Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Olenchock, Benjamin A., Mayers, Jared R., Wasylenko, Thomas M., Vokes, Natalie I., Guarente, Leonard +2 more·2013·Nature Communications
DOI 10.1038/ncomms3236

Cited by (364)

Items 301–364 of 364

  1. Guaiazulene derivative 1,2,3,4‐tetrahydroazuleno[1,2‐b] tropone reduces the production of ATP by inhibiting electron transfer complex II
    Chieko Kasami, Jun‐ichi Yamaguchi, Hideki Inoue · 2021 · FEBS Open Bio
  2. Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma
    Dashnamoorthy Ravi, Athena Kritharis, Andrew M. Evens · 2024 · Cancers
  3. ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC
    Nathan L. Tran, Jiewei Jiang, Min Ma, Gillian E. Gadbois, Kevin Christian Montecillo Gulay, Alyssa L. Verano, Haowen Zhou, Chun‐Teng Huang, David A. Scott, Anne G. Bang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Proton‐Nuclear Magnetic Resonance Metabolomics of Gingival Crevicular Fluid During Orthodontic Tooth Movement With Aligners
    Maria Chiara Domini, Tommaso Castroflorio, Andrea Deregibus, Serena Ravera, Giuseppe Migliaretti, Massimo Costalonga · 2025 · Orthodontics and Craniofacial Research
  5. Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis
    Liyan Liu, Yiqing Li, Dongwei Guo, Huiwen Ye, Haotian Qi, Bin Zou, Danying Zheng, Guangming Jin · 2022 · Current Eye Research
  6. Metabolic Remodeling in Bioenergetic Disorders and Cancer
    Émilie Obre, Rodrigue Rossignol · 2015 · Springer eBooks
  7. Reductive carboxylation of glutamine as a potential target in acute myeloid leukemia
    Alessia Roma, Lawrence D. Goodridge, Paul A. Spagnuolo · 2023 · Oncotarget
  8. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
    Megan M. Sperry, Bérénice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani T. Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski et al. · 2024 · eLife
  9. Phenotypic pharmacology of novel Complex I inhibitors eliciting tissue repair concurrent to control of inflammation
    Lisa Patel, Fatima Garcia-Raposo, Benjamin J. R. Moore, James Wood, Lily Morley, David Loczenski, Stephen A. Smith, Puneeta Nath, Nicholas D. Holliday, Sam Williams et al. · 2025 · Journal of Pharmacology and Experimental Therapeutics
  10. Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy
    Andrew Gregory, Ahmed M. Awad, Shaimaa Eltanani, Thangal Yumnamcha, Jenna Hart, Rao Me, Xihui Lin, Mohamed Shawky, Ahmed S. Ibrahim · 2025 · Frontiers in Pharmacology
  11. Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics
    Daniyaer Dilimulati, Diyaer Dilimulati, Lei Cui · 2026 · World Journal of Stem Cells
  12. A shift in the cellular redox state redirects aspartate for export under glucose deprivation
    Barbara Konrad, Gabriele Bluemel, Theresa Haitzmann, Tobias Frech, Anke Vandekeere, Mélanie Planque, Visnja Bubalo, Katharina Schindlmaier, Vanessa Jäger, Michael A. Dengler et al. · 2026 · Cancer & Metabolism
  13. HIF-1α drives distinct aspects of hypoxia-induced glucose metabolism in intestinal epithelial cells
    Sarah J. Kierans, Ciarán Kennedy, Rory Turner, Darragh Flood, Emily DeMichele, Martina Wallace, Cormac T. Taylor · 2026 · Journal of Biological Chemistry
  14. Mitochondrial Energy Metabolism in Cancer, Immunoregulation and Antitumour Response
    João S. Patrício, Cindy Mendes, Paulo A. Gameiro · 2026 · Advances in experimental medicine and biology
  15. Tracer-Based Cancer Metabolomic Analysis
    Jianzhou Liu, Jing Li Huang, Gary Guishan Xiao · 2021 · Advances in experimental medicine and biology
  16. Structure and function of bacterial transcription regulators of the SorC family
    Markéta Šoltysová, Pavlína Řezáčová · 2024 · Transcription
  17. IDH2 Inhibitors Gain a Wildcard Status in the Cancer Therapeutics Competition
    Roberto Piva, Nariman Gharari, María Labrador, Sylvie Mader · 2024 · Cancers
  18. In vitroStudies
    Eirini G. Velliou, Eleni Pefani, Susana Brito Dos Santos, María Fuentes‐Garí, Ruth Misener, Nicki Panoskaltsis, Athanasios Mantalaris, Michael C. Georgiadis, Efstratios N. Pistikopoulos · 2017 · Wiley eBooks
  19. The Fate of Glutamine in Human Metabolism. The interplay with glucose in proliferating cells
    Jean‐Pierre Mazat, Stéphane Ransac · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Cell-to-cell variability in AMPK activation reveals autonomous cycles in cellular energy balance
    Nont Kosaisawe, Breanne Sparta, Michael Pargett, Carolyn Teragawa, John G. Albeck · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
    Megan M. Sperry, Bérénice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani T. Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity
    Eduardo Hideo Gilglioni, Ao Li, Wadsen St‐Pierre‐Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Gayane Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá‐Martinez et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
    Megan M. Sperry, Bérénice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani T. Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski et al. · 2024 · eLife
  24. Sequestration of the polyunsaturated fatty acids protects the cells with oxidative phosphorylation deficiency from ferroptosis
    Guillermo Puertas-Frias, María José Saucedo-Rodríguez, Kristýna Čunátová, Lukáš Alán, Patrik Hrbac, Michal Knězů, Sona Konickova, Jakub Schimmer, Monika Krakovkova, Marek Vrbacký et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation
    Santanu Ghosh, Andrew F. Jarvis, Jordi C. J. Hintzen, Nate R. McKnight, Pedro Costa‐Pinheiro, Noelle H. Nouhgton, Yumi Kim, Alison Jaccard, Scot C. Leary, Paul A. Cobine et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  26. TargetableSignalingPathwayMutationsAreAssociatedwith Malignant Phenotype in IDH-Mutant Gliomas
    Hiroaki Wakimoto, Shota Tanaka, William T. Curry, Franziska Loebel, Dan Zhao, Kensuke Tateishi, Juxiang Chen, Lindsay K. Klofas, Nina Lelic, James C. Kim et al. · 2014 · PMC
  27. The Implication of Antiangiogenic Treatment of Malignancies on Human Metabolism
    Nina Obad, Rolf Bjerkvig · 2017 · Springer eBooks
  28. The role of respiration in supporting cell proliferation
    Dan Y. Gui · 2017 · DSpace@MIT (Massachusetts Institute of Technology)
  29. Investigation of the anti-cancer properties of natural products and synthetic analogues with NQO2 inhibiting potential
    Bukunola Oluyemisi Adegbesan · 2018 · Research Explorer (The University of Manchester)
  30. Sarah-Maria Fendt: Driving scientific discovery through collaboration
    Stephanie A. Houston · 2019 · The Journal of Experimental Medicine
  31. Metabolic Regulation of Ferroptosis in Pancreatic Cancer
    Daniel M. Kremer · 2020 · Deep Blue (University of Michigan)
  32. Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway
    Peng Wei, Alex J. Bott, Ahmad A. Cluntun, Jeffrey T. Morgan, Corey Nathaniel Cunningham, John C. Schell, Yeyun Ouyang, Scott B. Ficarro, Jarrod A. Marto, Nika N. Danial et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler
    Haowen Jiang, Rachel L. Greathouse, Bo He, Yang Li, Albert Mao Li, Balint Laszlo Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  34. The Implication of Anti-angiogenic Treatment of Malignancies on Human Metabolism
    Nina Obad, Rolf Bjerkvig · 2019 · Springer eBooks
  35. Metabolic reprogramming of OPA1-deficient cells
    Wenting Dai, Zhichao Wang, Qiong A Wang, David C. Chan, Lei Jiang · 2022 · Research Square
  36. FASN-Deficiency Induces a Cytosol-to-Mitochondria Citrate Flux to Mitigate Oxidative Stress During Metastatic Transition
    Wenting Dai, Zhichao Wang, Guan Wang, Qiong A Wang, Ralph J. DeBerardinis, Lei Jiang · 2022 · SSRN Electronic Journal
  37. A Case Study of De-Staging and Reverse Transformation of a IDH Mutated Malignant Metastatic Sarcoma to Benign Tumor and Complete Clinical Remission by Application of Multi Targeted Epigenetic Therapies
    Mohammad Amin Nezami · 2022 · Progress in Medical Sciences
  38. Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming
    Yongxing Wang, Vikram V. Kulkarni, Jezreel Pantaleón García, Miguel M. Leiva‐Juárez, David L. Goldblatt, Fahad Gulraiz, Jichao Chen, Sri Ramya Donepudi, Philip L. Lorenzi, Hao Wang et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  39. La reprogramación metabólica inducida por patrones moleculares de la pared fúngica regula la expresión de citoquinas
    Cristina Mancebo Tejera · 2023
  40. Metabolic Quadrivalency in RSeT Human Embryonic Stem Cells
    Kevin G. Chen, Kyeyoon Park, Dragan Maric, Kory R. Johnson, Pamela Gehron Robey, Barbara S. Mallon · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Mitochondrial Raf1 Regulates Glutamine Catabolism
    Ronald L. Shanderson, Ian Ferguson, Zurab Siprashvili, Luca Ducoli, Albert Mao Li, Weili Miao, Suhas Srinivasan, Mary Grace M. Velasco, Yang Li, Jiangbin Ye et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Investigating the role of mitochondrial energy rewiring throughout prostate cancer progression
    Charles L. Bidgood · 2023 · Queensland University of Technology
  43. Optimization of Fermentation and Transcriptomic Analysis: The Impact of Aspartic Acid on the Antioxidant Activity of Termitomyces
    Jingfei Zhou, Wenhui Yi, Yunfan Yang, Jiahui Peng, Wujie Zhong, Xuefeng Xu · 2025 · Fermentation
  44. Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response
    Uğur Kahya, Vasyl Lukiyanchuk, Ielizaveta Gorodetska, Matthias M Weigel, Ayşe Sedef Köseer, Berke Alkan, Dragana Savic, Annett Linge, Steffen Löck, Mirko Peitzsch et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Absolute quantification of TCA cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism
    Cloe Ratliff, David Hansman, Tuan Ngo, Yinxiao Xiang, Artjola Puja, Mark Eminhizer, Jinyu Lu, Isabella Mascari, Diana Alabdallat, Jianhai Du · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Alginate/PEG-Fe 3 O 4 hydrogel augmented cryoablation for synergistic tumor suppression
    Ping Ye, Wencong Peng, Yufan Wu, Man Zhang, Ling Du, Yongming Han, Congshuo Chen, Fangli Cao, Qianyun Tang, Bin Gu · 2025 · Nano Research
  47. Additional file 3 of Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data
    Kumar, Avi, Jack Mitchener, Zachary A. King, Christian M. Metallo · 2020 · Figshare
  48. Additional file 2 of Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
    Sinthu Pathmanapan, Olga Ilkayeva, Martin, John T., Loe, Adrian Kwan Ho, Hongyuan H. Zhang, Zhang, Guo-Fang, Christopher B. Newgard, Jay S. Wunder, Benjamin Aaron Alman · 2021 · Figshare
  49. Additional file 3 of Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
    Sinthu Pathmanapan, Olga Ilkayeva, Martin, John T., Loe, Adrian Kwan Ho, Hongyuan H. Zhang, Zhang, Guo-Fang, Christopher B. Newgard, Jay S. Wunder, Benjamin Aaron Alman · 2021 · Figshare
  50. Additional file 1 of Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
    Sinthu Pathmanapan, Olga Ilkayeva, Martin, John T., Loe, Adrian Kwan Ho, Hongyuan H. Zhang, Zhang, Guo-Fang, Christopher B. Newgard, Jay S. Wunder, Benjamin Aaron Alman · 2021 · Figshare
  51. MCJ modulates mitochondrial ETC flux to promote lipid metabolism–driven enhancement of cell proliferation and migration
    Priyadarshika Pradhan, Tanvi Chaudhary, Shivali Mishra, Peter Koník, Eva Ďurinová, Roman Tůma, Abhijit De, Devanjan Sinha · 2026 · Cell Death and Disease
  52. Absolute quantification of tricarboxylic acid (TCA) cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism
    Cloe Ratliff, David Hansman, Tuan Ngo, Yinxiao Xiang, Artjola Puja, Mark Eminhizer, Jinyu Lu, Isabella Mascari, Diana Alabdallat, Jianhai Du · 2026 · Eye Discovery
  53. Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation
    Rebekah L. Mokry, Caleb B de Lacy, John G. Purdy · 2026 · PLoS Pathogens
  54. PGC-1α régule un programme onco-métabolique capable de réprimer l’agressivité du cancer de la prostate
    Lisa Kaminski · 2018 · theses.fr (ABES)
  55. Rôle du transporteur mitochondrial UCP2 dans la leucémie
    Tiphaine Sancerni · 2019
  56. Profilage métabolique et immunitaire aux différents stades de la carcinogenèse cutanée
    P Michon · 2022
  57. FGFR1 drives metabolic adaptation associated with temozolomide resistance in glioblastoma
    Laura Zarzuela, Ignacio G. López-Cepero, Kevin M. Rattigan, Ana Reina-Bando, Jorge Martín-Montalvo, Jesús María Sierra-Párraga, Elena Sánchez-Escabias, Macarena Morillo‐Huesca, Sara S. Oltra, María Ceballos-Chávez et al. · 2026 · Cancer Letters
  58. Mitochondrial transfer-mediated metabolic reprogramming and drug resistance in bone metastasis: mechanisms and therapeutic strategies
    Wei Deng, B Q Liu, Songtao Xiang · 2026 · Frontiers in Immunology
  59. Polyunsaturated fatty acid sequestration protects against mitochondrial dysfunction-induced ferroptosis
    Guillermo Puertas-Frias, María José Saucedo-Rodríguez, Kristýna Čunátová, Lukáš Alán, Patrik Hrbac, Michal Knězů, Sona Konickova, Jakub Schimmer, Monika Krakovkova, Marek Vrbacký et al. · 2026 · EMBO Reports
  60. Novel Insights into the Biochemistry of Citrate and Its Transporters: Relevance to Metabolic Rewiring, Tumor Microenvironment, and Bone Metastasis in Cancer
    Vadivel Ganapathy, Sathish Sivaprakasam, Yangzom D. Bhutia, Puttur Devi Prasad, Muthusamy Thangaraju · 2026 · Cells
  61. Mitochondrial Raf1 regulates glutamine catabolism
    Ronald L. Shanderson, Ian Ferguson, Luca Ducoli, Weili Miao, Suhas Srinivasan, Zurab Siprashvili, Albert Mao Li, Mary Grace M. Velasco, Yang Li, Christine N. Hoang et al. · 2026 · Cell Reports
  62. Divergent Hypoxia-Inducible Factor 2-Alpha Signaling in Alcoholic Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease
    Ayantika Santra, Subhasish Maity, Gouthami Kuruvalli, Selvam Arjunan, Saraladevi Selvam, Challaraj Emmanuel ES, Vaddi Damodara Reddy · 2026 · ACS Pharmacology & Translational Science
  63. Endothelial SLC25A13 links glutamine metabolism to angiogenesis
    Abhishek Subramanian, Anne Cuypers, Patricia Yagüe, Mathias Declercq, Joris Souffreau, Pieter-Jan Coolen, Liliana Sokol, Anh-Co Truong, Mila Borri, Koen Veys et al. · 2026 · EMBO Molecular Medicine
  64. Genetic modulation of NAD(P)H homeostasis reveals distinct redox-coupled metabolic vulnerabilities
    Xingxiu Pan, Austin L. Zuckerman, Karl N. Miller, Marcos G. Teneche, Subrata Munan, Andrew Pon, Niklas B. Thompson, Rasangi M. Perera, Roya AminiTabrizi, Adarsh Rajesh et al. · 2026 · Nature Metabolism