A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism
Krarup, Anders, Truan, Daphné, Furmanova-Hollenstein, Polina, Bogaert, Lies, Bouchier, Pascale, Bisschop, Ilona J. M., Widjojoatmodjo, Myra N., Zahn, Roland +3 more·2015·Nature Communications
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- Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and RabbitsJun Yu Zhou, Christopher Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily A. Gomme, Rani S. Sellers, Cynthia M. Rohde · 2024 · Vaccines
- Computational discovery of RSV Pre-F inhibitors via reinforcement learning-driven ab initio design from natural fragment librariesShengpeng Wang, Yongzhu Zhao, Jiawei Li, Lifu Zhang, Fei Yan, Cuihong Wang, Liying Shi, Meiling Zhang, Meiling Zhang · 2025 · Computational Biology and Chemistry
- Virus-like particles containing the extracellular domain of G protein in combination with a CTL peptide of M2 elicit protection against respiratory syncytial virus infection without pulmonary diseaseHuan Qin, Jin Luo, Zishu Pan · 2025 · Frontiers in Immunology
- Age-specific antibody profiles of respiratory syncytial virus after COVID-19 pandemic: a sero-epidemiological survey in Taizhou City, Eastern ChinaBo Zheng, Qiang Wang, Kathy S. M. Leung, Hongbiao Liang, Weiwei Shen, Mengting Cao, Suyi Zhang, Ye Wu, Haijiang Lin, Weibing Wang · 2025 · BMC Infectious Diseases
- Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilitiesPreeti Moar, Christoffer Granvik, Kim Balaton Blom, Erick Bermúdez-Méndez, Florian A. Gegenfurtner, Julia Wigren Byström, Peter Fjällström, Mikael Åberg, Johan Normark, Karin Loré et al. · 2026 · BMC Medicine
- Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutationSophie R. Shoemaker, Megan Luo, Kim-Marie A. Dam, John E. Pak, Magnus A. G. Hoffmann, Susan Marqusee · 2026 · Science Advances
- AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen designJelle M. Melchers, Jarek Juraszek, Ruben J. G. Hulswit, Daan van Overveld, Lam Le, Frank J. M. van Kuppeveld, Daniel L. Hurdiss, Berend‐Jan Bosch, Johannes P.M. Langedijk, Mark J. G. Bakkers · 2026 · PLoS Pathogens
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- Mammalian Antigen Display for Pandemic CountermeasuresAndrea Quezada, Ankur Annapareddy, Kamyab Javanmardi, John Cooper, Ilya J. Finkelstein · 2024 · Methods in molecular biology
- A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine modelJérémy Brunet, Zaineb Choucha, Marion Gransagne, Houda Tabbal, Min‐Wen Ku, Julian Buchrieser, Priyanka Fernandes, Damien Batalie, Jodie Lopez, Laurence Ma et al. · 2024 · Journal of Virology
- Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virusSergey A. Klotchenko, Ekaterina Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia Pulkina, Aram A. Shaldzhyan, Балабашин Дмитрий Сергеевич, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov · 2024 · Journal of microbiology epidemiology immunobiology
- mRNA疗法的研究进展与挑战Jiayan Fu, Shuo Feng, Binhe Du, Haiyang Dong, Jinzhong Lin, Jin Yongfeng · 2021 · Scientia Sinica Vitae
- Respiratory Syncytial VirusJosé Antonio Melero, Alfonsina Trento, Vicente Más · 2017 · Encyclopedia of Life Sciences
- Efficacy and safety of an mRNA-based RSV preF vaccine in preclinical studiesHuarong Bai, Qin Li, Yue Gao, yubin zhao, xueliang yu, Rongkuan Hu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Evaluation of Viral Diagnostics on rEspiratory iNfections in ChildrEnJérôme O. Wishaupt · 2012
- Respiratory Syncytial Virus Fusion Protein Interaction with its Cellular Receptor, NucleolinDaniel Zhu · 2018 · TSpace (University of Toronto)
- Magnitude of RSV Fusion Protein-Specific Antibodies in Infants and Corresponding MothersSara Taleb · 2018 · Qatar University QSpace (Qatar University)
- CHARACTERIZATION AND IMMUNOMODULATION OF THE INFANT IMMUNE RESPONSE TO RESPIRATORY SYNCYTIAL VIRUSKatherine Km Eichinger · 2019 · D-Scholarship@Pitt (University of Pittsburgh)
- Alveolar-Like Stem Cell-Derived Macrophages Protect Against RSV Induced Lung DamageYuchen Cen · 2020 · TSpace (University of Toronto)
- Faculty Opinions recommendation of Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus.Shama Parveen · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of A safe and efficient BCG vectored vaccine to prevent the disease caused by the human Respiratory Syncytial Virus.Fernando P. Polack · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.Mark Marsh · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus.Rino Rappuoli · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Pre-fusion F is absent on the surface of formalin-inactivated respiratory syncytial virus.Fernando P. Polack · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- ANTI-VIRUS ACTION OF MEDICINAL PLANTS (LITERATURE REVIEW)Nadiia GORCHAKOVA, Yulia GUSEVA, Tatyana HARNYK, Stanislav VESELSKY, A. M. Doroshenko, Ella GOROVA · 2022 · Fìtoterapìâ
- A Poorest-First Approach to RSV Vaccine DevelopmentNatalie I Mazur · 2022
- Caught in the Act: targeted mutagenesis of the herpesvirus fusogen central helix captures transition statesMomei Zhou, Benjamin Vollmer, Emily A. Machala, Muyuan Chen, Kay Grünewald, Ann M. Arvin, Wah Chiu, Stefan L. Oliver · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- We are all on the same teamAnnefleur C. Langedijk · 2023
- Pneumonia A Review based on Pathogenic FactorsCheng Lin, Baibai Ye, Ping Chen, Linfu Li · 2023 · Current Traditional Medicine
- Generation of novel respiratory syncytial virus vaccine candidate antigens that can induce high levels of prefusion-specific antibodiesRima Matsuyama, Tomoharu Hogiri, Hiroyuki Kishida, Kei Takedomi, Okimasa Okada, Akitoshi Nishizawa, Sakiko Higashi-Nakatani, Takeshi Ōmasa · 2024 · Journal of Bioscience and Bioengineering
- From nutritional support to innovative vaccines: Approaches to bolster the immune response to respiratory infectionSuyeon Hong · 2024
- KD-409, a Respiratory Syncytial Virus FG Chimeric Protein without the CX3C Chemokine Motif, Is an Efficient Respiratory Syncytial Virus Vaccine Preparation for Passive and Active Immunization in MiceRyo Yamaue, Masaharu Torikai, Madoka Terashima, Hiroaki Mori · 2024 · Vaccines
- Immune Response to Respiratory Syncytial VirusHujaz Ismail Abdulrazzaq Alqirbi, Batool Mutar Mahdi, Mustafa Almukhtar · 2024 · Iraqi Journal of Community Medicine
- A Single Amino Acid Mutation Alters the Neutralization Epitopes in the Respiratory Syncytial Virus Fusion GlycoproteinAhmed K. Oraby, Aleksandra Stojic, Farah Elawar, Leanne M. Bilawchuk, Ryley D. McClelland, Kaci Erwin, Madison J. Granoski, Cameron D. Griffiths, Justin D. Frederick, Elena I Arutyunova et al. · 2024 · Research Square
- Research progress on the structure of Epstein-Barr virusLing ZHONG, YuFei WANG, Chengyu Yang, Yang Huang, Huiping He, Qingbing Zheng, Xiao ZHANG · 2024 · Scientia Sinica Vitae
- Development of a genetically modified full-length human respiratory syncytial virus preF protein vaccineGeqi Lao, Jin Feng, Liping Wu, Wenhan Su, Liyun Chen, Lejun Yang, Songchen Zhang, Yuhua Xu, Tao Peng · 2025 · Vaccine
- A bivalent mRNA vaccine against RSV infection in rodent modelsJuan Liu, Hanqing Zhao, Wenhao Wang, Bin Yang, Naifang Zhang, Yu Zhang, Jie Qian, Qiaofang Ma, Yankun Lu, Huafeng Han et al. · 2025 · Frontiers in Immunology
- Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibodyAmin Addetia, Lisa Perruzza, Young‐Jun Park, Matthew McCallum, Cameron Stewart, Jack T Brown, Alessia Donati, Katja Culap, Alessio Balmelli, Michal Gaži et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Stabilizing the Shield: C-Terminal Tail Mutation of HMPV F Protein for Enhanced Vaccine DesignReetesh Kumar, Subhomoi Borkotoky, Rohan Gupta, Jyoti Gupta, Somnath Maji, Savitri Tiwari, Rajeev Kumar Tyagi, Baldomero Oliva · 2025 · BioMedInformatics
- Stabilization of the trimeric pre-fusion structures of influenza H1 and H9 hemagglutinins by mutations in the stem helicesGa Young Lee, Yun Geun Kim, Shin Hc, Chang Jun Lee, Jie‐Oh Lee · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Comparative Evaluation of Three Nanoparticle Vaccines Targeting the Prefusion F Protein of Respiratory Syncytial Virus: Immunogenicity and Protective Efficacy.Jie Jiang, Hongqiao Hu, Lei Cao, Naiying Mao, Zhen Zhu, Na Wang, Yuqing Shi, Li Hai, Yan Zhang · 2025 · PubMed Central
- Engineering mucosal immunity: Advanced vaccine platforms against respiratory pathogensMusi Wang, Qi Chang, Bowen Li, Run Yang, Xuheng Chen, Yang Bai, Huining He, Bin Zheng · 2025 · Precision medicine and engineering.
- Molecular Mechanisms of Respiratory Syncytial Virus PathogenesisMadison J. Granoski, Aleksandra Stojic, Stephen Z. Lee, David Marchant · 2025 · Annual Review of Pathology Mechanisms of Disease
- Additional file 1 of Efficacy, immunogenicity and safety of respiratory syncytial virus prefusion F vaccine: systematic review and meta-analysisPang, Yi, Lu, Haishan, Demin Cao, Xiaoying Zhu, Qinqin Long, Fengqin Tian, Long, Xidai, Li, Yulei · 2024 · Figshare
- Respiratory Syncytial Virus F Protein Adjuvanted with a Carbomer-Based Adjuvant Induces Protective Humoral Response in MiceShivam Kumar Singh, Balwant Singh, Bhisma Narayan Panda, Thomas Cleven, Marulasiddappa R Suresh, Guruprasad R. Medigeshi · 2026 · ACS Omega
- Adenovector 26 Encoded RSV Prefusion F Protein (Ad26.RSV.preF) Does Not Predispose to Enhanced Respiratory Disease in Preclinical Rodent ModelsRenske Bolder, Susan B. S. King, Roland C. Zahn, Leslie van der Fits · 2026 · Vaccines
- An Integrative Biophysical Framework for Quantifying Conformational Dynamics in Complex Biomolecular Systems: Perspectives on Viral Glycoprotein Evolutionary DivergenceSami Rashid Mohammed Shibah · 2026 · SSRN Electronic Journal
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- Optimally fixed F protein on the surface of RSV-infected cells for RSV binding and neutralizing assaysHongsheng Qiang, Yujin Shi, Zemin Jiang, Yuhao Fu, Xiaobin Zhang, Li Chen, Yongpeng Sun, Yangling Wu, Zizheng Zheng, Ningshao Xia · 2026 · Frontiers in Microbiology
- Innovative antiviral strategies: Clinical advances in respiratory syncytial virus inhibitor developmentSundian Liu, Jinrong Hu, Kairui Kang, Meiyan Wei, Xintao Deng, Han Li, Zhiyou Yang · 2026 · Elsevier eBooks
- Structural vaccinology expedites rational design of next-generation vaccines for influenza and respiratory syncytial virusLei Deng, Jiaye Liu, Yu Peng · 2026 · Virologica Sinica
- Étude de l'infection par le métapneumovirus humain : facteurs de virulence et développement de vaccins vivants atténuésJulia Dubois · 2018
- Structural vaccinology applied to HantavirusesAlexandra Serris · 2020
- Conception de médicaments contre le virus de la bronchiolite à partir d'une nouvelle cible thérapeutiqueSilva Khodjoyan · 2023 · theses.fr (ABES)
- Genomic surveillance in the UAE reveals the global origins and local diversification of RSV lineagesHao Zhou, Salwa Ali, Madikay Senghore, Amirtharaj Francis, Pamela Murad, Mahra Al Hosani, Faisal Al Ahbabi, Andreas Henschel, Farida Ismail Al Hosani, Dean Everett · 2026 · Research Square
- A fusion protein’s weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion proteinMaximilian Crosby, Ariel J. Kuhn, Gillian Zipursky, Tara C. Marcink, Kyle N. Stearns, Elizabeth B. Sobolik, Dariia Vyshenska, Jee Ching Mook, Alexander L. Greninger, Matteo Porotto et al. · 2026 · mBio
- Novel Vaccine DevelopmentTatsuo Shioda · 2026 · Springer eBooks
- Enhanced Th1 Cellular Immunity Induced by an RSV-F mRNA Vaccine Rationally Designed Using NLP AlgorithmsZhi-Wu Xia, Qi Tang, Jun-Jie Pan, Jing Liu, Lan-Xin Jia, Guo-Mei Zhang, Man-Ni Xie, Jia-Hao Zheng, Chuan-Shuo Lv, Lei Zhang et al. · 2026 · Vaccines
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- A novel prefusion and trimer-stabilized RSV F vaccine with robust immunogenicity and protection against respiratory syncytial virusXinghua Che · 2026 · Research Square
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- A cavity-reduced prefusion RSV F bivalent vaccine elicits durable and protective immunityLijie Liu, Mengrong Yan, Ruoxu Liang, Qingxin Wu, Changbin Qu, Huiqi Wu, Zhi Liao, Huiyu Chen, Jingjing Zou, Zeyun Sun et al. · 2026 · EMBO Molecular Medicine
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