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Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
Abstract
Abdominal fat accumulation has been shown to play crucial roles in the development of metabolic syndrome. Visceral fat accumulation particularly is closely correlated to the development of cardiovascular disease and obesity-related disorders such as diabetes mellitus, hyperlipidemia and hypertension. Given these clinical findings, the functions of adipocytes have been intensively investigated in the past 10 years, and have been revealed to act as endocrine cells that secrete various bioactive substances termed adipocytokines. Among adipocytokines, tumor-necrosis factor-alpha, plasminogen activator inhibitor type 1 and heparin-binding epidermal growth factor-like growth factor are produced in adipocytes as well as other organs, and contribute to the development of vascular diseases. Visfatin has been identified as a visceral-fat-specific protein that might be involved in the development of obesity-related diseases, such as diabetes mellitus and cardiovascular disease. In contrast to these adipocytokines, adiponectin, which is an adipose-tissue-specific, collagen-like protein, has been noted as an important antiatherogenic and antidiabetic protein, or as an anti-inflammatory protein. The functions of adipocytokine secretion might be regulated dynamically by nutritional state. Visceral fat accumulation causes dysregulation of adipocyte functions, including oversecretion of tumor-necrosis factor-alpha, plasminogen activator inhibitor type 1 and heparin-binding epidermal growth factor-like growth factor, and hyposecretion of adiponectin, which results in the development of a variety of metabolic and circulatory diseases. In this review, the importance of adipocytokines, particularly adiponectin, is discussed with respect to cardiovascular diseases.
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“Witham et al. (751) provided 100 000 IU (2500 mg) vitamin D 2 or placebo to elderly patients with systolic heart failure at study entry (week 0) and after 10 weeks and found no effect on plasma TNF-a at 10 or 20 weeks.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [751]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Self-citationRetractedRole of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Self-citationDeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Self-citationAdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Self-citationDiet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Self-citationMaeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081
Self-citationLarsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,782
Ouchi, N., Kihara, S., Arita, Y., Okamoto, Y., Maeda, K., Kuriyama, H., Hotta, K., Nishida, M., Takahashi, M., Muraguchi, M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.11.1296 · Cited by 1,730
Self-citationMaeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,673
Self-citationKaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,672
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000048856.22331.50 · Cited by 1,419
Self-citationThe Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H., et al. (2001) · Circulation · doi:10.1161/01.cir.103.8.1057 · Cited by 1,281
Self-citationFujioka, S., Matsuzawa, Y., Tokunaga, K., & Tarui, S. (1987) · Metabolism · doi:10.1016/0026-0495(87)90063-1 · Cited by 1,205
Self-citationAdiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203
Self-citationAdiponectin and development of type 2 diabetes in the Pima Indian population
Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094
Self-citationAdiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice
Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,036
Self-citationTomas, E., Tsao, T.-S., Saha, A. K., Murrey, H. E., Zhang, C. C., Itani, S. I., Lodish, H. F., & Ruderman, N. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222657499 · Cited by 973
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 889
Self-citationT-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T., & Lodish, H. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403382101 · Cited by 873
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390070054005 · Cited by 842
Role of Adiponectin in Preventing Vascular Stenosis
Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., Kumada, M., Okamoto, Y., Nagaretani, H., Nishizawa, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206083200 · Cited by 820
Self-citationZoccali, C., Mallamaci, F., Tripepi, G. L., Benedetto, F. A., Cutrupi, S., Parlongo, S., Malatino, L., Bonanno, G., Seminara, G., Rapisarda, F., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131134 · Cited by 756
Self-citationArita, Y., Kihara, S., Ouchi, N., Maeda, K., Kuriyama, H., Okamoto, Y., Kumada, M., Hotta, K., Nishida, M., Takahashi, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000018622.84402.ff · Cited by 698
Self-citationAdiponectin-mediated modulation of hypertrophic signals in the heart
Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671
Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin
Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K. X., Kumada, M., Abe, Y., Funahashi, T., & Matsuzawa, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000119921.86460.37 · Cited by 666
Self-citationHypoadiponectinemia Is an Independent Risk Factor for Hypertension
Iwashima, Y., Katsuya, T., Ishikawa, K., Ouchi, N., Ohishi, M., Sugimoto, K., Fu, Y., Motone, M., Yamamoto, K. I., Matsuo, A., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000129281.03801.4b · Cited by 609
Self-citationAssociation of Hypoadiponectinemia With Impaired Vasoreactivity
Ouchi, N., Ohishi, M., Kihara, S., Funahashi, T., Nakamura, T., Nagaretani, H., Kumada, M., Ohashi, K., Okamoto, Y., Nishizawa, H., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000083488.67550.b8 · Cited by 597
Self-citationAn Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls
Okamoto, Y., Arita, Y., Nishida, M., Muraguchi, M., Ouchi, N., Takahashi, M., Igura, T., Inui, Y., Kihara, S., Nakamura, T., et al. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978586 · Cited by 567
Self-citationStefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R. S., YOUNGREN, J. F., Havel, P. J., Pratley, R. E., Bogardus, C., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1884 · Cited by 557
Self-citationKumada, M., Kihara, S., Ouchi, N., Kobayashi, H., Okamoto, Y., Ohashi, K., Maeda, K., Nagaretani, H., Kishida, K., Maeda, N., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127953.98131.ed · Cited by 555
Self-citationDesprés, J., Nadeau, A., Tremblay, A., Ferland, M., Moorjani, S., Lupien, P. J., Thériault, G., Pinault, S., & Bouchard, C. (1989) · Diabetes · doi:10.2337/diab.38.3.304 · Cited by 475
Nakamura, T., Tokunaga, K., Shimomura, I., Nishida, M., Yoshida, S., Kotani, K., Islam, A. H. M. W., Keno, Y., Kobatake, T., Nagai, Y., et al. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90025-6 · Cited by 429
Self-citationAtherosclerotic Renal Artery Stenosis
Zoccali, C., Mallamaci, F., & Finocchiaro, P. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032548.18973.0f · Cited by 428
Association of Adiponectin Mutation With Type 2 Diabetes
Kondo, H., Shimomura, I., Matsukawa, Y., Kumada, M., Takahashi, M., Matsuda, M., Ouchi, N., Kihara, S., Kawamoto, T., Sumitsuji, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2325 · Cited by 386
Self-citationRole of Adipocytokines on the Pathogenesis of Atherosclerosis in Visceral Obesity.
Funahashi, T., Nakamura, T., Shimomura, I., Maeda, K., Kuriyama, H., Takahashi, M., ARITA, Y., Kihara, S., & Matsuzawa, Y. (1999) · Internal Medicine · doi:10.2169/internalmedicine.38.202 · Cited by 380
Self-citationSecretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose Tissue
Halleux, C. M., Takahashi, M. P., Delporte, M., Détry, R., Funahashi, T., Matsuzawa, Y., & Brichard, S. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5904 · Cited by 344
Self-citationAnalysis of an expression profile of genes in the human adipose tissue
Maeda, K., Okubo, K., Shimomura, I., Mizuno, K., Matsuzawa, Y., & Matsubara, K. (1997) · Gene · doi:10.1016/s0378-1119(96)00730-5 · Cited by 294
Self-citationClose correlation of intra-abdominal fat accumulation to hypertension in obese women.
Kanai, H., Matsuzawa, Y., Kotani, K., Keno, Y., Kobatake, T., Nagai, Y., Fujioka, S., Tokunaga, K., & Tarui, S. (1990) · Hypertension · doi:10.1161/01.hyp.16.5.484 · Cited by 267
Self-citationFisher, F., Trujillo, M. E., Hanif, W., Barnett, A. H., McTernan, P. G., Scherer, P. E., & Kumar, S. (2005) · Diabetologia · doi:10.1007/s00125-005-1758-7 · Cited by 264
Shinohara, E., Kihara, S., Yamashita, S., Yamane, M., Nishida, M., ARAI, T., Kotani, K., Nakamura, T., TAKEMURA, K., & Matsuzawa, Y. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.63889000.x · Cited by 253
Self-citationYamashita, S., Nakamura, T., Shimomura, L., Nishida, M., Yoshida, S., Kotani, K., Kameda-Takemuara, K., Tokunaga, K., & Matsuzawa, Y. (1996) · Diabetes Care · doi:10.2337/diacare.19.3.287 · Cited by 208
Self-citationEvans, D. J., Murray, R., & Kissebah, A. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111565 · Cited by 199
Hulthe, J., Hultén, L. M., & Fagerberg, B. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00313-5 · Cited by 153
Visceral Fat Accumulation and Its Relation to Plasma Hemostatic Factors in Healthy Men
CIGOLINI, M., Targher, G., Andreis, I. A. B., Tonoli, M., Agostino, G., & Sandre, G. D. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.3.368 · Cited by 141
Rao, G. (2012) · Springer eBooks · doi:10.1007/978-3-540-29807-6_4297 · Cited by 128
Correlation of intraabdominal fat accumulation and left ventricular performance in obesity
NAKAJIMA, T., Fujioka, S., Tokunaga, K., Matsuzawa, Y., & Tarui, S. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90537-7 · Cited by 114
Self-citationNishizawa, H., Yamagata, K., Shimomura, I., Takahashi, M., Kuriyama, H., Kishida, K., Hotta, K., Nagaretani, H., Maeda, N., Matsuda, M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104301200 · Cited by 103
Self-citationAdipocytokines and Metabolic Syndrome
Matsuzawa, Y. (2005) · Seminars in Vascular Medicine · doi:10.1055/s-2005-871744 · Cited by 95
Self-citationIncreased Plasma HB-EGF Associated with Obesity and Coronary Artery Disease
Matsumoto, S., Kishida, K., Shimomura, I., Maeda, N., Nagaretani, H., Matsuda, M., Nishizawa, H., Kihara, S., Funahashi, T., & Matsuzawa, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6720 · Cited by 87
Self-citationNakamura, T., Kobayashi, H., Yanagi, K., Nakagawa, T., Nishida, M., Kihara, S., Hiraoka, H., Nozaki, S., Funahashi, T., Yamashita, S., et al. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800445 · Cited by 35
Self-citationMatsuzawa, Y. (1997) · doi:10.1002/(sici)1099-0895(199703)13:1
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Metadata
- Authors
- Matsuzawa, Y.
- Venue
- Nature Clinical Practice Cardiovascular Medicine
- Published
- 2006-01
- Volume
- 3
- Issue
- 1
- Pages
- 35-42
- ISSN
- 1743-4297 (ISSN-L)
- 1743-4300
- OpenAlex
- W2060823593
- Cited by
- 434
- References
- 60
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 12 · 2019: 13 · 2018: 9 · 2017: 19 · 2016: 15 · 2015: 24 · 2014: 30 · 2013: 25 · 2012: 33
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipokines, metabolic syndrome, cardiovascular disease, adiponectin, TNF-α, plasminogen activator inhibitor-1, HB-EGF, visfatin, visceral fat, obesity, diabetes mellitus, atherosclerosis, anti-inflammatory activity
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Humans, Risk Factors, Cytokines, Metabolic Syndrome, Adiponectin
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