Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, Johannes, Tukiainen, Taru, Sarin, Antti-Pekka, Ortega-Alonso, Alfredo, Tikkanen, Emmi, Lyytikäinen, Leo-Pekka, Kangas, Antti J, Soininen, Pasi +23 more·2012·Nature Genetics
DOI 10.1038/ng.1073
Cited by (557)
Items 101–200 of 557
- Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimatesQin Wang, Antti J. Kangas, Pasi Soininen, M. Tiainen, Tuulia Tynkkynen, Katri S. Puukka, A Ruokonen, Jorma S.A. Viikari, Mika A. P. Kähönen, Terho J. Lehtimäki et al. · 2015 · International Journal of Epidemiology
- Metabolomic and Genome‐wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1Sook Wah Yee, MM Giacomini, C‐H Hsueh, D Weitz, Xiaomin Liang, S Goswami, Jason Michael Kinchen, A Coelho, Arik A. Zur, Katharina Mertsch et al. · 2016 · Clinical Pharmacology & Therapeutics
- Evolutionary history and adaptation of a human pygmy population of Flores Island, IndonesiaTucci, Serena, Vohr, Samuel H., McCoy, Rajiv C., Vernot, Benjamin, Robinson, Matthew R., Barbieri, Chiara, Nelson, Brad J., Fu, Wenqing, Purnomo, Gludhug A., Sudoyo, Herawati et al. · 2018 · Science
- Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesityAlexessander Couto Alves, B. Valcarcel, V-P Mäkinen, Laure C. Morin-Papunen, Sylvain P Sebert, Antti J. Kangas, Pasi Soininen, Shikta Das, Maria De Iorio, Lachlan Coin et al. · 2017 · International Journal of Obesity
- Translational regulation shapes the molecular landscape of complex disease phenotypesSebastian Schäfer, Eleonora Adami, Matthias Heinig, Katharina E. Costa Rodrigues, Franziska Kreuchwig, Jan Šilhavý, Sebastiaan van Heesch, Deimantė Šimaitė, Nikolaus Rajewsky, Edwin P. J. G. Cuppen et al. · 2015 · Nature Communications
- Application of the Metabolomics Approach in Food AuthenticationJinap Selamat, Nur Amalyn Alyaa Rozani, Suganya Murugesu · 2021 · Molecules
- Functional implications of Neandertal introgression in modern humansDannemann, Michael, Prüfer, Kay, Kelso, Janet · 2017 · Genome biology
- Identifying the genomic determinants of aging and longevity in human population studies: Progress and challengesJoris Deelen, Marian Beekman, Miriam Capri, Claudio Franceschi, P. Eline Slagboom · 2013 · BioEssays
- Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohortsDiana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala‐Korpela, George Davey Smith, Marjo‐Riitta Järvelin, Debbie A. Lawlor · 2017 · PLoS Medicine
- Dietary adaptation of FADS genes in Europe varied across time and geographyKaixiong Ye, Feng Gao, David Wang, Ofer Bar‐Yosef, Alon Keinan · 2017 · Nature Ecology & Evolution
- Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease LinksRico Rueedi, Mirko Ledda, Andrew W. Nicholls, Reza M. Salek, Pedro Manuel Marques-Vidal, Edgard Morya, Koichi Sameshima, Ivan Montoliu, Laeticia Da Silva, Sebastiano Collino et al. · 2014 · PLoS Genetics
- Serum metabolic profiles in overweight and obese women with and without metabolic syndromePetri Wiklund, Satu Pekkala, Reija Autio, Eveliina Munukka, Leiting Xu, Juha T Saltevo, Shumei Cheng, Urho M. Kujala, Markku Alén, Sulin Cheng · 2014 · Diabetology & Metabolic Syndrome
- The evolution of genome-scale models of cancer metabolismLewis, Nathan E., Abdel-Haleem, Alyaa M. · 2013 · Frontiers in Physiology
- A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese populationRajkumar Dorajoo, Ye Ji Sun, Yi Ying Han, Tingjing Ke, Ayala Burger, Xuling Chang, Hui Qi Low, Weihua Guan, Rozenn N. Lemaître, Chiea Chuen Khor et al. · 2015 · Genes & Nutrition
- Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss DietsMin Xu, Qibin Qi, Jun Liang, George A. Bray, Frank B. Hu, Frank M. Sacks, Lu Qi · 2013 · Circulation
- Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthmaJanina S. Ried, Hansjörg Baurecht, Ferdinand Stückler, Jan Krumsiek, Christian Gieger, Joachim Heinrich, Michael Kabesch, Cornelia P. Prehn, Annette Peters, Elke Rodríguez et al. · 2013 · Allergy
- Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker DiscoveryDaisuke Saigusa, Yasunobu Okamura, Ikuko N. Motoike, Yasutake Katoh, Kurosawa Yasuhiro, Reina Saijo, S. Koshiba, Jun Yasuda, Hozumi Motohashi, Junichi Sugawara et al. · 2016 · PLoS ONE
- Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degenerationİlhan E. Acar, Laura Lorés‐Motta, Johanna Maria Colijn, Magda A. Meester‐Smoor, Timo Verzijden, Audrey Cougnard‐Grégoire, Soufiane Ajana, Bénédicte M. J. Merle, Anita de Breuk, Thomas J. Heesterbeek et al. · 2020 · Ophthalmology
- Genetic study links components of the autonomous nervous system to heart-rate profile during exerciseNiek Verweij, Yordi J. van de Vegte, Pim van der Harst · 2018 · Nature Communications
- Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis PathogenesisRoxana Coras, Jessica Murillo‐Saich, Mónica Gumá · 2020 · Cells
- Integrated Metabolomics and GenomicsSvati Hasmukh Shah, Christopher B. Newgard · 2015 · Circulation Cardiovascular Genetics
- Ketone body production is differentially altered in steatosis and non‐alcoholic steatohepatitis in obese humansVille Männistö, Marko Simonen, Jenni Hyysalo, Pasi Soininen, Antti J. Kangas, Dorota Kamińska, Ananda K. Matte, Sari Venesmaa, Pirjo Käkelä, Vesa J. Kärjä et al. · 2014 · Liver International
- Systems biology strategies to study lipidomes in health and diseaseTuulia Hyötyläinen, Matej Orešič · 2014 · Progress in Lipid Research
- Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndromeEmma Raitoharju, Ilkka Seppälä, Niku Oksala, Leo‐Pekka Lyytikäinen, Olli Tuomas Raitakari, Jorma S.A. Viikari, Mika Ala‐Korpela, Pasi Soininen, Antti J. Kangas, Mélanie Waldenberger et al. · 2014 · Molecular and Cellular Endocrinology
- The emergence of proton nuclear magnetic resonance metabolomics in the cardiovascular arena as viewed from a clinical perspectiveNaomi Rankin, David Preiss, Paul I. Welsh, Karl E. Burgess, Scott McGill Nelson, Debbie A. Lawlor, Naveed A. Sattar · 2014 · Atherosclerosis
- Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platformsİdil Yet, Cristina Menni, So–Youn Shin, Massimo Mangino, Nicole Soranzo, Jerzy Adamski, Karsten Suhre, Tim D. Spector, Gabi Kastenmüller, Jordana T. Bell · 2016 · PLoS ONE
- Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi‐stage genome‐wide association studyYimin Zhu, Dandan Zhang, Dan Zhou, Zhenli Li, Zhiqiang Li, Le Fang, Min Yang, Zhongyan Shan, Hong Li, Jianhua Chen et al. · 2017 · Journal of Cellular and Molecular Medicine
- Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trialRhona A. Beynon, Rebecca Claire Richmond, Diana L. Santos Ferreira, Andy Ness, Margaret May, George Davey Smith, Emma E. Vincent, Charleen D. Adams, Mika Ala‐Korpela, Peter Würtz et al. · 2018 · International Journal of Cancer
- Precision Medicine and Personalized Medicine in Cardiovascular DiseaseGemma E. Currie, Christian Delles · 2018 · Advances in experimental medicine and biology
- Innovation in metabolomics to improve personalized healthcareStefano Cacciatore, Massimo F. Loda · 2015 · Annals of the New York Academy of Sciences
- Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence AnalysesAyşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish K. Dharuri, Najaf Amin, Jan Bert van Klinken, Lennart C. Karssen, Boukje de Vries, Axel Meissner, Sibel Göraler et al. · 2015 · PLoS Genetics
- Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage CompensationTaru Tukiainen, Matti Pirinen, Antti‐Pekka Sarin, Claes Ladenvall, Johannes Kettunen, Terho J. Lehtimäki, Marja‐Liisa Lokki, Markus Perola, Juha P. Sinisalo, Efthymia Vlachopoulou et al. · 2014 · PLoS Genetics
- Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) StudyMithun Das, Jin Sha, Bertha Hidalgo, Stella W. Aslibekyan, Anh N. Do, Degui Zhi, Dianjianyi Sun, Tao Zhang, Shengxu Li, Wei Chen et al. · 2016 · PLoS ONE
- Differential effects of PCSK9 variants on risk of coronary disease and ischaemic strokeJemma C. Hopewell, Rainer Malik, Elsa Valdés‐Márquez, Bradford B. Worrall, Rory Collins · 2017 · European Heart Journal
- Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomicsDaisuke Saigusa, Naomi Matsukawa, Eiji Hishinuma, S. Koshiba · 2020 · Drug Metabolism and Pharmacokinetics
- Mining the Human Phenome Using Allelic Scores That Index Biological IntermediatesDavid M. Evans, Marie‐Jo Brion, Lavinia Paternoster, John P. Kemp, George McMahon, Marcus Robert Munafo, John B. Whitfield, Sarah Elizabeth Medland, Grant W. Montgomery, Nicholas John Timpson et al. · 2013 · PLoS Genetics
- Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analysesAnatoliy I. Yashin, Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin G. Arbeev, Igor V. Akushevich, Alexander M. Kulminski, Irina V. Culminskaya, Ilya Y. Zhbannikov et al. · 2017 · Experimental Gerontology
- Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levelsFabrice Danjou, Magdalena Żołędziewska, Carlo Sidore, Maristella Steri, Fabio Busonero, Andrea Maschio, Antonella Mulas, Lucia Perseu, Susanna Barella, Eleonora Porcu et al. · 2015 · Nature Genetics
- A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intakeLeticia Goñi, Marta Cuervo, Fermin Ignacio Milagro, José Alfredo Martínez · 2014 · Genes & Nutrition
- Genome-wide association studies with metabolomicsJerzy Adamski · 2012 · Genome Medicine
- An exome array study of the plasma metabolomeEugene P. Rhee, Qiong Yang, Bing Yu, Xuan Liu, Susan C. Cheng, Amy Deik, Kerry A. Pierce, Kevin H. Bullock, Jennifer E. Ho, Daniel A Levy et al. · 2016 · Nature Communications
- Methods for meta‐analysis of multiple traits using GWAS summary statisticsDebashree Ray, Michael Boehnke · 2017 · Genetic Epidemiology
- Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseasesRubina Tabassum, Samuli Ripatti · 2021 · Cellular and Molecular Life Sciences
- Abdominal obesity and circulating metabolites: A twin study approachLeonie Helen Bogl, Sanna M. Kaye, Joel T Rämö, Antti J. Kangas, Pasi Soininen, Antti Hakkarainen, Jesper Lundbom, Nina M I Lundbom, Alfredo Ortega‐Alonso, Aila Rissanen et al. · 2015 · Metabolism
- Metabolomics: population epidemiology and concordance in Australian children aged 11–12 years and their parentsSusan Ellul, Melissa A Wake, Susan A Clifford, Katherine Lange, Peter Würtz, Markus Juonala, Terence Dwyer, John B. Carlin, David Paul Burgner, Richard Saffery · 2019 · BMJ Open
- Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease PhenotypesChen Yao, Brian H. Chen, Roby Joehanes, Burçak Otlu, Xiaoling Zhang, Chunyu Liu, Tianxiao Huan, Öznur Taştan, L. Adrienne Cupples, James B. Meigs et al. · 2014 · Circulation
- Gender-Dependent Associations of Metabolite Profiles and Body Fat Distribution in a Healthy Population with Central Obesity: Towards Metabolomics DiagnosticsEwa Szymańska, Jildau Bouwman, Katrin Strassburg, Jacques J. M. Vervoort, Antti J. Kangas, Pasi Soininen, Mika Ala‐Korpela, Johan A. Westerhuis, John van Duynhoven, David J. Mela et al. · 2012 · OMICS A Journal of Integrative Biology
- Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancyWilliam L. Lowe, J. Karban · 2013 · Diabetic Medicine
- Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)Maria Anneli Lankinen, Marjukka Kolehmainen, Tiina J. Jääskeläinen, Jussi Paananen, Laura Joukamo, Antti J. Kangas, Pasi Soininen, Kaisa S Poutanen, Hannu M Mykkänen, Helena Gylling et al. · 2014 · PLoS ONE
- Optimization of large-scale pseudotargeted metabolomics method based on liquid chromatography–mass spectrometryPing Luo, Peiyuan Yin, Weijian Zhang, Lina Zhou, Xin Lu, Xiaohui Lin, Guowang Xu · 2016 · Journal of Chromatography A
- A comprehensive transcriptome analysis of skeletal muscles in two Polish pig breeds differing in fat and meat quality traitsKatarzyna Piórkowska, Kacper Żukowski, Katarzyna Ropka‐Molik, M. Tyra, Artur Gurgul · 2018 · Genetics and Molecular Biology
- Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementiaShizhen Tang, Aron S. Buchman, Philip L. De Jager, David Alan Bennett, Michael P. Epstein, Jingjing Yang · 2021 · PLoS Genetics
- Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milkBart Buitenhuis, Ulrik Kræmer Sundekilde, Nina Aagaard Poulsen, Hanne Christine Bertram, Lotte Bach Larsen, Peter Borgen Sørensen · 2013 · Journal of Dairy Science
- Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford CohortKurt Taylor, Diana L. Santos Ferreira, Jane West, Tiffany Yang, Massimo Caputo, Debbie A. Lawlor · 2019 · Metabolites
- Long term conservation of human metabolic phenotypes and link to heritabilityNoha A. Yousri, Gabi Kastenmüller, Christian Gieger, So–Youn Shin, İdil Yet, Cristina Menni, Annette Peters, Christa Meisinger, Robert P. Mohney, Thomas Illig et al. · 2014 · Metabolomics
- Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn’s DiseaseElizabeth Scoville, Margaret M. Allaman, Dawn Wiese Adams, Amy K. Motley, Shannon C. Peyton, Sarah L. Ferguson, Sara Horst, Christopher S. Williams, Dawn Borromeo Beaulieu, David A. Schwartz et al. · 2019 · Scientific Reports
- Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypesMarc‐Emmanuel Dumas · 2012 · Molecular BioSystems
- Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluidJurjen Justin Luykx, S C Bakker, Eef G.W.M. Lentjes, M Neeleman, Eric Strengman, Lara J. Mentink, Joseph A. DeYoung, Simone de Jong, Jae Hoon Sul, Eleazar Eskin et al. · 2013 · Molecular Psychiatry
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease ResearchMarilyn C. Cornelis, Frank B. Hu · 2013 · Current Nutrition Reports
- Mixing omics: combining genetics and metabolomics to study rheumatic diseasesCristina Menni, Jonas Zierer, Ana Maria Valdes, Tim D. Spector · 2017 · Nature Reviews Rheumatology
- LDL cholesterol still a problem in old age? A Mendelian randomization studyIris Postmus, Joris Deelen, Sanaz Sedaghat, Stella Trompet, Anton J.M. de Craen, Bastiaan T. Heijmans, Oscar H. Franco, Albert Hofman D, Abbas Dehghan, P. Eline Slagboom et al. · 2015 · International Journal of Epidemiology
- Computational approaches for systems metabolomicsJan Krumsiek, Jörg Bartel, Fabian Joachim Theis · 2016 · Current Opinion in Biotechnology
- Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in FinnsSliz, Eeva, Kalaoja, Marita, Ahola-Olli, Ari, Raitakari, Olli, Perola, Markus, Salomaa, Veikko, Lehtimäki, Terho, Karhu, Toni, Viinamäki, Heimo, Salmi, Marko et al. · 2019 · Journal of Medical Genetics
- Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancerZsuzsanna Ament, Mojgan Masoodi, Julian Leether Griffin · 2012 · Genome Medicine
- From Metabonomics to Pharmacometabonomics: The Role of Metabolic Profiling in Personalized MedicineJeremy Ramsey Everett · 2016 · Frontiers in Pharmacology
- Omics research project on prospective cohort studies from the Tohoku Medical Megabank ProjectS. Koshiba, Ikuko N. Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama et al. · 2018 · Genes to Cells
- Triglyceride‐cholesterol imbalance across lipoprotein subclasses predicts diabetic kidney disease and mortality in type 1 diabetes: the FinnDiane StudyVille‐Petteri Mäkinen, Pasi Soininen, Antti J. Kangas, Carol M. Forsblom, Nina Tolonen, Lena M. Thorn, Jorma S.A. Viikari, Olli Tuomas Raitakari, Markku J. Savolainen, Per‐Henrik Groop et al. · 2013 · Journal of Internal Medicine
- Analysis of Metabolic Syndrome Components in >15 000 African Americans Identifies Pleiotropic VariantsCara L. Carty, Samsiddhi Bhattacharjee, Jeff Haessler, Iona C. Cheng, Lucia A. Hindorff, Vanita R. Aroda, Christopher S. Carlson, Chun-Nan Hsu, Lynne Ross Wilkens, Simin Liu et al. · 2014 · Circulation Cardiovascular Genetics
- Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein CholesterolTamara S. Roman, Amanda F. Marvelle, Marie P. Fogarty, Swarooparani Vadlamudi, Arlene J. Gonzalez, Martin L. Buchkovich, Jeroen R. Huyghe, Christian Fuchsberger, Anne Jackson, Ying Wu et al. · 2015 · The American Journal of Human Genetics
- Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites LevelsPirro G. Hysi, Massimo Mangino, Paraskevi Christofidou, Mario Falchi, Edward D. Karoly, NIHR Bioresource Investigators, Robert P. Mohney, Ana Maria Valdes, Tim D. Spector, Cristina Menni · 2022 · Metabolites
- An APOA5 3′ UTR Variant Associated with Plasma Triglycerides Triggers APOA5 Downregulation by Creating a Functional miR-485-5p Binding SiteCyrielle Caussy, Sybil Charrière, Christophe Marçais, Mathilde Di Filippo, Agnès Sassolas, Mireille Delay, Vanessa Euthine, Audrey Jalabert, Étienne Lefai, Sophie Rome et al. · 2014 · The American Journal of Human Genetics
- Cohort Profile: The Oxford BiobankFredrik Karpe, Senthil Kandaswamy Vasan, Sandy M. Humphreys, John M. Miller, Jane Cheeseman, Andrea Dennis, Matt J. Neville · 2017 · International Journal of Epidemiology
- Role of plasma kallikrein in diabetes and metabolismQunfang Zhou, Ward Fickweiler, Edward P. Feener · 2013 · Thrombosis and Haemostasis
- Biochemical insights from population studies with genetics and metabolomicsKarsten Suhre, Johannes Raffler, Gabi Kastenmüller · 2015 · Archives of Biochemistry and Biophysics
- A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association StudiesJingjing Yang, Lars G. Fritsche, Xiang Zhou, Gonçalo R. Abecasis · 2017 · The American Journal of Human Genetics
- Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trialPetra S. Larmo, Antti J. Kangas, Pasi Soininen, Henna-Maria Lehtonen, Jukka‐Pekka Suomela, Baoru Yang, Jorma S.A. Viikari, Mika Ala‐Korpela, Heikki P. T. Kallio · 2013 · American Journal of Clinical Nutrition
- Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black IndividualsUsman A. Tahir, Daniel H. Katz, Julián Ávila-Pacheco, Alexander G. Bick, Akhil Pampana, Jeremy Robbins, Zhi Yu, Zsu‐Zsu Chen, Mark D. Benson, Daniel E. Cruz et al. · 2022 · Nature Communications
- Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM studyJames P. Davis, Jeroen R. Huyghe, Adam E. Locke, Anne Jackson, Xueling Sim, Heather M. Stringham, Tanya M. Teslovich, Ryan Welch, Christian Fuchsberger, Narisu Narisu et al. · 2017 · PLoS Genetics
- Genetic Determinants of P Wave Duration and PR SegmentNiek Verweij, Irene Mateo Leach, Malou van den Boogaard, Dirk Jan van Veldhuisen, Vincent M. Christoffels, LifeLines Cohort Study, Hans L. Hillege, Wiek H. van Gilst, Phil Barnett, Rudolf A. de Boer et al. · 2014 · Circulation Cardiovascular Genetics
- Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traitsAnanyo Choudhury, Jean‐Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwendé Romuald Boua, Nigel John Crowther, Godfred Agongo, Gershim Asiki, Francesc Xavier Gómez-Olivé, Isaac Kisiangani et al. · 2022 · Nature Communications
- Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traitsNathan Pankratz, Ursula M. Schick, Yingchang Lu, Erwin P. Böttinger, Ruth J. F. Loos, Alex P. Reiner, Yi Zhou, Elliott J. Hagedorn, Bella Hu, Vy M. Nguyen et al. · 2016 · Nature Genetics
- Endogenous Production of Long-Chain Polyunsaturated Fatty Acids and Metabolic Disease RiskHarvey J. Murff, Todd L. Edwards · 2014 · Current Cardiovascular Risk Reports
- Gene–diet interaction and weight lossLu Qi · 2013 · Current Opinion in Lipidology
- Do nuclear magnetic resonance (NMR)-based metabolomics improve the prediction of pregnancy-related disorders? Findings from a UK birth cohort with independent validationNancy McBride, Sara L. White, Poston Lucilla, Diane Farrar, Jane West, Naveed A. Sattar, Scott McGill Nelson, John Wright, Dan Mason, Matthew J Suderman et al. · 2020 · BMC Medicine
- Integration of genomics and metabolomics for prioritization of rare disease variants: a 2018 literature reviewEmma Graham, Jessica K. Lee, Magda Price, Maja Tarailo‐Graovac, Allison Matthews, Udo F. H. Engelke, Jeffrey S. Tang, Leo A. J. Kluijtmans, Ron A. Wevers, Wyeth W. Wasserman et al. · 2018 · Journal of Inherited Metabolic Disease
- Global metabolic profiling to model biological processes of aging in twinsBryan Bunning, Kévin Contrepois, Brittany Lee‐McMullen, Gopal Krishna Dhondalay, Wenming Zhang, Dana Tupa, Olivia Raeber, Manisha Desai, Kari Christine Nadeau, Michael P. Snyder et al. · 2019 · Aging Cell
- Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport MechanismsYong Li, Peggy Sekula, Matthias Wuttke, Judith Wahrheit, Birgit Hausknecht, Ulla T. Schultheiß, Wolfram Gronwald, Pascal Schlosser, Sara Tucci, Arif Bülent Ekici et al. · 2018 · Journal of the American Society of Nephrology
- Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization studySaranya Palaniswamy, Dipender Gill, N. Maneka De Silva, Estelle Lowry, Jari J. Jokelainen, Toni Karhu, Shivaprakash Jagalur Mutt, Abbas Dehghan, Eeva Sliz, Daniel I. Chasman et al. · 2020 · American Journal of Clinical Nutrition
- Human FcR Polymorphism and DiseaseXinrui Li, Andrew Gibson, Robert P. Kimberly · 2014 · Current topics in microbiology and immunology
- Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and geneticsTuulia Tynkkynen, Qin Wang, Jussi Ekholm, Olga Anufrieva, Pauli Ohukainen, Jouko Vepsäläinen, Minna Männikkö, Sirkka M Keinanen-Kiukaanniemi, Michael Vaclav Holmes, Matthew Goodwin et al. · 2018 · International Journal of Epidemiology
- Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibitionKettunen, Johannes, Holmes, Michael V., Allara, Elias, Anufrieva, Olga, Ohukainen, Pauli, Oliver-Williams, Clare, Wang, Qin, Tillin, Therese, Hughes, Alun D., Kähönen, Mika et al. · 2019 · PLOS Biology
- Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole BloodRalph Burkhardt, Holger Kirsten, Frank Beutner, Lesca Miriam Holdt, Arnd Gross, Andrej Teren, Anke Tönjes, Susen Becker, Knut Krohn, Peter Louis Kovacs et al. · 2015 · PLoS Genetics
- Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicitiesMuhammad Sajid Hamid Akash, Azka Yaqoob, Kanwal Rehman, Muhammad Imran, Mohammed A. Assiri, Fatema Al‐Rashed, Fahd Al‐Mulla, Rasheed Ahmad, Sardar T. A. K. Sindhu · 2023 · Frontiers in Molecular Biosciences
- Carotid Intima-Media ThicknessRona J. Strawbridge, Joey Ward, Mark E.S. Bailey, Breda Cullen, Amy Ferguson, Nicholas Graham, Keira J.A. Johnston, Laura M. Lyall, Robert Pearsall, Jill P. Pell et al. · 2019 · Arteriosclerosis Thrombosis and Vascular Biology
- Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasmaMark D. Benson, Aaron S. Eisman, Usman A. Tahir, Daniel H. Katz, Shuliang Deng, Debby Ngo, Jeremy Robbins, Alissa Hofmann, Xu Dong Shi, Shuning Zheng et al. · 2023 · Cell Metabolism
- RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinationsToomas Haller, Mart Kals, Tõnu Esko, Reedik Mägi, Krista Fischer · 2013 · Briefings in Bioinformatics
- Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challengeIsabel Bondia‐Pons, Johanna Maukonen, Ismo Matias Mattila, Aila Rissanen, Maria Saarela, Jaakko A. Kaprio, Antti Hakkarainen, Jesper Lundbom, Nina M I Lundbom, Tuulia Hyötyläinen et al. · 2014 · The FASEB Journal
- Variation at 2q35 (PNKDandTMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel diseaseGiulia Orlando, Philip Law, Kimmo Palin, Sari Tuupanen, Alexandra E. Gylfe, Ulrika A. Hänninen, Tatiana Cajuso, Tomas J. Tanskanen, Johanna Kondelin, Eevi Kaasinen et al. · 2016 · Human Molecular Genetics
- Metabolomics: Bridging the Gap between Pharmaceutical Development and Population HealthVladimir Tolstikov · 2016 · Metabolites
- SECIMTools: a suite of metabolomics data analysis toolsAlexander Kirpich, Miguel Ibarra, Oleksandr V. Moskalenko, Justin M. Fear, Joseph Gerken, Xinlei Mi, Ali Ashrafi, Alison M. Morse, Lauren M. McIntyre · 2018 · BMC Bioinformatics