The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Open accessAbstract
Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and C/EBP homology protein (CHOP). Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN. sXBP1 lies downstream of insulin signalling and attenuating podocyte insulin signalling by genetic ablation of the insulin receptor or the regulatory subunits phosphatidylinositol 3-kinase (PI3K) p85α or p85β impairs sXBP1 nuclear translocation and exacerbates DN. Corroborating our findings from murine DN, the interaction of sXBP1 with p85α and p85β is markedly impaired in the glomerular compartment of human DN. Thus, signalling via the insulin receptor, p85, and XBP1 maintains podocyte homeostasis, while disruption of this pathway impairs podocyte function in DN.
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Cites
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2738 · Cited by 1,691
Yoshida, H., Okada, T., Haze, K., Yanagi, H., Yura, T., Negishi, M., & Mori, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6755-6767.2000 · Cited by 934
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
Gödel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mór, A., Lindenmeyer, M. T., Rastaldi, M.-P., Hartleben, G., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44774 · Cited by 547
Cited by
Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases
Cybulsky, A. V. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.129 · Cited by 526
The impact of insulin resistance on the kidney and vasculature
Artunc, F., Schleicher, E., Weigert, C., Fritsche, A., Stefan, N., & Häring, H.-U. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 462
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms
Gnudi, L., Coward, R. J. M., & Long, D. A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.07.002 · Cited by 332
Shahzad, K., Gadi, I., Nazir, S., Al-Dabet, M. M., Kohli, S., Bock, F., Breitenstein, L., Ranjan, S., Fuchs, T., Halloul, Z., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0108-5 · Cited by 40
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Metadata
- Authors
- Madhusudhan, T., Wang, H., Dong, W., Ghosh, S., Bock, F., Thangapandi, V. R., Ranjan, S., Wolter, J., Kohli, S., Shahzad, K., Heidel, F., Krueger, M., Schwenger, V., Moeller, M. J., Kalinski, T., Reiser, J., Chavakis, T., & Isermann, B.
- Venue
- Nature Communications
- Published
- 2015-03-10
- Volume
- 6
- Issue
- 1
- Pages
- 6496-6496
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1976496691
- Cited by
- 181
- References
- 3
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Madhusudhan, T., Wang, H., Dong, W., Ghosh, S., Bock, F., Thangapandi, V. R., Ranjan, S., Wolter, J., Kohli, S., Shahzad, K., Heidel, F., Krueger, M., Schwenger, V., Moeller, M. J., Kalinski, T., Reiser, J., Chavakis, T., & Isermann, B. (2015). Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nature Communications. https://doi.org/10.1038/ncomms7496
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