Cited by 179Cell death mechanisms and regulationCancer-related Molecular PathwaysAutophagy in Disease and Therapy

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Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

Reed, John C·2006·Nature Clinical Practice Oncology

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Abstract

Cell death is a normal facet of human physiology, ensuring tissue homeostasis by offsetting cell production with cell demise. Neoplasms arise in part because of defects in physiological cell death mechanisms, contributing to pathological cell expansion. Defects in normal cell death pathways also contribute to cancer progression by permitting progressively aberrant cell behaviors, while also desensitizing tumor cells to immune-mediated attack, radiation, and chemotherapy. Through basic research, much has been learned about the molecular mechanisms responsible for cell turnover and how tumors escape cell death. By exploiting this knowledge base, several innovative strategies for eradicating malignancies have materialized that are based on restoration of natural pathways for cell autodestruction. Some of these strategies have advanced into human clinical trials. Several of the current strategies based on targeting core components of the cell death machinery for cancer therapy are reviewed here, and a summary of progress toward clinical applications is provided.

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Hyer ML et al.: The FLIP-side of Fas (CD95) signaling. Clin Cancer Res, in press

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See all 179

Authors: Reed, J. C.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Reed, John C
ORCID: Reed, John C
Venue: Nature Clinical Practice Oncology
Publisher: Springer Science and Business Media LLC
Published: 2006-07
Volume: 3
Issue: 7
Pages: 388-398
ISSN: 1743-4254 (ISSN-L)
1743-4262
DOI: 10.1038/ncponc0538
OpenAlex: W2125192217
Cited by: 179
References: 81
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2020: 5 · 2018: 2 · 2017: 7 · 2016: 5 · 2015: 14 · 2014: 7 · 2013: 9 · 2012: 11
FWCI: 1.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Clinical Practice Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: cancer therapy, cell death pathways, apoptosis, epigenetic regulators, gene therapy, tumor immune evasion, tumor progression, clinical trials, cell turnover
MeSH terms: Antineoplastic Agents, Clinical Trials as Topic, Humans, Mitochondria, Neoplasms, Signal Transduction, Cell Death, Apoptosis, Apoptosis Regulatory Proteins, Inhibitor of Apoptosis Proteins, TNF-Related Apoptosis-Inducing Ligand

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Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

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