Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe +7 more·2015·Nature Communications

DOI 10.1038/ncomms7744

Cited by (1,000)

Items 201–300 of 1,000

Genome-wide association study of familial lung cancer
Jinyoung Byun, Ann G. Schwartz, Christine M. Lusk, Angela S. Wenzlaff, Mariza de Andrade, Diptasri M. Mandal, Colette Gaba, Ping Yang, Ming You, Elena Y. Kupert et al. · 2018 · Carcinogenesis
Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1
Yu Pan, Qinglin Fei, Ping Xiong, Jianyang Yang, Zheyang Zhang, Xianchao Lin, Minggui Pan, Fengchun Lu, Heguang Huang · 2019 · OncoImmunology
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing
Sara Parsa, Ana Ortega-Molina, Hsia‐Yuan Ying, Man Jiang, Matt R. Teater, Jiahui Wang, Chunying Zhao, Ed Reznik, Joyce P. Pasion, David C. Kuo et al. · 2020 · Nature Cancer
PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis
Daniela Basso, Elisa Gnatta, Andrea Padoan, Paola Fogar, Sara Furlanello, Ada Aita, Dania Bozzato, Carlo‐Federico Zambon, Giorgio Arrigoni, Chiara Frasson et al. · 2017 · Oncotarget
CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A
Tu, Q, Hao, J, Zhou, X, Yan, L, Dai, H, Sun, B, Yang, D, An, S, Lv, L, Jiao, B et al. · 2018 · Oncogene
Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer
Erik S. Knudsen, Vishnu Muthuraj Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam D. Grant, Paris J. Vail, Shailender Singh Chauhan, Tun Jie, Taylor Sohn Riall et al. · 2019 · Oncogene
A Prospective Feasibility Trial to Challenge Patient–Derived Pancreatic Cancer Organoids in Predicting Treatment Response
Alica K. Beutel, Lena Dorothee Schütte, Jeanette Scheible, Élodie Roger, Martin Müller, Lukas Perkhofer, Annika M. T. U. Kestler, Johann Michael Kraus, Hans Armin Kestler, Thomas F.E. Barth et al. · 2021 · Cancers
Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Australian Pancreatic Cancer Genome Initiative, Rae‐Anne Hardie, Ellen van Dam, Mark J. Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F. Shearer et al. · 2017 · Cancer & Metabolism
Molecular Events in the Natural History of Pancreatic Cancer
Leslie E. Oldfield, Ashton Anthony Connor, Steve Gallinger · 2017 · Trends in cancer
WNT Ligand Dependencies in Pancreatic Cancer
Kristina Y. Aguilera, David W. Dawson · 2021 · Frontiers in Cell and Developmental Biology
Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome
Natalia Anahi Juiz, Juan Iovanna, Nelson Dusetti · 2019 · Frontiers in Oncology
The molecular biology of peritoneal metastatic disease
Sanne Bootsma, Maarten F. Bijlsma, Louis Vermeulen · 2023 · EMBO Molecular Medicine
Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma
Luís Arnes, Zhaoqi Liu, Jiguang Wang, H. Carlo Maurer, Irina R. Sagalovskiy, Marta Sánchez-Martín, Nikhil K. Bommakanti, Diana C. Garofalo, Dina A. Balderes, Lori Sussel et al. · 2018 · Gut
A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer
Andreas Wolfgang Berger, Daniel Schwerdel, Anke Reinacher‐Schick, Waldemar H. Uhl, Hana Algül, Helmut Friess, Klaus‐Peter Janssen, Alexander Otto König, Michael B. Ghadimi, Eike Gallmeier et al. · 2019 · Theranostics
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Natalya Beglyarova, Eugenia Banina, Yan Zhou, Ramilia Mukhamadeeva, Grigorii V. Andrianov, Egor Bobrov, Elena Lysenko, Natalya Skobeleva, Linara Gabitova, Diana Restifo et al. · 2016 · Clinical Cancer Research
A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules
Margaret Elena Gatti-Mays, Julius Strauss, Renee Nicole Donahue, Claudia Palena, Jaydira Del Rivero, Jason Mark Redman, Ravi Amrit Madan, Jennifer L. Marté, Lisa M. Cordes, Elizabeth Lamping et al. · 2019 · Clinical Cancer Research
The activating transcription factor 2: an influencer of cancer progression
K Huebner, Jan Procházka, Ana Carolina Monteiro, Vijayalakshmi Mahadevan, Regine Schneider‐Stock · 2019 · Mutagenesis
Liquid biopsy in pancreatic cancer: the beginning of a new era
Dipesh Kumar Yadav, Xueli Bai, Rajesh Kumar Yadav, Alina Singh, Guogang Li, Tao Ma, Wei Chen, Tingbo Liang · 2018 · Oncotarget
Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies
Thao N. D. Pham, M. Shields, Christina Spaulding, D. Principe, Bo Li, Patrick W. Underwood, J. Trevino, D. Bentrem, H. Munshi · 2021 · Cancers
Loss of Rnf43 accelerates kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma
Hosein, Abdel Nasser, Dangol, Gita, Okumura, Takashi, Roszik, Jason, Rajapakshe, Kimal, Siemann, Megan, Zaid, Mohamed, Ghosh, Bidyut, Monberg, Maria, Guerrero, Paola A. et al. · 2022 · Gastroenterology
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities
Aditi Jain, Vikas Bhardwaj · 2021 · World Journal of Gastroenterology
RNA-binding proteins: Underestimated contributors in tumorigenesis
Yubo Zhao, Cristina Mir, Yoelsis Garcia‐Mayea, Rosanna Paciucci, Hiroshi Kondoh, Matilde Esther LLeonart · 2022 · Seminars in Cancer Biology
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Katelyn L. Donahue, Hannah R. Watkoske, Padma Kadiyala, Wenting Du, Kristee L. Brown, Michael K. Scales, Ahmed M. Elhossiny, Carlos E. Espinoza, Emily L. Lasse Opsahl, Brian D. Griffith et al. · 2024 · Cancer Discovery
Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61
M. Sano, David R. Driscoll, Wilfredo E. DeJesus-Monge, B. Quattrochi, Victoria A. Appleman, Jianhong Ou, L. J. Zhu, N. Yoshida, S. Yamazaki, Tadatoshi Takayama et al. · 2016 · Neoplasia
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts
Ines Lohse, Jacqueline M. Mason, Pinjiang Mary Cao, Melania Pintilie, Mark Robert Bray, David William Hedley · 2016 · Oncotarget
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
Yue Sun, Yufang Bao, Wenjian Han, Fan Song, Xianfeng Shen, Jiawei Zhao, Ji Zuo, David W. Saffen, Wei Chen, Zefeng Wang et al. · 2017 · Nucleic Acids Research
High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma
Maria Cristina Curia, Fabiana Fantini, Rossano Lattanzio, Francesca Tavano, Francesco Di Mola, Mauro Piantelli, Pasquale Battista, Pierluigi Di Sebastiano, Alessandro Cama · 2019 · BMC Cancer
RBM10: Structure, functions, and associated diseases
Akira Inoue · 2021 · Gene
The Extracellular Niche and Tumor Microenvironment Enhance KRAS Inhibitor Efficacy in Pancreatic Cancer
Vishnu Muthuraj Kumarasamy, Costakis G. Frangou, Jianxin Wang, Yin Wan, Andrew Dynka, Hanna R. Rosenheck, Prasenjit Dey, Ethan V. Abel, Erik S. Knudsen, Agnieszka Katarzyna Witkiewicz · 2024 · Cancer Research
KRAS: the Achilles’ heel of pancreas cancer biology
Kristina Drizyte‐Miller, Taiwo Talabi, Ashwin Somasundaram, Adrienne D. Cox, Channing J. Der · 2025 · Journal of Clinical Investigation
Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics
Liang Wang, Zhiliang Jia, Dacheng Xie, Tiansuo Zhao, Zhi Tan, Shuxing Zhang, Fanyang Kong, Daoyan Wei, Keping Xie · 2020 · Cancer Research
Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy
Marie-Ève Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor R. Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight et al. · 2022 · Nature Communications
Xp11 Translocation Renal Cell Carcinomas (RCCs) With RBM10-TFE3 Gene Fusion Demonstrating Melanotic Features and Overlapping Morphology With t(6;11) RCC
Qiuyuan Xia, Xiaotong Wang, Xuemei Zhan, Xiao Tan, Hao Chen, Yi Liu, Shanshan Shi, Xuan Wang, Xue Wei, Shengbing Ye et al. · 2017 · The American Journal of Surgical Pathology
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer
Else Driehuis, Hans C. Clevers · 2017 · British Journal of Pharmacology
Epiregulin as a therapeutic target in non-small-cell lung cancer
Noriaki Sunaga, Kyoichi Kaira · 2015 · Lung Cancer Targets and Therapy
Progress in Animal Models of Pancreatic Ductal Adenocarcinoma
Kaiwen Kong, Meng Guo, Yanfang Liu, Jianming Zheng · 2020 · Journal of Cancer
Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes
Do Young Hyeon, Dowoon Nam, Youngmin Han, Duk Ki Kim, Gibeom Kim, Daeun Kim, Jingi Bae, Seunghoon Back, Dong‐Gi Mun, Inamul Hasan Madar et al. · 2022 · Nature Cancer
Genomic signatures of pancreatic adenosquamous carcinoma (PASC)
Yuan Fang, Zhe Su, Jing Xie, Ruidong Xue, Qi Ma, Yanmeng Li, Yifan Zhao, Zeshi Song, Xiongxiong Lu, Hongwei Li et al. · 2017 · The Journal of Pathology
The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer
Rosalba Florio, Serena Veschi, Viviana di Giacomo, Sara Pagotto, Simone Carradori, Fabio Verginelli, Roberto Cirilli, Adriano Casulli, Antonino Grassadonia, Nicola Tinari et al. · 2019 · Cancers
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition
Jia Yu, Permeen A. Mohamed Yusoff, Daniëlle T.J. Woutersen, Pamela Goh, Nathan Harmston, Ron Smits, David Mark Epstein, David M. Virshup, Babita Madan · 2020 · Cancer Research
New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis
Matthäus Felsenstein, Ralph H. Hruban, Laura DeLong Wood · 2017 · Advances in Anatomic Pathology
A genetic roadmap of pancreatic cancer: still evolving
Faiyaz Notta, Stephan A. Hahn, Francisco X. Real · 2017 · Gut
Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy
Ashleigh Parkin, Jennifer Man, Paul Timpson, Marina Pajic · 2019 · FEBS Journal
Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma
Chen‐Song Huang, Xinru You, Chunlei Dai, Qiong‐Cong Xu, Fuxi Li, Li Wang, Xi‐Tai Huang, Jie‐Qin Wang, Shi‐Jin Li, Zhuoxing Gao et al. · 2020 · Advanced Science
PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
Jason Robert Pitarresi, Robert J. Norgard, Anna M. Chiarella, Kensuke Suzuki, Basil S. Bakir, Varun Sahu, Jinyang Li, Jun Zhao, Benoît Marchand, Maximilian D. Wengyn et al. · 2021 · Cancer Discovery
Arid1a restrains Kras-dependent changes in acinar cell identity
Livshits, Geulah, Alonso-Curbelo, Direna, Morris, John P, Koche, Richard, Saborowski, Michael, Wilkinson, John Erby, Lowe, Scott W · 2018 · eLife
Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches
İbrahim Halil Şahin, Maeve Aine Lowery, Zsofia Kinga Stadler, Erin E. Salo‐Mullen, Christine A. Iacobuzio–Donahue, David Paul Kelsen, Eileen Mary O'Reilly · 2016 · Expert Review of Gastroenterology & Hepatology
Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma
Qi Wu, Ying Tian, Jingqiu Zhang, Hongpeng Zhang, Fengming Gu, Yongdie Lu, Shengnan Zou, Yuji Chen, Pengxiang Sun, Mengyue Xu et al. · 2017 · Oncotarget
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery
Iwao Ojima, Xin Wang, Yunrong Jing, Changwei Wang · 2018 · Journal of Natural Products
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
Dongfeng Qu, Nathaniel Weygant, Jiannan Yao, Parthasarathy Chandrakesan, William L. Berry, Randal J. May, Kamille Pitts, Sanam Husain, Stan A. Lightfoot, Min Li et al. · 2019 · Journal of Oncology
SETDB1 Inhibits p53-Mediated Apoptosis and is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.
S. Ogawa, A. Fukuda, Y. Matsumoto, Yuta Hanyu, M. Sono, Yuichi Fukunaga, Tomonori Masuda, O. Araki, M. Nagao, Takaaki Yoshikawa et al. · 2020 · Gastroenterology
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Li Yan, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang et al. · 2022 · Journal of Hematology & Oncology
Combination Therapies and Drug Delivery Platforms in Combating Pancreatic Cancer
Lei, Fan, Xi, Xinyuan, Batra, Surinder K., Bronich, Tatiana K. · 2019 · The Journal of Pharmacology and Experimental Therapeutics
Genomics of adult and pediatric solid tumors.
Zahraa Rahal, Farah Abdulhai, Humam N. Kadara, Raya Hamad Saab · 2018 · Europe PMC (PubMed Central)
Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer
Xiaoming Ouyang, Yu Liu, Yang Zhou, Jing Guo, Tzu-Tang Wei, Chun Liu, Bomi Lee, Binbin Chen, Angela Zhang, Kerriann M. Casey et al. · 2021 · Stem Cell Reports
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Gebregiworgis, Teklab, Kano, Yoshihito, St-Germain, Jonathan, Radulovich, Nikolina, Udaskin, Molly L., Mentes, Ahmet, Huang, Richard, Poon, Betty P. K., He, Wenguang, Valencia-Sama, Ivette et al. · 2021 · Nature Communications
Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Jiajia Zhang, Christopher Lee Wolfgang, Lei Zheng · 2018 · Cancers
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers
Shan Li, Marla Lavrijsen, Aron Bakker, Marcin Magierowski, Katarzyna Magierowska, Pengyu Liu, Wenhui Wang, Maikel Petrus Peppelenbosch, Ron Smits · 2020 · Oncogene
Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer
Morten Lapin, Karin Hestnes Edland, Kjersti Tjensvoll, Satu Oltedal, Marie Austdal, Herish Garresori, Yves Rozenholc, Bjørnar Gilje, Oddmund Nordgård · 2023 · Clinical Cancer Research
Targeting KRAS mutations in pancreatic cancer: opportunities for future strategies
Anna Linehan, Mary O’Reilly, Ray McDermott, Grainne Mary O'Kane · 2024 · Frontiers in Medicine
INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division
Graeme J. Gowans, Alicia N. Schep, Ka Man Wong, Devin A. King, William James Greenleaf, Ashby J. Morrison · 2018 · Cell Reports
The roles of ubiquitin modifying enzymes in neoplastic disease
Nishi Kumari, Patrick William Jaynes, Azad Saei, Prasanna Vasudevan Iyengar, John Lalith Charles Richard, Pieter J.A. Eichhorn · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review
Anjali V. Sheahan, Andrew Victor Biankin, Christopher Richard Parish, Levon Michael Khachigian · 2018 · Oncotarget
Epithelial-Stromal Interactions in Pancreatic Cancer
Yaqing Zhang, Howard C. Crawford, Marina Pasca di Magliano · 2018 · Annual Review of Physiology
Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A., Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an et al. · 2021 · Cancer Research
RBM10 Regulates Tumor Apoptosis, Proliferation, and Metastasis
Yingshu Cao, Xin Di, Qinghua Zhang, Ranwei Li, Ke Wang · 2021 · Frontiers in Oncology
Targeted deep sequencing of circulating tumor DNA in metastatic pancreatic cancer
Andreas Wolfgang Berger, Daniel Schwerdel, Thomas Jens Ettrich, Alexander Hann, Stefan Andreas Schmidt, Alexander Kleger, Ralf B. Marienfeld, Thomas Theodor Werner Seufferlein · 2017 · Oncotarget
Genetically Engineered Pigs to Study Cancer
Daniela Kalla, Alexander Kind, Angelika Schnieke · 2020 · International Journal of Molecular Sciences
Exosomes: Potential for Early Detection in Pancreatic Cancer
Lingeng Lu, Harvey A. Risch · 2016 · Future Oncology
NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
Derya Kabacaoğlu, Dietrich Alexander Ruess, Jiaoyu Ai, Hana Algül · 2019 · Cancers
Pancreatic Ductal Adenocarcinoma (PDAC) Organoids: The Shining Light at the End of the Tunnel for Drug Response Prediction and Personalized Medicine
Pierre‐Olivier Frappart, Thomas G. Hofmann · 2020 · Cancers
Phase II study of selumetinib, an orally active inhibitor of MEK1 and MEK2 kinases, in KRASG12R-mutant pancreatic ductal adenocarcinoma
Cara M. Kenney, Tricia F. Kunst, Santhana Webb, Christina DeVisser, Christy Arrowood, Seth M. Steinberg, Niharika B. Mettu, Edward Jae-Hoon Kim, Udo Rudloff · 2021 · Investigational New Drugs
Functional and biological heterogeneity of KRAS Q61 mutations
Minh V. Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin et al. · 2022 · Science Signaling
Next-generation therapies for pancreatic cancer
Conor W. Buckley, Eileen Mary O'Reilly · 2024 · Expert Review of Gastroenterology & Hepatology
Molecular drivers and cells of origin in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine carcinoma
He-Li Gao, Wenquan Wang, Xianjun Yu, Liang Liu · 2020 · Experimental Hematology and Oncology
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization
Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Lei Wang et al. · 2021 · Cell Reports
Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer
Walaa E. Kattan, Junchen Liu, Dina Montufar‐Solis, Liang Hong, Bhargavi Brahmendra Barathi, Ransome van der Hoeven, Yong Zhou, John F. Hancock · 2021 · Proceedings of the National Academy of Sciences
RBM10: Harmful or helpful‐many factors to consider
Julie J. Loiselle, Leslie C. Sutherland · 2017 · Journal of Cellular Biochemistry
Next-Generation Sequencing in Pancreatic Cancer
Gong-Qing Shen, Essa M. Aleassa, Richard Matthew Walsh, Gareth J Morris‐Stiff · 2019 · Pancreas
Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets
Yongbo Wang, Yufang Bao, Sirui Zhang, Zefeng Wang · 2020 · Science China Life Sciences
A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer
Keiko Shinjo, Kazuo Hara, Genta Nagae, Takayoshi Umeda, Keisuke Katsushima, Miho M. Suzuki, Yoshiteru Murofushi, Yuta Umezu, Ichiro Takeuchi, Satoru Takahashi et al. · 2020 · PLoS ONE
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Benoît Thibault, Fernanda Ramos‐Delgado, Elvire Pons Tostivint, Nicole Therville, Célia Cintas, Silvia Arcucci, Stéphanie Cassant‐Sourdy, Gabriela Reyes‐Castellanos, Marie Tosolini, Amélie V. Villard et al. · 2021 · EMBO Molecular Medicine
Subtyping Pancreatic Cancer
Andrew Victor Biankin, Anirban Maitra · 2015 · Cancer Cell
A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas
Nebojša Skorupan, Mehwish Iqra Ahmad, Seth M. Steinberg, Jane B. Trepel, Derek Cridebring, Haiyong Han, Daniel D. Von Hoff, Christine Alewine · 2022 · Future Oncology
High‐grade Pan<scp>IN</scp> presenting with localised stricture of the main pancreatic duct: A clinicopathological and molecular study of 10 cases suggests a clue for the early detection of pancreatic cancer
Yokode, Masataka, Akita, Masayuki, Fujikura, Kohei, Kim, Mi‐Ju, Morinaga, Yukiko, Yoshikawa, Seiichi, Terada, Takuro, Matsukiyo, Hiroshi, Tajiri, Takuma, Abe‐Suzuki, Shiho et al. · 2018 · Histopathology
Tumor mutational burden analysis of 2,000 Japanese cancer genomes using whole exome and targeted gene panel sequencing
Keiichi Hatakeyama, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Masakuni Serizawa, Sumiko Ohnami, Yuji Shimoda, Shumpei Ohnami, Koji Maruyama, Akane Naruoka et al. · 2018 · Biomedical Research
Integrative Analysis of Novel Metabolic Subtypes in Pancreatic Cancer Fosters New Prognostic Biomarkers
Laura Follia, Giulio Ferrero, Giorgia Mandili, Marco Beccuti, Daniele Giordano, Rosella Spadi, Maria Antonietta Satolli, Andrea Evangelista, Hiroyuki Katayama, Wang Hong et al. · 2019 · Frontiers in Oncology
The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer
Nesrin M. Hasan, Nita Ahuja · 2019 · Cancers
Human CtIP: A ‘double agent’ in DNA repair and tumorigenesis
Nour L. Mozaffari, Fabio Pagliarulo, Alessandro A. Sartori · 2020 · Seminars in Cell and Developmental Biology
Cellular and molecular aspects of pancreatic cancer
Armen Gharibi, Yvess Adamian, Jonathan A. Kelber · 2016 · Acta Histochemica
Role of RNF20 in cancer development and progression – a comprehensive review
Gautam Sethi, Muthu Kumaraswamy Shanmugam, Frank Arfuso, Alan Prem Kumar · 2018 · Bioscience Reports
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda et al. · 2018 · Nature Communications
Advances in oncolytic adenovirus therapy for pancreatic cancer
Callum Baird Nattress, Gunnel Halldén · 2018 · Cancer Letters
10-Plex Digital Polymerase Chain Reaction with Four-Color Melting Curve Analysis for Simultaneous KRAS and BRAF Genotyping
Tatsuo Nakagawa, Junko Tanaka, Kunio Harada, Akiko Shiratori, Yuzuru Shimazaki, Takahide Yokoi, Chihiro Uematsu, Yoshinobu Kohara · 2020 · Analytical Chemistry
Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma
Siddhartha Yadav, Pashtoon Murtaza Kasi, William R. Bamlet, Thanh P. Ho, Eric C. Polley, Chunling Hu, Steven N. Hart, Kari G. Rabe, Nicholas James Boddicker, Rohan David Gnanaolivu et al. · 2020 · Clinical Cancer Research
Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights
Léo Mas, Renato Micelli Lupinacci, Jerome F. Cros, Jean‐Baptiste Bachet, Florence Coulet, Magali Svrcek · 2021 · International Journal of Molecular Sciences
Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes
Kelly E. Craven, Jesse Gore, Julie L. Wilson, Murray Korc · 2015 · Oncotarget
Inhibition of PI3K/AKT Signaling Pathway Radiosensitizes Pancreatic Cancer Cells with ARID1A Deficiency in Vitro
Lin Yang, Guanghai Yang, Yingjun Ding, Yuhong Dai, Sanpeng Xu, Qiuyun Guo, Aini Xie, Guangyuan Hu · 2018 · Journal of Cancer
A Novel Multiplex Droplet Digital PCR Assay to Identify and Quantify KRAS Mutations in Clinical Specimens
Miguel Alcaide, Matthew C. Cheung, Kevin R. Bushell, Sarah E. Arthur, Hui‐Li Wong, Joanna M. Karasinska, Daniel John Renouf, David F. Schaeffer, Suzan McNamara, Mathilde Couëtoux du Tertre et al. · 2018 · Journal of Molecular Diagnostics
Precision medicine in pancreatic cancer: treating every patient as an exception
Brian T. Herbst, Lei Zheng · 2019 · The Lancet. Gastroenterology & hepatology