The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms
Open accessAbstract
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the renin-angiotensin-aldosterone system, on glycaemic and lipid control, and life-style changes. In this review, we highlight new molecular insights aiding our understanding of the initiation and progression of DN, including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication, and inhibition of tubular sodium coupled glucose reabsorption. We believe that these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for DN over the next decade.
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Cited by
Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30051-2 · Cited by 2,335
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363
Sex differences in micro- and macro-vascular complications of diabetes mellitus
Maric-Bilkan, C. (2017) · Clinical Science · doi:10.1042/cs20160998 · Cited by 217
Huang, K., Gao, X., & Wei, W. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.042 · Cited by 155
Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases
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Metadata
- Authors
- Gnudi, L., Coward, R. J. M., & Long, D. A.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 27
- Issue
- 11
- Pages
- 820-830
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2506940170
- Cited by
- 332
- References
- 88
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Gnudi, L., Coward, R. J. M., & Long, D. A. (2016). Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2016.07.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
