Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation

Cai, Yihua, Xue, Feng, Fleming, Chris, Yang, Jie, Ding, Chuanlin, Ma, Yunfeng, Liu, Min, Zhang, Huang-ge +3 more·2014·Nature Communications

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  8. γδ T cells come to stay: Innate skin memory in the Aldara model
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  17. Dermal Vγ4+T cells enhance the IMQ-induced psoriasis-like skin inflammatidon in re-challenged mice.
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    Natsumi Takayama, Koyomi Shiraishi, Ako Matsui, Shinya Hatano, Kazuhiko Yamamuro, Kenta Nitahara, Akira Makino, Tatsuya Yokota, Nesta Amagiri, Mahiro Watanabe et al. · 2026 · Science Immunology
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    Rumeysa Yegin, A Ahmed, Gulam Hekimoğlu · 2023 · Medical Records
  44. Transcriptional and Microenvironmental Regulation of γδ T Cell Development
    Tracy S. H. In, Michele Kay Anderson · 2016 · Elsevier eBooks
  45. Information models for connectivity in electronic design
    Günter Schlageter, Gerhard Scholz, Wolfgang Wilkes · 1991 · FernUniversität eBooks
  46. The role of T cell subsets in experimental autoimmune encephalomyelitis
    Sarah C. Edwards · 2015 · Arrow@dit (Dublin Institute of Technology)
  47. Microbiota activated CD103 DCS stemming from oral microbiota adaptation specifically drive T17 proliferation and activation.
    Christopher Fleming · 2016
  48. Differential regulation of CD8 + CD86 + Vγ1.1 + γδT cell responses in skin barrier tissue protection and homeostatic maintenance
    Chao Richard Li, Yang‐Ding Lin, Wei‐Bei Wang, Ming Xu, Nu Zhang, Na Xiong · 2022 · European Journal of Immunology
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  50. Role of γδ T Lymphocytes in the Pathogenesis of Autoimmune Diseases with Skin Lesions
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  53. Additional file 1 of Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1β/CXCL2/neutrophil axis
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  54. Drug screening identifies Src/Abl inhibitor dasatinib as suppressor of IL-23 signaling in skin inflammation
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  56. Activation des lymphocytes T gamma delta dans les cancers
    Chloé Laplagne · 2020 · theses.fr (ABES)
  57. Study of the Immune regulation in psoriatic skin and the inflammatory microenvironment in melanoma
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  58. High Fat Diet‐Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss
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