Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Whitehead, Kathryn A., Dorkin, J. Robert, Vegas, Arturo J., Chang, Philip H., Veiseh, Omid, Matthews, Jonathan, Fenton, Owen S., Zhang, Yunlong +8 more·2014·Nature Communications
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- A Collaborative Assembly Strategy for Tumor-Targeted siRNA DeliveryQiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Neng Ping, Ran Mo, Can Zhang · 2015 · Journal of the American Chemical Society
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- Lipid nanocarriers for microRNA deliveryMarcel Scheideler, Ivan Vidaković, Ruth Prassl · 2019 · Chemistry and Physics of Lipids
- Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNAChunhui Li, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, Abid Hussain et al. · 2021 · Nano Letters
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- Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter MouseKevin J. Kauffman, Matthias A. Oberli, J. Robert Dorkin, Juan E. Hurtado, James C. Kaczmarek, Shivani Bhadani, Jeff Wyckoff, Róbert Langer, Ana Jaklenec, Daniel G. Anderson · 2017 · Molecular Therapy — Nucleic Acids
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- A single methylene group in oligoalkylamine‐based cationic polymers and lipids promotes enhanced mRNA deliveryJarzębińska, Anita, Pasewald, Tamara, Lambrecht, Jana, Mykhaylyk, Olga, Kümmerling, Linda, Beck, Philipp, Hasenpusch, Günther, Rudolph, Carsten, Plank, Christian, Dohmen, Christian · 2016 · Angewandte Chemie International Edition
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- Cationic liposome–nucleic acid complexes for gene delivery and gene silencingCyrus R. Safinya, Kai K. Ewert, Ramsey N. Majzoub, Cecília Leal · 2014 · New Journal of Chemistry
- Recent advances in siRNA delivery for cancer therapy using smart nanocarriersPenghui Zhang, Keli An, Xiaoman Duan, Hao Xu, Fei Li, Feng Xu · 2018 · Drug Discovery Today
- Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugsYamin Li, Zhongfeng Ye, Hanyi Yang, Qiaobing Xu · 2022 · Acta Pharmaceutica Sinica B
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- Lipid Nanoparticles for Delivery of Therapeutic RNA OligonucleotidesKeith Henry Moss, Petya G. Popova, Sine Reker Hadrup, Kira Astakhova, Maria Taskova · 2019 · Molecular Pharmaceutics
- Exosome-based small RNA delivery: Progress and prospectsLu, Mei, Xing, Haonan, Xun, Zhe, Yang, Tianzhi, Ding, Pingtian, Cai, Cuifang, Wang, Dongkai, Zhao, Xiaoyun · 2018 · Asian Journal of Pharmaceutical Sciences
- A Nanoprimer To Improve the Systemic Delivery of siRNA and mRNANell Saunders, Marion S. Paolini, Owen S. Fenton, Laurence Poul, Julie Devallière, Francis Mpambani, Audrey Darmon, Maxime Bergère, Océane Jibault, Matthieu Germain et al. · 2020 · Nano Letters
- Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA deliveryJilian R. Melamed, Khalid A. Hajj, Namit Chaudhary, Daria Strelkova, Mariah Lynn Arral, Norbert Pardi, Mohamad‐Gabriel Alameh, Jason B. Miller, Lukas Farbiak, Daniel J. Siegwart et al. · 2021 · Journal of Controlled Release
- In Situ shRNA Synthesis on DNA–Polylactide Nanoparticles to Treat Multidrug Resistant Breast CancerQianqian Ni, Fuwu Zhang, Yunlei Zhang, Guizhi Zhu, Zhe Wang, Zhaogang Teng, Chunyan Wang, Bryant C. Yung, Gang Niu, Guangming Lu et al. · 2018 · Advanced Materials
- Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemiaBo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong et al. · 2022 · Science Advances
- Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivoXuexiang Han, Mohamad‐Gabriel Alameh, Ningqiang Gong, Lulu Xue, Majed Ghattas, Goutham Bojja, Junchao Xu, Gan Zhao, Claude C. Warzecha, Marshall Scott Padilla et al. · 2024 · Nature Chemistry
- History of Polymeric Gene Delivery SystemsPeng Zhang, Ernst Wagner · 2017 · Topics in Current Chemistry
- Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticlesYamin Li, Justin Bolinger, Yingjie Yu, Zachary Glass, Nicola Shi, Liu Yang, Ming Wang, Qiaobing Xu · 2018 · Biomaterials Science
- Evolution of nanomedicine formulations for targeted delivery and controlled releaseSanyogitta Puri, Mariarosa Mazza, Gourgopal Roy, R. England, Liping Zhou, Saghar Nourian, J. Anand Subramony · 2023 · Advanced Drug Delivery Reviews
- Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly( l -lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer TherapyXiaoyan Zhou, Qianqian Zheng, Changyong Wang, Jiake Xu, Jianping Wu, T.B. Kirk, Dong Ma, Wei Xue · 2016 · ACS Applied Materials & Interfaces
- Recent Advances in RNA Therapeutics and RNA Delivery Systems Based on NanoparticlesHojeong Shin, S.D. Park, Yeajee Yim, Jungho Kim, Chulwon Choi, Cheolhee Won, Dal‐Hee Min · 2018 · Advanced Therapeutics
- Designing lipid nanoparticles using a transformer-based neural networkAlvin Chan, Ameya R. Kirtane, Qing Rui Qu, Xisha Huang, Jonathan Woo, Deepak A. Subramanian, Rajib Dey, Rika Semalty, Joshua D. Bernstock, Taksim Ahmed et al. · 2025 · Nature Nanotechnology
- In vivo fate of lipid-based nanoparticlesJianping Qi, Jie Zhuang, Yi Lü, Xiaochun Dong, Weili Zhao, Wei Wu · 2016 · Drug Discovery Today
- Branching Ionizable Lipids Can Enhance the Stability, Fusogenicity, and Functional Delivery of mRNAKazuki Hashiba, Yusuke Sato, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Takuya Shishido, Masao Murakawa, Okazaki Arimichi, Hideyoshi Harashima · 2022 · Small Science
- Synthetic Nucleic Acid Delivery Systems: Present and PerspectivesBogdan Draghici, Marc Antoniu Ilies · 2015 · Journal of Medicinal Chemistry
- Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cellsYunfeng Yan, Li Liu, Hu Xiong, Jason B. Miller, Kejin Zhou, Petra Kós, Kenneth E. Huffman, Sussana A. Elkassih, John W. Norman, Ryan M. Carstens et al. · 2016 · Proceedings of the National Academy of Sciences
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- Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic proteinNigel M. Davies, Daniel Hovdal, Nicholas J. Edmunds, Peter Nordberg, Anders Dahlén, Aleksandra P. Dabkowska, Marianna Yanez Arteta, Aurel Rădulescu, Tomas Kjellman, Andreas Höijer et al. · 2021 · Molecular Therapy — Nucleic Acids
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- Lipid nanoparticles silence tumor necrosis factor α to improve wound healing in diabetic miceLisa N. Kasiewicz, Kathryn A. Whitehead · 2018 · Bioengineering & Translational Medicine
- Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeuticsLee Soo Hyeon, Yoon Young Kang, Hyo-Eun Jang, Hyejung Mok · 2015 · Advanced Drug Delivery Reviews
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- In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editorsXuexiang Han, Junchao Xu, Ying Xu, Mohamad‐Gabriel Alameh, Lulu Xue, Ningqiang Gong, Rakan D. El-Mayta, Rohan Palanki, Claude C. Warzecha, Gan Zhao et al. · 2024 · Nature Communications
- Path-programmable water droplet manipulations on an adhesion controlled superhydrophobic surfaceJungmok Seo, Seoung-Ki Lee, Jaehong Lee, Jung Seung Lee, Hyukho Kwon, Seung‐Woo Cho, Jong‐Hyun Ahn, Taeyoon Lee · 2015 · Scientific Reports
- Developing Small Activating RNA As a Therapeutic: Current Challenges and PromisesAlbert Kwok, Nina Raulf, Nagy Adley Habib · 2019 · Therapeutic Delivery
- Gene Therapy for Human Sensorineural Hearing LossYin Ren, Lukas David Landegger, Konstantina M. Stanković · 2019 · Frontiers in Cellular Neuroscience
- pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic ReleaseJunhui Zhou, Yidi Wu, Changrong Wang, Qiang Cheng, Shangcong Han, Xiaoxia Wang, Jianhua Zhang, Liandong Deng, Deyao Zhao, Lili Du et al. · 2016 · Nano Letters
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- Enzyme-Responsive Charge-Reversal Polymer-Mediated Effective Gene Therapy for Intraperitoneal TumorsNasha Qiu, Jianqing Gao, Qi Liu, Jinqiang Wang, Youqing Shen · 2018 · Biomacromolecules
- Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editingHao Tang, Xiaohui Zhao, Xingyu Jiang · 2020 · Advanced Drug Delivery Reviews
- Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid NanoparticlesLi, Yamin, Jarvis, Rachel, Zhu, Kuixin, Glass, Zachary, Ogurlu, Roza, Gao, Peiyang, Li, Peixuan, Chen, Jinjin, Yu, Yingjie, Yang, Yongjie et al. · 2020 · Angewandte Chemie International Edition
- Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 VaccinesZhongyu Li, Xue‐Qing Zhang, William Ho, Fengqiao Li, Mingzhu Gao, Xin Bai, Xiaoyang Xu · 2022 · ACS Nano
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- Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle deliveryZhao Gan, Lulu Xue, Hannah C. Geisler, Junchao Xu, Xinyuan Li, Michael J. Mitchell, Andrew E. Vaughan · 2024 · Proceedings of the National Academy of Sciences
- Nano-therapeutics for modulating the tumour microenvironment: Design, development, and clinical translationSiddharth Adityan, Michelle A. Tran, Chintan Bhavsar, Sherry Y. Wu · 2020 · Journal of Controlled Release
- Biomaterials for in situ cell therapyChang Wang, Siyu Wang, Diana D. Kang, Yizhou Dong · 2023 · BMEMat
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- Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolutionXuexiang Han, Mohamad‐Gabriel Alameh, Ying Xu, Rohan Palanki, Rakan D. El-Mayta, Garima Dwivedi, Kelsey L. Swingle, Junchao Xu, Ningqiang Gong, Lulu Xue et al. · 2024 · Nature Biomedical Engineering
- Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and CrossingHan, Emily L., Padilla, Marshall S., Palanki, Rohan, Kim, Dongyoon, Mrksich, Kaitlin, Li, Jacqueline J., Tang, Sophia, Yoon, Il-Chul, Mitchell, Michael J. · 2024 · Nano Letters
- Application of targeted therapy strategies with nanomedicine delivery for atherosclerosisLe-chun Ou, Shan Zhong, Jing‐Song Ou, Jinwei Tian · 2020 · Acta Pharmacologica Sinica
- siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivoSuzuki, Y., Hyodo, K., Tanaka, Y., Ishihara, H. · 2015 · Journal of Controlled Release
- In vivo fate and intracellular trafficking of vaccine delivery systemsJaiwoo Lee, Dongyoon Kim, Junho Byun, Yina Wu, Jin-Won Park, Yu‐Kyoung Oh · 2022 · Advanced Drug Delivery Reviews
- Non-viral nanoparticles for RNA interference: Principles of design and practical guidelinesZehua Liu, Shiqi Wang, Christos Tapeinos, Giulia Torrieri, Voitto Känkänen, Nesma El‐Sayed, André Python, Jouni J. Hirvonen, Hélder A. Santos · 2021 · Advanced Drug Delivery Reviews