The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae
Open accessAbstract
To cause plant diseases, pathogenic micro-organisms secrete effector proteins into host tissue to suppress immunity and support pathogen growth. Bacterial pathogens have evolved several distinct secretion systems to target effector proteins, but whether fungi, which cause the major diseases of most crop species, also require different secretory mechanisms is not known. Here we report that the rice blast fungus Magnaporthe oryzae possesses two distinct secretion systems to target effectors during plant infection. Cytoplasmic effectors, which are delivered into host cells, preferentially accumulate in the biotrophic interfacial complex, a novel plant membrane-rich structure associated with invasive hyphae. We show that the biotrophic interfacial complex is associated with a novel form of secretion involving exocyst components and the Sso1 t-SNARE. By contrast, effectors that are secreted from invasive hyphae into the extracellular compartment follow the conventional secretory pathway. We conclude that the blast fungus has evolved distinct secretion systems to facilitate tissue invasion. Understanding how fungal pathogens deliver proteins to diverse plant compartments is critical for developing disease control. Giraldo et al. demonstrate that the blast fungus possesses distinct secretion systems for proteins targeted to compartments inside or outside living rice cells.
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Cited by
Fungal Effectors and Plant Susceptibility
Lo Presti, L., Lanver, D., Schweizer, G., Tanaka, S., Liang, L., Tollot, M., Zuccaro, A., Reissmann, S., & Kahmann, R. (2015) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043014-114623 · Cited by 1,249
Pathways of Unconventional Protein Secretion
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The plant immune system: From discovery to deployment
Jones, J. D. G., Staskawicz, B. J., & Dangl, J. L. (2024) · Cell · doi:10.1016/j.cell.2024.03.045 · Cited by 544
Filamentous plant pathogen effectors in action
Giraldo, M. C., & Valent, B. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3119 · Cited by 498
Self-citationLiu, T., Song, T., Zhang, X., Yuan, H., Su, L., Li, W., Xu, J., Liu, S., Chen, L., Chen, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5686 · Cited by 393
Metadata
- Authors
- Giraldo, M. C., Dagdas, Y. F., Gupta, Y. K., Mentlak, T. A., Yi, M., Martinez-Rocha, A. L., Saitoh, H., Terauchi, R., Talbot, N. J., & Valent, B.
- Venue
- Nature Communications
- Published
- 2013-06-18
- Volume
- 4
- Issue
- 1
- Pages
- 1996-1996
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1979796171
- Cited by
- 424
- References
- 51
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Giraldo, M. C., Dagdas, Y. F., Gupta, Y. K., Mentlak, T. A., Yi, M., Martinez-Rocha, A. L., Saitoh, H., Terauchi, R., Talbot, N. J., & Valent, B. (2013). Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae. Nature Communications. https://doi.org/10.1038/ncomms2996
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