Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
Abstract
Background Many patients with coronary heart disease do not achieve recommended LDL-cholesterol levels, due to either intolerance or inadequate response to available lipid-lowering therapy. Microsomal triglyceride transfer protein (MTP) inhibitors might provide an alternative way to lower LDL-cholesterol levels. We tested the safety and LDL-cholesterol-lowering efficacy of an MTP inhibitor, AEGR-733 (Aegerion Pharmaceuticals Inc., Bridgewater, NJ), alone and in combination with ezetimibe.Methods We performed a multicenter, double-blind, 12-week trial, which included 84 patients with hypercholesterolemia. Patients were randomly assigned ezetimibe 10 mg daily (n = 29); AEGR-733 5.0 mg daily for the first 4 weeks, 7.5 mg daily for the second 4 weeks and 10 mg daily for the last 4 weeks (n = 28); or ezetimibe 10 mg daily and AEGR-733 administered with the dose titration described above (n = 28).Results Ezetimibe monotherapy led to a 20-22% decrease in LDL-cholesterol concentrations. AEGR-733 monotherapy led to a dose-dependent decrease in LDL-cholesterol concentration: 19% at 5.0 mg, 26% at 7.5 mg and 30% at 10 mg. Combined therapy produced similar but larger dose-dependent decreases (35%, 38% and 46%, respectively). The number of patients who discontinued study drugs owing to adverse events was five with ezetimibe alone, nine with AEGR-733 alone, and four with combined ezetimibe and AEGR-733. Discontinuations from AEGR-733 were due primarily to mild transaminase elevations.Conclusions Inhibition of LDL production with low-dose AEGR-733, either alone or in combination with ezetimibe, could be an effective therapeutic option for patients unable to reach target LDL-cholesterol levels.
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In a phase-3 study involving subjects with a high risk for cardiovascular events including those with heterozygous FH, administrating PCSK9 inhibitor once every two weeks decreased LDL-C levels by 70-75% with combination oral statins.
“In a phase-3 study involving subjects with a high risk for cardiovascular events including those with heterozygous FH, administrating PCSK9 inhibitor once every two weeks decreased LDL-C levels by 70–75% with combination oral statins682, 683).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [683]
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Self-citationExpert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Smith, S. C., Allen, J. K., Blair, S. N., Bonow, R. O., Brass, L. M., Fonarow, G. C., Grundy, S. M., Hiratzka, L. F., Jones, D. W., Krumholz, H. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.174516 · Cited by 2,088 · see citing works
Intensive Lifestyle Changes for Reversal of Coronary Heart Disease
Ornish, D. (1998) · JAMA · doi:10.1001/jama.280.23.2001 · Cited by 1,730 · see citing works
Svedlund, J., Sjödin, I., & Dotevall, G. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01535722 · Cited by 1,319 · see citing works
Stern, L., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, M., Gracely, E. J., & Samaha, F. F. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00007 · Cited by 831 · see citing works
Self-citationStem, L., Iqbal, N., Seshadri, P., & Chicano, K. L. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.07.103 · Cited by 629 · see citing works
Revicki, D. A., Wood, M., Wiklund, I. E., & Crawley, J. A. (1997) · Quality of Life Research · doi:10.1023/a:1008841022998 · Cited by 623 · see citing works
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580 · see citing works
Self-citationSharp, D., Blinderman, L., Combs, K. A., Kienzle, B. K., Ricci, B., Wager‐Smith, K., Gil, C. M., Turck, C. W., Boumas, M.-E., Rader, D. J., et al. (1993) · Nature · doi:10.1038/365065a0 · Cited by 501 · see citing works
Self-citationRisk for Myopathy With Statin Therapy in High-Risk Patients
Ballantyne, C. M., Corsini, A., Davidson, M. H., Holdaas, H., Jacobson, T. A., Leitersdorf, E., März, W., Reckless, J. P. D., & Stein, E. A. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.5.553 · Cited by 452 · see citing works
Knopp, R. H. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00807-2 · Cited by 401 · see citing works
Temel, R. E., Tang, W., Ma, Y., Rudel, L. L., Willingham, M. C., Ioannou, Y. A., Davies, J. P., Nilsson, L.-M., & Yu, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30060 · Cited by 368 · see citing works
An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits
Wetterau, J. R., Gregg, R. E., Harrity, T. W., ARBEENY, C. M., Cap, M., Connolly, F., Chu, C.-H., George, R. J., Gordon, D. A., Jamil, H., et al. (1998) · Science · doi:10.1126/science.282.5389.751 · Cited by 266 · see citing works
Ballantyne, C. M., Abate, N. I., Yuan, Ž., King, T. R., & Palmisano, J. J. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.11.023 · Cited by 238 · see citing works
Andrews, T. C., Ballantyne, C. M., Hsia, J. A., & Kramer, J. H. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00799-9 · Cited by 178 · see citing works
Chandler, C. E., Wilder, D. E., Pettini, J. L., Savoy, Y. E., Petras, S. F., Chang, G., Vincent, J., & Harwood, H. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300094-jlr200 · Cited by 177 · see citing works
The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups
GLOBE, D. R., Bayliss, M. S., & Harrison, D. J. (2009) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-7-62 · Cited by 148 · see citing works
Liao, W., Hui, T. Y., Young, S. G., & Davis, R. A. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300020-jlr200 · Cited by 113 · see citing works
Rader, D. J. (1993) · JAMA · doi:10.1001/jama.270.7.865 · Cited by 104 · see citing works
Self-citationRader, D. J. (1993) · JAMA · doi:10.1001/jama.1993.03510070087042 · Cited by 97 · see citing works
Self-citationComparative Evaluation of Fecal Fat Excretion Induced by Orlistat and Chitosan
Guerciolini, R., Radu‐Radulescu, L., Boldrin, M. N., Dallas, J., & Moore, R. (2001) · Obesity Research · doi:10.1038/oby.2001.47 · Cited by 77 · see citing works
MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises?
Burnett, J. R., & Watts, G. F. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.2.181 · Cited by 58 · see citing works
Kulich, K. R., Malfertheiner, P., Madisch, A., Labenz, J., Bayerdörffer, E., Miehlke, S., Carlsson, J., & Wiklund, I. K. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-62 · Cited by 56 · see citing works
Lipid-lowering effects of statins: a comparative review
Davidson, M. H., & Robinson, J. G. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.13.1701 · Cited by 51 · see citing works
Ikewaki, K., Rader, D. J., Zech, L. A., & Brewer, H. B. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39776-5 · Cited by 39 · see citing works
Self-citationAdverse Events With Concomitant Amiodarone and Statin Therapy
Alsheikh-Ali, A. A. A., & Karas, R. H. (2005) · Preventive Cardiology · doi:10.1111/j.1520-037x.2005.4060.x · Cited by 31 · see citing works
Sorbera, L. A., Martin, L., Silvestre, J. S., & Castañer, J. (2000) · Drugs of the Future · doi:10.1358/dof.2000.025.11.599755 · Cited by 13 · see citing works
Zaiss, S., & Sander, E. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(00)80611-5 · Cited by 4 · see citing works
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Cited by
Sorted by citations
Raal, F. J., Santos, R. D., Blom, D. J., Marais, A. D., Charng, M., Cromwell, W. C., Lachmann, R., Gaudet, D., Tan, J. L., Chasan-Taber, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60284-x · Cited by 921 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Cuchel, M., Meagher, E. A., du Toit Theron, H., Blom, D. J., Marais, A. D., Hegele, R. A., Averna, M. R., Sirtori, C. R., Shah, P. K., Gaudet, D., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61731-0 · Cited by 744 · see citing works
Self-citationStein, E. A., Gipe, D., Bergeron, J., Gaudet, D., Weiss, R., Dufour, R., Wu, R., & Pordy, R. C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60771-5 · Cited by 575 · see citing works
Lipoprotein(a): resurrected by genetics
Kronenberg, F., & Utermann, G. (2013) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02592.x · Cited by 521 · see citing works
Raal, F. J., Scott, R. C., Somaratne, R. M., Bridges, I. M., Li, G., Wasserman, S. M., & Stein, E. A. (2012) · Circulation · doi:10.1161/circulationaha.112.144055 · Cited by 502 · see citing works
Stein, E. A., Honarpour, N., Wasserman, S. M., Xu, F., Scott, R. C., & Raal, F. J. (2013) · Circulation · doi:10.1161/circulationaha.113.004678 · Cited by 330 · see citing works
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C. F., & Hussain, M. M. (2013) · Nature Medicine · doi:10.1038/nm.3200 · Cited by 301 · see citing works
Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia
Stein, E. A., Dufour, R., Gagné, C., Gaudet, D., East, C. A., Donovan, J. M., Chin, W., Tribble, D. L., & McGowan, M. P. (2012) · Circulation · doi:10.1161/circulationaha.112.104125 · Cited by 297 · see citing works
Lipid management in patients with chronic kidney disease
Ferro, C. J., Mark, P. B., Kanbay, M., Sarafidis, P. A., Heine, G. H., Rossignol, P., Massy, Z. A., Mallamaci, F., Valdivielso, J. M., Małyszko, J., et al. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0072-9 · Cited by 275 · see citing works
Rader, D. J., & Kastelein, J. J. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001292 · Cited by 264 · see citing works
Self-citationGenetic determinants of plasma triglycerides
Johansen, C. T., Kathiresan, S., & Hegele, R. A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r009720 · Cited by 258 · see citing works
Multiple functions of microsomal triglyceride transfer protein
Hussain, M. M., Rava, P., Walsh, M. T., Rana, M., & Iqbal, J. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-14 · Cited by 261 · see citing works
Feig, J. E., Parathath, S., Rong, J. X., Mick, S. L., Vengrenyuk, Y., Grauer, L., Young, S. G., & Fisher, E. A. A. (2011) · Circulation · doi:10.1161/circulationaha.110.984146 · Cited by 236 · see citing works
Human Genetics and the Causal Role of Lipoprotein(a) for Various Diseases
Kronenberg, F. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6648-3 · Cited by 227 · see citing works
Sahebkar, A., & Watts, G. F. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.06.019 · Cited by 181 · see citing works
Akdim, F., Visser, M. E., Tribble, D. L., Baker, B. F., Stroes, E. S. G., Yu, R. Z., Flaim, J., Su, J. Q., Stein, E. A., & Kastelein, J. J. P. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.01.003 · Cited by 178 · see citing works
The Severe Hypercholesterolemia Phenotype
Sniderman, A. D., Tsimikas, S., & Fazio, S. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.060 · Cited by 177 · see citing works
Sahebkar, A., & Watts, G. F. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-013-6479-4 · Cited by 176 · see citing works
Recent advances in pharmacotherapy for hypertriglyceridemia
Sahebkar, A., Chew, G. T., & Watts, G. F. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.07.002 · Cited by 166 · see citing works
Emerging RNA Therapeutics to Lower Blood Levels of Lp(a)
Tsimikas, S., Moriarty, P. M., & Stroes, E. S. G. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.051 · Cited by 155 · see citing works
Genetic determinants of hepatic steatosis in man
Hooper, A. J., Adams, L. A., & Burnett, J. R. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r008896 · Cited by 142 · see citing works
Gut-liver interaction in triglyceride-rich lipoprotein metabolism
Xiao, C., Hsieh, J., Adeli, K., & Lewis, G. F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00178.2011 · Cited by 126 · see citing works
The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis
Kuang, H., Yang, F., Zhang, Y., Wang, T., & Chen, G. (2018) · Cholesterol · doi:10.1155/2018/6303810 · Cited by 128 · see citing works
Severe Hypertriglyceridemia With Pancreatitis
Sacks, F. M., Stanesa, M., & Hegele, R. A. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13309 · Cited by 119 · see citing works
Pharmacological strategies for lowering LDL cholesterol: statins and beyond
Brautbar, A., & Ballantyne, C. M. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.2 · Cited by 114 · see citing works
Lipoprotein(a): more interesting than ever after 50 years
Dubé, J. B., Boffa, M. B., Hegele, R. A., & Koschinsky, M. L. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835111d8 · Cited by 105 · see citing works
New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs
Norata, G. D., Ballantyne, C. M., & Catapano, A. L. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht088 · Cited by 99 · see citing works
Current therapies for lowering lipoprotein (a)
van Capelleveen, J. C., van der Valk, F. M., & Stroes, E. S. G. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r053066 · Cited by 96 · see citing works
Fisher, E. A. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.02.001 · Cited by 93 · see citing works
Rutledge, A. C., Su, Q., & Adeli, K. (2010) · Biochemistry and Cell Biology · doi:10.1139/o09-168 · Cited by 91 · see citing works
Lipoprotein(a): A missing culprit in the management of athero‐thrombosis?
Ferretti, G., Bacchetti, T., Johnston, T. P., Banach, M., Pirro, M., & Sahebkar, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26050 · Cited by 92 · see citing works
Hooper, A. J., Burnett, J. R., & Watts, G. F. (2014) · Circulation Research · doi:10.1161/circresaha.116.304637 · Cited by 85 · see citing works
Mipomersen, an antisense apolipoprotein B synthesis inhibitor
Bell, D. A., Hooper, A. J., & Burnett, J. R. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.547471 · Cited by 84 · see citing works
<p>Lomitapide: a review of its clinical use, efficacy, and tolerability</p>
Alonso, R., Cuevas, A., & Mata, P. (2019) · Core Evidence · doi:10.2147/ce.s174169 · Cited by 81 · see citing works
Regulation of chylomicron production in humans
Xiao, C., & Lewis, G. F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.019 · Cited by 77 · see citing works
New approaches to target microsomal triglyceride transfer protein
Hussain, M. M., & Bakillah, A. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328312707c · Cited by 78 · see citing works
Lomitapide for the treatment of hypercholesterolemia
Berberich, A. J., & Hegele, R. A. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1340941 · Cited by 77 · see citing works
The renaissance of lipoprotein(a): Brave new world for preventive cardiology?
Ellis, K. L., Boffa, M. B., Sahebkar, A., Koschinsky, M. L., & Watts, G. F. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.09.001 · Cited by 71 · see citing works
Stein, E. A., Bays, H. E., O’Brien, D., Pedicano, J., Piper, E., & Spezzi, A. (2011) · Circulation · doi:10.1161/circulationaha.110.975284 · Cited by 70 · see citing works
Cholesterol Metabolism: A Double-Edged Sword in Hepatocellular Carcinoma
Zhou, F., & Sun, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.762828 · Cited by 66 · see citing works
Bhatia, H. S., & Wilkinson, M. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11206040 · Cited by 64 · see citing works
New lipid-lowering drugs: an update
Wierzbicki, A. S., Hardman, T. C., & Viljoen, A. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02867.x · Cited by 65 · see citing works
Șerban, M.-C., Sahebkar, A., Mikhailidis, D. P., Toth, P. P., Jones, S. R., Muntner, P., Blaha, M. J., Andrica, F., Martin, S. S., Borza, C., et al. (2016) · Scientific Reports · doi:10.1038/srep19188 · Cited by 65 · see citing works
Microsomal transfer protein inhibition in humans
Cuchel, M., & Rader, D. J. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32836139df · Cited by 63 · see citing works
Self-citationEmerging therapeutic agents to lower lipoprotein (a) levels
Kolski, B. C., & Tsimikas, S. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283598d81 · Cited by 63 · see citing works
Control of chylomicron export from the intestine
Mansbach, C. M., & Siddiqi, S. A. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00228.2015 · Cited by 61 · see citing works
Lipoprotein(a): a risk factor for atherosclerosis and an emerging therapeutic target
Fusco, S. A. D., Arca, M., Scicchitano, P., Alonzo, A., Perone, F., Gulizia, M. M., Gabrielli, D., Oliva, F. G., Imperoli, G., & Colivicchi, F. (2022) · Heart · doi:10.1136/heartjnl-2021-320708 · Cited by 61 · see citing works
Josekutty, J., Iqbal, J., Iwawaki, T., Kohno, K., & Hussain, M. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459602 · Cited by 59 · see citing works
MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice
Irani, S., Pan, X., Peck, B. C. E., Iqbal, J., Sethupathy, P., & Hussain, M. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.728451 · Cited by 57 · see citing works
Insights from human congenital disorders of intestinal lipid metabolism
Levy, E. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r052415 · Cited by 56 · see citing works
Allelic and phenotypic spectrum of plasma triglycerides
Johansen, C. T., & Hegele, R. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.007 · Cited by 56 · see citing works
An Overview of the New Frontiers in the Treatment of Atherogenic Dyslipidemias
Rached, F. H., Chapman, M. J., & Kontush, A. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.85 · Cited by 54 · see citing works
Molecular pathways and agents for lowering LDL-cholesterol in addition to statins
Costet, P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.006 · Cited by 53 · see citing works
New Frontiers in Lp(a)-Targeted Therapies
Borrelli, M. J., Youssef, A., Boffa, M. B., & Koschinsky, M. L. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.01.004 · Cited by 53 · see citing works
Kronenberg, F. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_504 · Cited by 53 · see citing works
Combination therapy in dyslipidemia: Where are we now?
Catapano, A. L., Farnier, M., Foody, J. M., Toth, P. P., Tomassini, J. E., Brudi, P., & Tershakovec, A. M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.026 · Cited by 52 · see citing works
Current Options and Future Perspectives in the Treatment of Dyslipidemia
Muscoli, S., Ifrim, M., Russo, M., Candido, F., Sanseviero, A., Milite, M., Luozzo, M. D., Marchei, M., & Sangiorgi, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164716 · Cited by 52 · see citing works
Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer
Irani, S., & Hussain, M. M. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000162 · Cited by 50 · see citing works
Kotani, K., Șerban, M.-C., Penson, P. E., Lippi, G., & Banach, M. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1188055 · Cited by 50 · see citing works
Inflammation and beyond: new directions and emerging drugs for treating atherosclerosis
Bertrand, M.-J., & Tardif, J. (2016) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2017.1269743 · Cited by 51 · see citing works
Lipoprotein(a) and cardiovascular disease
Boffa, M. B., & Koschinsky, M. L. (2024) · Biochemical Journal · doi:10.1042/bcj20240037 · Cited by 47 · see citing works
Crouchet, É., Wrensch, F., Schuster, C., Zeisel, M. B., & Baumert, T. F. (2018) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284818759483 · Cited by 47 · see citing works
Dietary natural products as emerging lipoprotein(a)‐lowering agents
Momtazi‐Borojeni, A. A., Katsiki, N., Pirro, M., Banach, M., Al‐Rasadi, K., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28134 · Cited by 46 · see citing works
Familial Hypercholesterolemia: Present and Future Management
Sjouke, B., Kusters, D. M., Kastelein, J. J. P., & Hovingh, G. K. (2011) · Current Cardiology Reports · doi:10.1007/s11886-011-0219-9 · Cited by 44 · see citing works
Pharmacotherapies for lipid modification: beyond the statins
Gotto, A. M., & Moon, J. E. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.117 · Cited by 44 · see citing works
Kim, E., Campbell, A. S., Schueller, O. J. A., Wong, E., Cole, B., Kuo, J. J., Ellis, J. L., Ferkany, J. W., & Sweetnam, P. M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177527 · Cited by 42 · see citing works
New Therapies for Reducing Low-Density Lipoprotein Cholesterol
Stein, E. A., & Raal, F. J. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.08.008 · Cited by 42 · see citing works
Novel nonstatin strategies to lower low-density lipoprotein cholesterol
Davidson, M. H. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0011-0 · Cited by 38 · see citing works
Tuteja, S., Duffy, D., Dunbar, R. L., Movva, R., Gadi, R., Bloedon, L. T., & Cuchel, M. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1351 · Cited by 36 · see citing works
Self-citationNew Therapeutic Approaches in Treatment of Dyslipidaemia—A Narrative Review
Merćep, I., Strikić, D., Slišković, A. M., & Reiner, Ž. (2022) · Pharmaceuticals · doi:10.3390/ph15070839 · Cited by 37 · see citing works
Statin Intolerance: Diagnosis and Remedies
Pirillo, A., & Catapano, A. L. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0582-z · Cited by 35 · see citing works
Lomitapide: A Review of its Use in Adults with Homozygous Familial Hypercholesterolemia
Perry, C. M. (2013) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-013-0030-7 · Cited by 35 · see citing works
Atherosclerosis: Recent trials, new targets and future directions
Ladeiras‐Lopes, R., Agewall, S., Tawakol, A. A., Staels, B., Stein, E. A., Mentz, R. J., Leite-Moreira, A. F., Zannad, F. M., & Köenig, W. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.013 · Cited by 34 · see citing works
Other Therapies for Reducing Low-Density Lipoprotein Cholesterol: Medications in Development
Stein, E. A. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.11.011 · Cited by 34 · see citing works
Diagnosis and treatment of severe hypertriglyceridemia
Viljoen, A., & Wierzbicki, A. S. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.21 · Cited by 34 · see citing works
Novel therapies and new targets of treatment for familial hypercholesterolemia
Goldberg, A. C. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.08.015 · Cited by 33 · see citing works
Lipoprotein(a) in postmenopausal women: assessment of cardiovascular risk and therapeutic options
Anagnostis, P. G., Karras, S. Ν., Lambrinoudaki, I. V., Stevenson, J. C., & Goulis, D. G. (2016) · International Journal of Clinical Practice · doi:10.1111/ijcp.12903 · Cited by 34 · see citing works
Youssef, A., Clark, J. R., Marcovina, S. M., Boffa, M. B., & Koschinsky, M. L. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317335 · Cited by 33 · see citing works
Walsh, M. T., & Hussain, M. M. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1221883 · Cited by 32 · see citing works
Vuorio, A. F., Tikkanen, M. J., & Kovanen, P. T. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s36641 · Cited by 32 · see citing works
Sirtori, C. R., Pavanello, C., & Bertolini, S. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.931100 · Cited by 31 · see citing works
Lipoprotein(a) in clinical practice: New perspectives from basic and translational science
Scipione, C. A., Koschinsky, M. L., & Boffa, M. B. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1415866 · Cited by 33 · see citing works
Lomitapide for the treatment of hypertriglyceridemia
Berberich, A. J., & Hegele, R. A. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1254187 · Cited by 29 · see citing works
Stein, E. A., & Raal, F. J. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6654-5 · Cited by 28 · see citing works
Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol
Badia, L. A. D., Elshourbagy, N. A., & Mousa, S. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.011 · Cited by 28 · see citing works
Koschinsky, M. L., & Boffa, M. B. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.08.002 · Cited by 27 · see citing works
Emerging low-density lipoprotein therapies: Microsomal triglyceride transfer protein inhibitors
Goldberg, A. C. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.03.003 · Cited by 27 · see citing works
Poller, W. C., Berger, A., Dreger, H., Morgera, S., & Enke-Melzer, K. (2017) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2017.05.007 · Cited by 27 · see citing works
Dhote, V. V., Joharapurkar, A. A., Kshirsagar, S. G., Dhanesha, N., PATEL, V. G., Patel, A., Raval, S., & Jain, M. R. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05513.x · Cited by 27 · see citing works
New Therapeutic Approaches for Familial Hypercholesterolemia
Ajufo, E., & Rader, D. J. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-051215-030943 · Cited by 25 · see citing works
Self-citationIrani, S., Iqbal, J., Antoni, W. J., Ijaz, L., & Hussain, M. M. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081299 · Cited by 26 · see citing works
Beyond Statins: New Lipid Lowering Strategies to Reduce Cardiovascular Risk
Noto, D., Cefalu, A. B., & Averna, M. R. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0414-4 · Cited by 25 · see citing works
Efficacy and Safety of Lomitapide in Hypercholesterolemia
Liu, X., Men, P., Wang, Y., Zhai, S., Zhao, Z., & Liu, C. (2017) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-017-0214-7 · Cited by 26 · see citing works
Khoury, É., Brisson, D., Roy, N., Tremblay, G., & Gaudet, D. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1602606 · Cited by 25 · see citing works
Severe familial hypercholesterolaemia: Current and future management
Farnier, M., & Bruckert, É. (2012) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2012.05.011 · Cited by 24 · see citing works
Moens, S. J. B., van Capelleveen, J. C., & Stroes, E. S. G. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000130 · Cited by 24 · see citing works
New therapies to reduce low-density lipoprotein cholesterol
Wierzbicki, A. S., Viljoen, A., Hardman, T. C., & Mikhailidis, D. P. (2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283605fa2 · Cited by 24 · see citing works
Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus
Brouwers, M. C. G. J., Graaf, J. D., van Greevenbroek, M. M. J., Schaper, N. C., Stehouwer, C. D. A., & Stalenhoef, A. F. H. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833ea9ec · Cited by 24 · see citing works
- Authors
- Samaha, F. F., McKenney, J., Bloedon, L. T., Sasiela, W. J., & Rader, D. J.
- Affiliations
- Philadelphia VA Medical Center (US)
- Virginia Commonwealth University (US)
- University of Pennsylvania (US)
- Aegerion Pharmaceuticals (United States) (US)
- Corresponding author
- Samaha, Frederick F
- Venue
- Nature Clinical Practice Cardiovascular Medicine
- Published
- 2008-05-27
- Volume
- 5
- Issue
- 8
- Pages
- 497-505
- ISSN
- 1743-4297 (ISSN-L)
- 1743-4300
- OpenAlex
- W2046959088
- Cited by
- 220
- References
- 31
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 11 · 2023: 4 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 15 · 2015: 18 · 2014: 29 · 2013: 27 · 2012: 23
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- microsomal triglyceride transfer protein, MTP inhibitors, ezetimibe, hypercholesterolemia, LDL cholesterol lowering, combination lipid-lowering therapy, dose titration, transaminase elevation, drug safety, coronary artery disease, statin intolerance, treatment response variability, triglyceride-rich lipoproteins
- MeSH terms
- Ezetimibe, Aged, Anticholesteremic Agents, Azetidines, Benzimidazoles, Carrier Proteins, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Hypercholesterolemia, Cholesterol, LDL, Male, Microsomes, Middle Aged, Severity of Illness Index, Treatment Outcome
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