The distinct morphogenic states of Candida albicans

Sudbery, Peter; Gow, Neil; Berman, Judith

doi:10.1016/j.tim.2004.05.008

Cited by 876Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

The distinct morphogenic states of Candida albicans

Sudbery, Peter, Gow, Neil, Berman, Judith·2004·Trends in Microbiology

DOI 10.1016/j.tim.2004.05.008

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Abstract

The human fungal pathogen, Candida albicans can grow in at least three different morphologies: yeast, pseudohyphae and hyphae. Further morphological forms exist during colony switching, for example, opaque phase cells are oblong, rather than the oval shape of yeast cells. Pseudohyphae and hyphae are both elongated and sometimes there has been little attempt to distinguish between them, as both are "filamentous forms" of the fungus. We review here the differences between them that suggest that they are distinct morphological states. We argue that studies on "filamentous forms" should always include a formal analysis to determine whether the cells are hyphae or pseudohyphae and we suggest some simple experimental criteria that can be applied to achieve this.

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The pathogenicity and immunogenicity of Candida species are closely linked to these morphological alterations.
“The pathogenicity and immunogenicity of Candida species are closely linked to these morphological alterations99.”
From Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR (2025) · cites this paper as [99]
C. albicans is a trimorphic fungus that can grow as unicellular budding yeast and in two filamentous, multicellular forms: hyphae and pseudohyphae.
“This trimorphic fungus can grow as unicellular budding yeast and in two filamentous, multicellular forms: hyphae and pseudohyphae.”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans (2012) · cites this paper as Sudbery et al., 2004
Pseudohyphae and hyphae are distinct morphologies: pseudohyphae resemble chains of elongated yeast cells, are wider than hyphae, and have clear constrictions at cellular junctions; hyphae are thinner, lack a constriction between mother and daughter cell, and have unconstricted septa.
“Pseudohyphae and hyphae are distinct morphologies. Pseudohyphae resemble chains of elongated yeast cells; they are wider than hyphae and have clear constrictions at cellular junctions. Hyphae are thinner, lack a constriction between the mother and daughter cell, and have unconstricted septa.”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans (2012) · cites this paper as Sudbery et al., 2004
One of the major features that distinguish true hyphae from yeast or pseudohyphae is their mode of cell cycle progression.
“One of the major features that distinguish true hyphae from yeast or pseudohyphae is their mode of cell cycle progression (Sudbery et al., 2004; Berman, 2006).”
From Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans (2012) · cites this paper as Sudbery et al., 2004

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Authors: Sudbery, P., Gow, N., & Berman, J.
Affiliations: University of Sheffield (GB)
University of Aberdeen (GB)
University of Minnesota (US)
Corresponding author: Sudbery, Peter
ORCID: Sudbery, Peter
Gow, Neil
Berman, Judith
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2004-07
Volume: 12
Issue: 7
Pages: 317-324
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2004.05.008
OpenAlex: W2002379595
Semantic Scholar: 2f3367b17a0ee5cde5e86f7c6c13f96eaa899924
Cited by: 876
References: 47
Citations by year: 2026: 21 · 2025: 25 · 2024: 37 · 2023: 40 · 2022: 49 · 2021: 43 · 2020: 53 · 2019: 53 · 2018: 36 · 2017: 46 · 2016: 36 · 2015: 50 · 2014: 56 · 2013: 43 · 2012: 40
FWCI: 2.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida albicans, morphogenesis, yeast, pseudohyphae, fungal hyphae, filamentous growth, fungal morphology
MeSH terms: Candida albicans, Cell Cycle, Fungal Proteins, Genes, Fungal, Morphogenesis, Yeasts, Gene Expression Regulation, Fungal, Hyphae

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The distinct morphogenic states of Candida albicans

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