FluxMengting Qin, Xuying Xiang, Xiaoqing Guo, Shengnan Wang, 陈姣姣, Dailiang Jiang, Yuhang Feng, Jiangnan Yu, Ling Mao · 2026 · Aging Cell
- Cellular and systemic modifiers of alpha-synuclein proteostasisSuzanne Couzijn, Anna P. Ainslie, Alejandro Herrón-Bedoya, Ellen A. A. Nollen · 2026 · Philosophical Transactions of the Royal Society B Biological Sciences
- Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosisHung-Ju Chueh, Antigoni Katsikoudi, Ana Aragón-González, Chor Lai Lam, Liezel Tamon, Ashwin Jainarayanan, Devika Agarwal, Sally A. Cowley, David Sims, George K. Tofaris · 2026 · Science Translational Medicine
- The dual immunomodulatory roles and signaling mechanisms of toll-like receptor 2 in different diseasesChenyu Le, Xiulin Dong, Ying Bian, Yuting Liu, Xinyi Gu, Xiaofeng Zhang, Jianfeng Yang, Lingyun Li · 2026 · Biochemical Pharmacology
- CD38 inhibition increases neuronal survival and reduces α-synuclein in vitro, elevates brain NAD+, and reduces motor deficits in a Parkinson’s disease modelJenna R. M. Harvey, Thomas H. Wight, Maxine Roberts, Victoria J. Mulligan, Daniel F. Barker, Chloe Sherlock, Bernardino Ossola, Richard Hewer, Xiao Xu, Keith J. Page et al. · 2026 · Frontiers in Pharmacology
- Microbial metabolites as modulators of gut–brain communication in neurodegeneration: from intestinal sensing to disease initiation and progressionXi Liu, Sirui Wang, Wei Long, Xinyue Tan, Wanlin Li, LiChen Gao · 2026 · Frontiers in Aging Neuroscience
- BindingDB Entry 50013860: Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists.BindingDB · 2022 · UC San Diego
- Immunometabolic dysregulation of reactive microglia and astrocytes in neurodegenerative diseases: Mechanistic insights and therapeutic implicationsCheng Gao, Ran Shi, Xianliang Jiang, Hui Chai, Xiao He · 2026 · Journal of the Neurological Sciences
- Targeting α-Synuclein as a Parkinson’s Disease TherapeuticLuke Esposito · 2014 · Topics in medicinal chemistry