The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Bacterial killing via a type IV secretion system
Open accessAbstract
Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein–DNA complexes through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. Many bacteria of the family Xanthomonadaceae, which occupy diverse environmental niches, carry a T4SS with unknown function but with several characteristics that distinguishes it from other T4SSs. Here we show that the Xanthomonas citri T4SS provides these cells the capacity to kill other Gram-negative bacterial species in a contact-dependent manner. The secretion of one type IV bacterial effector protein is shown to require a conserved C-terminal domain and its bacteriolytic activity is neutralized by a cognate immunity protein whose 3D structure is similar to peptidoglycan hydrolase inhibitors. This is the first demonstration of the involvement of a T4SS in bacterial killing and points to this special class of T4SS as a mediator of both antagonistic and cooperative interbacterial interactions. Bacterial secretion systems deliver proteins to the extracellular milieu or directly into the cytoplasm of other cells. Here Souza et al. show that a type IV secretion system (T4SS) allows Xanthomonas citrito kill other Gram-negative bacterial species in a contact-dependent manner.
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Xanthomonas diversity, virulence and plant–pathogen interactions
Timilsina, S., Potnis, N., Newberry, E. A., Liyanapathiranage, P., Iruegas-Bocardo, F., White, F. F., Goss, E. M., & Jones, J. B. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0361-8 · Cited by 396
Bacterial antagonism in host-associated microbial communities
García-Bayona, L., & Comstock, L. E. (2018) · Science · doi:10.1126/science.aat2456 · Cited by 373
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Metadata
- Authors
- Souza, D. P., Oka, G. U., Alvarez-Martinez, C. E., Bisson-Filho, A. W., Dunger, G., Hobeika, L., Cavalcante, N. S., Alegria, M. C., Barbosa, L. R. S., Salinas, R. K., Guzzo, C. R., & Farah, C. S.
- Venue
- Nature Communications
- Published
- 2015-03-06
- Volume
- 6
- Issue
- 1
- Pages
- 6453-6453
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2073690728
- Cited by
- 271
- References
- 65
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Souza, D. P., Oka, G. U., Alvarez-Martinez, C. E., Bisson-Filho, A. W., Dunger, G., Hobeika, L., Cavalcante, N. S., Alegria, M. C., Barbosa, L. R. S., Salinas, R. K., Guzzo, C. R., & Farah, C. S. (2015). Bacterial killing via a type IV secretion system. Nature Communications. https://doi.org/10.1038/ncomms7453
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