Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe +7 more·2015·Nature Communications
Cited by (1,000)
Items 301–400 of 1,000
- Advances in Molecular Profiling and Categorisation of Pancreatic Adenocarcinoma and the Implications for TherapyRille Pihlak, Jamie M. J. Weaver, Juan W. Valle, Mairead Geraldine McNamara · 2018 · Cancers
- Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine ProfilingEmily S. Humphrey, Shih‐Ping Su, Adnan M. Nagrial, Falko Hochgräfe, Marina Pajic, Gillian M. Lehrbach, Robert G. Parton, Alpha S. Yap, Lisa Glen Horvath, David Kuang-Fu Chang et al. · 2016 · Molecular & Cellular Proteomics
- Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progressionKohei Fujikura, Masayuki Akita, Shiho Abe‐Suzuki, Tomoo Itoh, Yoh Zen · 2017 · Histopathology
- Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancerF. Graeme Frost, Praveen F. Cherukuri, Samuel J. Milanovich, Cornelius F. Boerkoel · 2019 · Journal of Cellular and Molecular Medicine
- Analysis pipelines for cancer genome sequencing in miceSebastian Lange, Thomas Engleitner, Sebastian Mueller, Roman Maresch, Maximilian Zwiebel, Laura González-Silva, Günter Schneider, Ruby Banerjee, Fengtang Yang, George S. Vassiliou et al. · 2020 · Nature Protocols
- Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancerFrank, Katrin J., Mulero-Sánchez, Antonio, Berninger, Alexandra, Ruiz-Cañas, Laura, Bosma, Astrid, Görgülü, Kıvanç, Wu, Nan, Diakopoulos, Kalliope N., Kaya-Aksoy, Ezgi, Ruess, Dietrich A. et al. · 2022 · Cell Reports Medicine
- A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancerCorina E. Antal, Tae Gyu Oh, Stefan Aigner, En‐Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Cheng Zhang, Henry Jiao et al. · 2023 · Nature Communications
- Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancerVishnu Muthuraj Kumarasamy, Amanda Ruiz, Ram Nambiar, Agnieszka Katarzyna Witkiewicz, Erik S. Knudsen · 2019 · Oncogene
- Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer: Results From a Multicenter, Prospective, Universal Genetic Testing StudyPedro Luiz Serrano Usón, Niloy Jewel Samadder, Douglas L. Riegert‐Johnson, Lisa Boardman, Mitesh J. Borad, Daniel H. Ahn, Mohamad Bassam Sonbol, Douglas O. Faigel, Norio Fukami, Rahul Pannala et al. · 2021 · Clinical and Translational Gastroenterology
- Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapiesAnthony Turpin, Cindy Neuzillet, Elise Colle, Nelson Dusetti, Rémy Nicolle, Jerome F. Cros, Louis de Mestier, Jean‐Baptiste Bachet, Pascal R. Hammel · 2022 · Therapeutic Advances in Medical Oncology
- Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentialsMingjie Jiang, Juanjuan Dai, Dian-na Gu, Qian Huang, Ling Tian · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusionKatherine M. Collins, Yaroslav A. Kainov, Evangelos Christodoulou, Debashish Ray, Quaid Morris, Timothy R. Hughes, Ian A. Taylor, Eugene V. Makeyev, Andres Ramos · 2017 · Nucleic Acids Research
- BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in miceStephanie Perkail, Jaclyn Andricovich, Kai Yan, Alexandros Tzatsos · 2020 · Nature Communications
- Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity inKRASwild-type tumorsWilliam Berry, Elizabeth M. Algar, Beena Kumar, Christopher Desmond, Michael P. Swan, Brendan John Jenkins, Daniel Gerald Croagh · 2017 · International Journal of Cancer
- Biological characteristics of pancreatic ductal adenocarcinoma: Initiation to malignancy, intracellular to extracellularOu Li, Li Li, Yunru Sheng, Kun Ke, Jianzhang Wu, Yiping Mou, Mingyang Liu, Weiwei Jin · 2023 · Cancer Letters
- Long-term survivors of pancreatic adenocarcinoma show low rates of genetic alterations in KRAS, TP53 and SMAD4Michele Masetti, Giorgia Acquaviva, Michela Visani, Giovanni Tallini, Adele Fornelli, Moira Ragazzi, Francesco Vasuri, Daniela Grifoni, Simone Di Giacomo, Sirio Fiorino et al. · 2017 · Cancer Biomarkers
- Ultrasensitive plasma ctDNA KRAS assay for detection, prognosis, and assessment of therapeutic response in patients with unresectable pancreatic ductal adenocarcinomaInna Markovna Chen, Victoria M. Raymond, Jennifer A. Geis, Eric Andrew Collisson, Benny Vittrup Jensen, Kirstine Lintrup Hermann, Mark G. Erlander, Margaret A. Tempero, Julia Sidenius Johansen · 2017 · Oncotarget
- Loss of ARID1A Expression Correlates With Tumor Differentiation and Tumor Progression Stage in Pancreatic Ductal AdenocarcinomaLi Zhang, Cuiping Wang, Shuangni Yu, Congwei Jia, Jie Yan, Zhaohui Lu, Jie Chen · 2018 · Technology in Cancer Research & Treatment
- Patterns of Cause-Specific Mortality Among 2053 Survivors of Retinoblastoma, 1914–2016Ruth A. Kleinerman, Margaret Anne Tucker, Byron S. Sigel, David H. Abramson, Johanna M. Seddon, Lindsay McOmber Morton · 2018 · JNCI Journal of the National Cancer Institute
- Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping reviewRitu Singh, Johanna Goldberg, Anna M. Varghese, Kenneth H. Yu, Wungki Park, Eileen Mary O'Reilly · 2019 · Cancer Treatment Reviews
- Behind the Wheel of Epithelial Plasticity in KRAS-Driven CancersEmily Nicole Arner, Wenting Du, Rolf A. Brekken · 2019 · Frontiers in Oncology
- Genomic Heterogeneity of Pancreatic Ductal Adenocarcinoma and Its Clinical ImpactMaría Laura Gutiérrez, Luis Muñoz‐Bellvís, Alberto Órfão · 2021 · Cancers
- Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse ModelsSaiki, Yuriko, Jiang, Can, Ohmuraya, Masaki, Furukawa, Toru · 2021 · Cancers
- Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment ResistanceKendelle Joan Murphy, Cecilia R. Chambers, David Herrmann, Paul Timpson, Brooke Pereira · 2021 · Cancers
- The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand–dependent Cancer ModelsCaroline Phillips, Inder Bhamra, Catherine Eagle, Eimear Flanagan, Richard E Armer, Clifford D. Jones, Matilda J. Bingham, Peter J. Calcraft, Alicia Edmenson Cook, Ben Thompson et al. · 2022 · Cancer Research Communications
- PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK/p65 PathwayYejiao Ruan, Guangrong Lu, Yaojun Yu, Yue Luo, Hao Wu, Yating Shen, Zejun Gao, Yao Shen, Zhenzhai Cai, Liyi Li · 2023 · Current Molecular Pharmacology
- The Use of Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes Mellitus Does Not Increase the Risk of Pancreatic Cancer: A U.S.-Based Cohort StudyMark Ayoub, Carol Faris, Tajana Juranovic, Harleen Kaur Chela, Ebubekir S. Daglilar · 2024 · Cancers
- OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging dataNathalia Luisa Carlos Ferreira, Ajinkya Kulkarni, David Agorku, Teona Midelashvili, Olaf Hardt, Tobias Jörg Legler, Philipp Ströbel, Lena‐Christin Conradi, Frauke Alves, Fernanda Ramos‐Gomes et al. · 2024 · Cellular Oncology
- Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trialJennifer Jane Knox, Gun Ho Jang, Robert C. Grant, Amy Xin Wei Zhang, Lucy X Ma, Elena C. Elimova, Raymond Jang, Malcolm J. Moore, James Joseph Biagi, Mustapha Ali Tehfe et al. · 2025 · Nature Communications
- Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of DiseaseStephen J. Murphy, Steven N. Hart, Geoffrey C. Halling, Sarah H. Johnson, James B. Smadbeck, Travis Drucker, Joema Felipe Lima, Fariborz Rakhshan Rohakhtar, Faye R. Harris, Farhad Kosari et al. · 2015 · Cancer Research
- RTK-RAS pathway mutation is enriched in myeloid sarcomaMihong Choi, Yoon Kyung Jeon, Choong-Hyun Sun, Hongseok Yun, Junshik Hong, Dong‐Yeop Shin, Inho Kim, Sung‐Soo Yoon, Youngil Koh · 2018 · Blood Cancer Journal
- RBM10–TFE3 renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break‐apart fluorescence in‐situ hybridisation: study of 10 cases and a literature reviewIkuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino et al. · 2019 · Histopathology
- The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal AdenocarcinomaHo-June Lee, Trang Pham, Matthew T. Chang, Dwight Barnes, Allen G. Cai, Rajkumar Noubade, Klára Tótpál, Xu Chen, Christopher Tran, Thijs J. Hagenbeek et al. · 2020 · Cancer Research
- MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal AdenocarcinomaBastian Krenz, Anneli Gebhardt-Wolf, Carsten Patrick Ade, Abdallah Gaballa, Florian Roehrig, Emilia Vendelova, Apoorva Baluapuri, Ursula Eilers, Peter Gallant, Luana D’Artista et al. · 2021 · Cancer Research
- ARID1A mutations in cancer development: mechanism and therapyXuewei Zhang, Yixuan Zhang, Jinyi Zhao, Yinjie Wu, Na Zhang, Wenjing Shen · 2023 · Carcinogenesis
- Copy Number Variations in Pancreatic Cancer: From Biological Significance to Clinical UtilityDaisy J. A. Oketch, Matteo Giulietti, Francesco Piva · 2023 · International Journal of Molecular Sciences
- Novel Regulation of Wnt Signaling at the Proximal Membrane LevelXiaomo Jiang, Feng Cong · 2016 · Trends in Biochemical Sciences
- Emerging themes of regulation at the GolgiStefanie L. Makowski, Thuy Thi Thu Tran, Seth J. Field · 2017 · Current Opinion in Cell Biology
- The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulatorsBrajesh Pratap Kaistha, Anja Krattenmacher, Johannes Fredebohm, Harald Schmidt, Diana Behrens, Miriam Widder, Thilo Hackert, Oliver Strobel, Jörg D. Hoheisel, Thomas Mathias Gress et al. · 2017 · Oncotarget
- Vasohibin‐2 plays an essential role in metastasis of pancreatic ductal adenocarcinomaRie Iida‐Norita, Minaho Kawamura, Yasuhiro Suzuki, Shin Hamada, Atsushi Masamune, Toru Furukawa, Yasufumi Sato · 2019 · Cancer Science
- The SUMO pathway in pancreatic cancer: insights and inhibitionChristian Schneeweis, Zonera Hassan, Markus Schick, Ulrich Bernd Keller, Günter Schneider · 2020 · British Journal of Cancer
- Histone methylation in pancreatic cancer and its clinical implicationsXingyu Liu, Chuan-Hao Guo, Zhi-Yuan Xi, Xin-Qi Xu, Qing-Yang Zhao, Lisha Li, Ying Wang · 2021 · World Journal of Gastroenterology
- KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature reviewLei Zhou, Yoshifumi Baba, Yuki Kitano, Keisuke Miyake, Xiaobo Zhang, Kensuke Yamamura, Keisuke Kosumi, Takayoshi Kaida, Kota Arima, Katsunobu Taki et al. · 2016 · Medical Oncology
- Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibitionDustin James Flanagan, Simon A. Woodcock, Caroline Phillips, Catherine Eagle, Owen James Sansom · 2022 · Pharmacology & Therapeutics
- β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancerTzu‐Lei Kuo, Kuang‐Hung Cheng, Yan‐Shen Shan, Li‐Tzong Chen, Wen-Chun Hung · 2018 · Theranostics
- Immunotherapy in pancreatic cancer: New hope or mission impossible?Jiahong Jiang, Huaixiang Zhou, Chao Ni, Xiaoge Hu, Yiping Mou, Dongsheng Huang, Liu Yang · 2019 · Cancer Letters
- Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutationRongqin Ren, Somashekar Gopala Krishna, Wei Chen, Wendy L. Frankel, Rulong Z. Shen, Weiqiang Zhao, Matthew R. Avenarius, Jason P. Garee, Sean Caruthers, Dan M. Jones · 2020 · Modern Pathology
- FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic CancerNorihiko Sasaki, Fujiya Gomi, Hisashi Yoshimura, Masami Yamamoto, Yoko Matsuda, Masaki Michishita, Hitoshi Hatakeyama, Yoichi Kawano, Masashi Toyoda, Murray Korc et al. · 2020 · Cancers
- Recent advances in precision medicine for pancreatic ductal adenocarcinomaHiromitsu Hayashi, Takaaki Higashi, Tatsunori Miyata, Yo‐ichi Yamashita, Hideo Baba · 2021 · Annals of Gastroenterological Surgery
- Imaging phenotype using 18F-fluorodeoxyglucose positron emission tomography–based radiomics and genetic alterations of pancreatic ductal adenocarcinomaChae Hong Lim, Young Seok Cho, Joon Young Choi, Kyung-Han Lee, Jong Kyun Lee, Ji Hye Min, Seung Hyup Hyun · 2020 · European Journal of Nuclear Medicine and Molecular Imaging
- <i>KRAS</i>
Mutation Variants and Co-occurring PI3K Pathway Alterations Impact Survival for Patients with Pancreatic Ductal AdenocarcinomasDiehl, Adam C, Hannan, Lindsay M, Zhen, David B, Coveler, Andrew L, King, Gentry, Cohen, Stacey A, Harris, William P, Shankaran, Veena, Wong, Kit M, Green, Steven et al. · 2022 · The Oncologist
- SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune MicroenvironmentDalin Zhang, Aaron Raymond Lindstrom, Edward Jae-Hoon Kim, Chang‐Il Hwang, Madison Lee Hall, Tzu‐yin Lin, Yuanpei Li · 2022 · Frontiers in Oncology
- Identification by FFPE RNA‐Seq of a new recurrent inversion leading to RBM10‐TFE3 fusion in renal cell carcinoma with subtle TFE3 break‐apart FISH patternPierre‐Alexandre Just, Franck Letourneur, Christelle Pouliquen, Florence Dome, Anne Audebourg, P Biquet, Michel Vidaud, Benoît Terris, Mathilde Sibony, Éric Pasmant · 2016 · Genes Chromosomes and Cancer
- Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagyMargherita Leonardi, Eluisa Perna, Serena Tronnolone, David Colecchia, Mario Chiariello · 2018 · Autophagy
- Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic CancerSejin Chung, Paris J. Vail, Agnieszka Katarzyna Witkiewicz, Erik S. Knudsen · 2018 · Clinical Cancer Research
- Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transitionRyne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter Wright, R Myers, Sara J. Cooper · 2021 · BMC Cancer
- The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylationSean L. Beckwith, Erin K. Schwartz, Pablo E. García-Nieto, Devin A. King, Graeme J. Gowans, Ka Man Wong, Wei Yao, Tessa L. Eckley, Alexander P. Paraschuk, Egan L. Peltan et al. · 2018 · PLoS Genetics
- Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal AdenocarcinomaNebojša Skorupan, Mayrel Palestino Domínguez, Samuel L. Ricci, Christine Alewine · 2022 · Cancers
- Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumorSakue Masuda, Kazuya Koizumi, Kento Shionoya, Ryuhei Jinushi, Makomo Makazu, Takashi Nishino, Karen A. Kimura, Chihiro Sumida, Jun Kubota, Chikamasa Ichita et al. · 2023 · World Journal of Gastroenterology
- The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genesThomas Paul Slavin, Susan L. Neuhausen, Bita Nehoray, Mariana Niell‐Swiller, Ilana B. Solomon, Christina Rybak, Kathleen Reilly Blazer, Aaron W. Adamson, Kai Yang, Sharon R. Sand et al. · 2017 · Familial Cancer
- The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinomaMotoyuki Tsuda, Akihisa Fukuda, Munenori Kawai, Osamu Araki, Hiroshi Seno · 2020 · Cancer Science
- Role of targeted immunotherapy for pancreatic ductal adenocarcinoma (PDAC) treatment: An overviewKanan Panchal, Rakesh Kumar Sahoo, Umesh Dutta Gupta, Akash Chaurasiya · 2021 · International Immunopharmacology
- Circulating tumor DNA as a predictive marker for occult metastases in pancreatic cancer patients with radiographically non‐metastatic diseaseTatsuo Hata, Masamichi Mizuma, Masahiro Iseki, Tatsuyuki Takadate, Masaharu Ishida, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno · 2021 · Journal of Hepato-Biliary-Pancreatic Sciences
- Epigenetic drug screening defines a PRMT5 inhibitor–sensitive pancreatic cancer subtypeFelix Orben, Katharina Lankes, Christian Schneeweis, Zonera Hassan, Hannah Jakubowsky, Lukas Krauß, Fabio Boniolo, Carolin Schneider, Arlett Schäfer, Janine Murr et al. · 2022 · JCI Insight
- SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancerRuizhe He, Juanjuan Shi, Dapeng Xu, Jian Yang, Yang Shen, Yongsheng Jiang, Ling‐Ye Tao, Minwei Yang, Xueliang Fu, Jian‐Yu Yang et al. · 2022 · Cancer Letters
- Mismatch repair (MMR) and microsatellite instability (MSI) phenotypes across solid tumors: A comprehensive cBioPortal study on prevalence and prognostic impactKonstantinos Venetis, Chiara Frascarelli, Luca Boscolo Bielo, Giulia Cursano, Riccardo Adorisio, Mariia D. Ivanova, Eltjona Mane, Virginia Peruzzo, Alberto Concardi, Mariachiara Negrelli et al. · 2025 · European Journal of Cancer
- The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and SignalingAnke Bill, Larry Alex Gaither · 2017 · Advances in experimental medicine and biology
- Functional role of RBM10 in lung adenocarcinoma proliferationXiuna Sun, Mengqi Jia, Wei Sun, Feng Lu, Chundong Gu, Taihua Wu · 2018 · International Journal of Oncology
- Challenges and Future Perspectives of Immunotherapy in Pancreatic CancerAnna Maxi Wandmacher, Anne Letsch, Susanne Sebens · 2021 · Cancers
- RNA-binding proteins of COSMIC importance in cancerPeter S. Choi, Andrei Thomas‐Tikhonenko · 2021 · Journal of Clinical Investigation
- Precision medicine for KRAS wild-type pancreatic adenocarcinomasImen Ben-Ammar, Adrien Rousseau, Rémy Nicolle, Anthony Tarabay, Valérie Boige, Marine Valéry, Thomas Pudlarz, David Malka, Maximiliano Gelli, Elena Fernandez-De-Sevilla et al. · 2023 · European Journal of Cancer
- Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challengesJie Yan, Shuangni Yu, Congwei Jia, Min Li, Jie Chen · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeuticsWalaa E. Kattan, John F. Hancock · 2020 · Biochemical Journal
- Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular OriginM. Reichert, Karin Blume, A. Kleger, D. Hartmann, G. von Figura · 2015 · Stem Cells International
- Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysisJingyi Ding, Yanxi Liu, Yu Lai · 2020 · PeerJ
- Critical role of KRAS mutation in pancreatic ductal adenocarcinomaZhiyao Fan, Kun Fan, Chao Yan, Qiuyi Huang, Yitao Gong, He Cheng, Kaizhou Jin, Chen Liu, Quanxing Ni, Xianjun Yu et al. · 2018 · Translational Cancer Research
- Multi-omic molecular comparison of primary versus metastatic pancreatic tumoursGagandeep Singh Brar, Edik Matthew Blais, R Joseph Bender, Jonathan Robert Brody, Davendra P. S. Sohal, Subha Madhavan, Vincent J. Picozzi, Andrew Eugene Hendifar, Vincent M. Chung, David Halverson et al. · 2019 · British Journal of Cancer
- K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysisTao Li, Yuanting Zheng, Hong Sun, Rongyuan Zhuang, Jing Liu, Tianshu Liu, Weimin Cai · 2016 · Medical Oncology
- Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical ImplicationsBrittany Silverman, Jiaqi Shi · 2016 · International Journal of Molecular Sciences
- Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic FingerprintSören Müller, Aaron A. Diaz · 2017 · Frontiers in Genetics
- K-ras mutation analysis of residual liquid-based cytology specimens from endoscopic ultrasound-guided fine needle aspiration improves cell block diagnosis of pancreatic ductal adenocarcinomaYoko Sekita‐Hatakeyama, Takeshi Nishikawa, Mao Takeuchi, Kouhei Morita, Maiko Takeda, Kinta Hatakeyama, Tokiko Nakai, Tomoko Uchiyama, Hiroe Itami, Tomomi Fujii et al. · 2018 · PLoS ONE
- Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancerJing Du, Yuanqiao He, Weiquan Wu, Peng Li, Youwei Chen, Zhiming Hu, Yong Han · 2019 · Journal of Pharmacy and Pharmacology
- Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival responseFaustino Mollinedo, Consuelo Gajate · 2019 · Annals of Translational Medicine
- ATM Serine/Threonine Kinase and its Role in Pancreatic RiskNeha Nanda, Nicholas Jason Roberts · 2020 · Genes
- Retrospective Case Series Analysis of RAF Family Alterations in Pancreatic Cancer: Real-World Outcomes From Targeted and Standard TherapiesAndrew Eugene Hendifar, Edik Matthew Blais, Brian Matthew Wolpin, Vivek Subbiah, Eric Andrew Collisson, Isha Singh, Timothy Lewis Cannon, Kenna R Mills Shaw, Emanuel F. Petricoin, Samuel Jacob Klempner et al. · 2021 · JCO Precision Oncology
- The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancerJ. Nathaniel Diehl, Jennifer E. Klomp, Kayla R. Snare, Priya S. Hibshman, Devon R. Blake, Zane D. Kaiser, Thomas S.K. Gilbert, Elisa Baldelli, Mariaelena Pierobon, Bjoern Papke et al. · 2021 · Journal of Biological Chemistry
- The Role of SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link?Marie-Lucie Racu, Laetitia Lebrun, Andréa Alex Schiavo, Claude Van Campenhout, Sarah De Clercq, Lara Absil, Esmeralda Minguijón, Calliope Maris, Christine Decaestecker, Isabelle J. Salmon et al. · 2022 · Cancers
- Spatial Transcriptomics Reveals Cancer and Stromal Cell Heterogeneity Between Center and Invasive Front of Pancreatic CancerTine Norman Alver, Helga Bergholtz, Maia Blomhoff Holm, Linda Trobe Dorg, Martina Landschoof Skrede, Elin Hegland Kure, Caroline Sophie Verbeke · 2025 · Modern Pathology
- Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignanciesTrang H. Au, Kai Wang, David Dean Stenehjem, Ignacio Garrido‐Laguna · 2017 · Journal of Gastrointestinal Oncology
- Molecular classification as prognostic factor and guide for treatment decision of pancreatic cancerDavid Jérémie Birnbaum, François Bertucci, Pascal Finetti, Daniel Birnbaum, Émilie Mamessier · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Molecular and Phenotypic Profiling for Precision Medicine in Pancreatic Cancer: Current Advances and Future PerspectivesKoji Miyabayashi, Hayato Nakagawa, Kazuhiko Koike · 2021 · Frontiers in Oncology
- Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growthYihui Sun, Jiaming Xie, Shang Cai, Qian Wang, Zhenyu Feng, Yecheng Li, Jingjing Lu, Wei Chen, Zhenyu Ye · 2021 · Cell Death and Disease
- Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ PathwayYuichi Fukunaga, Akihisa Fukuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa et al. · 2022 · Gastroenterology
- An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation-Negative Pancreatic Ductal AdenocarcinomaYoko Shimada, Takashi Kohno, Hideki Ueno, Yoshinori Ino, Hideyuki Hayashi, Takashi Nakaoku, Yasunari Sakamoto, Shunsuke Kondo, Chigusa Morizane, Kazuaki Shimada et al. · 2017 · The Oncologist
- Multi-Omics Analysis Based on Integrated Genomics, Epigenomics and Transcriptomics in Pancreatic CancerLingming Kong, Peng Liu, Mingjun Zheng, Busheng Xue, Keke Liang, Xiaodong Tan · 2020 · Epigenomics
- Characterization of pancreatic cancer with ultra-low tumor mutational burdenTaisuke Imamura, Ryo Ashida, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Keiichi Hatakeyama, Takeshi Nagashima et al. · 2023 · Scientific Reports
- Upregulated HOXA9 expression is associated with lymph node metastasis in colorectal cancerYohei Watanabe, Motonobu Saito, Katsuharu Saito, Yoshiko Matsumoto, Yasuyuki Kanke, Hisashi Onozawa, Suguru Hayase, Wataru Sakamoto, Teruhide Ishigame, Tomoyuki Momma et al. · 2017 · Oncology Letters
- Neoantigen-based immunotherapy in pancreatic ductal adenocarcinoma (PDAC)Hao Chen, Gang Yang, Jianchun Xiao, Lianfang Zheng, Lei You, Taiping Zhang · 2020 · Cancer Letters
- A Phase I Study of Ribociclib Plus Everolimus in Patients with Metastatic Pancreatic Adenocarcinoma Refractory to ChemotherapyBenjamin Adam Weinberg, Hongkun Wang, Agnieszka Katarzyna Witkiewicz, John Lindsay Marshall, Aiwu Ruth He, Paris J. Vail, Erik S. Knudsen, Michael Jon Pishvaian · 2020 · Journal of Pancreatic Cancer
- Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysisAlireza Tabibzadeh, Fahimeh Safarnezhad Tameshkel, Yousef Moradi, Saber Soltani, Maziar Moradi‐Lakeh, Gholam Hossein Ashrafi, Nima Motamed, Farhad Zamani, Seyed Abbas Motevalian, Mahshid Panahi et al. · 2020 · Scientific Reports