Genome-wide association study identifies multiple loci influencing human serum metabolite levels

Kettunen, Johannes, Tukiainen, Taru, Sarin, Antti-Pekka, Ortega-Alonso, Alfredo, Tikkanen, Emmi, Lyytikäinen, Leo-Pekka, Kangas, Antti J, Soininen, Pasi +23 more·2012·Nature Genetics
DOI 10.1038/ng.1073

Cited by (557)

Items 501–557 of 557

  1. Quantitative Quantum Mechanical Analysis of 1 H NMR Spectra
    Mika Tiainen · 2013
  2. Investigating the genetics Of thyroid stimulating hormone in newborns
    Farah Yacoub Alul, Jeffrey Clark Murray, John M. Dagle, Josep M. Comeron, Alexander G. Bassuk, Terry A. Braun · 2013
  3. Translating Genetic Association Signals for Diabetes and Metabolic Traits into Molecular Mechanisms for Disease
    Matthew G. Rees, Anna L. Gloyn · 2014 · Frontiers in diabetes
  4. Detection of Genes Influencing Chronic and Mendelian Disease via Loss-Of-Function Variation
    Alexander H. Li · 2015 · Digital Commons-TMC (Texas Medical Center)
  5. Application of Systems Biology Analysis to Hepatic Injury Following Hemorrhagic Shock
    Charles E. Determan · 2014 · University of Minnesota Digital Conservancy (University of Minnesota)
  6. Metabolomics and Cardiovascular Medicine
    Waqas Qureshi, David M. Herrington · 2015 · Elsevier eBooks
  7. Translational renal genetics
    Anna Reznichenko · 2012
  8. Genetics of Abdominal Obesity
    Min Xu, Lu Qi · 2014 · Elsevier eBooks
  9. Gene and Metabolic Environment Interactions in Obesity and Diabetes
    Jun Liang, Fei Teng · 2014
  10. Association and interplay of genetic and epigenetic variants in smoking behavior
    Richa Gupta · 2018 · Työväentutkimus Vuosikirja
  11. Applications of Metabolic Phenotyping in Epidemiology
    Rui Climaco Pinto, İbrahim Karaman, Julia C. Fussell, Εvangelos Εvangelou, Frank J. Kelly, Paul Elliott, Ioanna Tzoulaki · 2018 · Elsevier eBooks
  12. Analysis and Visualisation of Very-Long-Duration Acoustic Recordings of the Natural Environment
    Yvonne F Phillips · 2018 · Queensland University of Technology
  13. The role of invariant Natural Killer T cells in SLE patients with atherosclerosis
    Edward C. Smith · 2016 · UCL Discovery (University College London)
  14. Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics
    Azam Yazdani, Akram Yazdani, Sarah H. Elsea, Daniel J. Schaid, Michael R. Kosorok, Gita Dangol, Ahmad Samiei · 2019 · arXiv (Cornell University)
  15. Identification of biomarkers for diabetic retinopathy
    Ward Fickweiler · 2019
  16. Badania surowicy krwi techniką 1H NMR : podstawowe procedury pomiarowe
    Mateusz Ciszek, Łukasz Boguszewicz, Maria B. Sokol · 2017 · Inżynier i Fizyk Medyczny
  17. Identification of Regulatory Elements and Functional Variants at GWAS Loci For Human Metabolic Traits
    Tamara S. Roman · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  18. Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos
    Lourdes Ella G. Santos, Jose B. Nevado, Eva Maria C. Cutiongco – de la Paz, Lauro L. Abrahan, Aimee Yvonne Criselle L. Aman, Elmer Jasper B. Llanes, Jose Donato A. Magno, Deborah Ignacia D. Ona, Felix Eduardo R. Punzalan, Paul Ferdinand M. Reganit et al. · 2021 · Acta Medica Philippina
  19. Omics: Potential Role in Early Phase Drug Development
    Harald Grallert, Carola Marzi, Stefanie M. Hauck, Christian Gieger · 2019 · Springer eBooks
  20. Percepción sobre actividades de enfermería para satisfacción de necesidades familiares en cuidado intensivo adulto
    Edinson Fabian Ardila Suárez, Diego Alejandro Salazar Blandón · 2021 · Investigación en Enfermería Imagen y Desarrollo
  21. Faculty Opinions recommendation of Exome sequencing of Finnish isolates enhances rare-variant association power.
    Fowzan Sami Alkuraya · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  22. Fatty Acids and Cardiometabolic Health
    Jason H. Y. Wu, Matti Marklund · 2019 · MDPI eBooks
  23. Multiomics Approaches in Psychiatric Disorders
    Eva Christina Schulte, Mojtaba Oraki Kohshour, Anna Tkachev, Philipp Khaitovich, Thomas G. Schulze · 2023 · Springer eBooks
  24. Metabolic medicine: The mechanism of metabolic influence on diseases of various systems
    Shusi Ding, Qiutong Wu, Cong Lu, Zhaomeng Wang, Yue Lan, Lu Fang, Lemin Zheng · 2023 · Metabolism and Translational Medicine
  25. Branching-out
    Froukje Vanweert · 2023
  26. Positioning research and Scholarly Innovation within a “transdisciplinary” approacht
    Simeon Davies, Jeanine Lucasta Marnewick, Dirk Jacobus Bester, Oiva Viety Kamati · 2024 · Journal on Innovation and Sustainability RISUS
  27. Additional file 4 of Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study
    Jian Yang, Binbin Zhao, Qian Li, Fengjie Gao, Yanjuan Fan, Xiaoyan He, Qingyan Ma, Lihong Yang, Bin Yan, Wei Wang et al. · 2021 · Figshare
  28. Additional file 1 of Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study
    Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher, Jian‐Gao Fan · 2023 · Figshare
  29. Cardiovascular metabolomics
    Ana Nogal, Panayiotis Louca, Ana Maria Valdes, Sandosh Padmanabhan, Cristina Menni · 2024 · Elsevier eBooks
  30. Multiomics Approaches in Psychiatric Disorders
    Eva Christina Schulte, Mojtaba Oraki Kohshour, Anna Tkachev, Philipp Khaitovich, Thomas G. Schulze · 2024 · Springer eBooks
  31. NMR Data Science
    Jun Kikuchi · 2025 · Springer eBooks
  32. Estimating metabolite networks subject to dietary preferences and lifestyle
    Georgios Bartzis, Carel F.W. Peeters, Hae‐Won Uh, Jeanine J. Houwing‐Duistermaat, Fred A. van Eeuwijk · 2025 · Metabolomics
  33. Functional genes for tail-type traits
    Meng-Hua Li, Hosein Salehian-Dehkordi · 2025 · Elsevier eBooks
  34. Application of Mendelian randomization to explore metabolic pathways in colorectal cancer
    Tung Hoang, Van Mai Truong, Tho Thi Anh Tran · 2025 · Annals of Medicine and Surgery
  35. Additional file 1 of Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study
    Yang, Jian, Zhao, Binbin, Qian, Li, Fengjie Gao, Yanjuan Fan, He, Xiaoyan, Ma, Qingyan, Yang, Lihong, Yan, Bin, Wang, Wei et al. · 2021 · Figshare
  36. Additional file 3 of OsLSC6 Regulates Leaf Sheath Color and Cold Tolerance in Rice Revealed by Metabolite Genome Wide Association Study
    Shuwei Lv, Tang, Xuan, Liqun Jiang, Zhang, Jing, Sun, Bingrui, Liu, Qing, Mao, Xingxue, Yu, Hang, Pingli Chen, Chen, Wenfeng et al. · 2024 · Figshare
  37. Additional file 4 of OsLSC6 Regulates Leaf Sheath Color and Cold Tolerance in Rice Revealed by Metabolite Genome Wide Association Study
    Shuwei Lv, Tang, Xuan, Liqun Jiang, Zhang, Jing, Sun, Bingrui, Liu, Qing, Mao, Xingxue, Yu, Hang, Pingli Chen, Chen, Wenfeng et al. · 2024 · Figshare
  38. Additional file 1 of OsLSC6 Regulates Leaf Sheath Color and Cold Tolerance in Rice Revealed by Metabolite Genome Wide Association Study
    Shuwei Lv, Tang, Xuan, Liqun Jiang, Zhang, Jing, Sun, Bingrui, Liu, Qing, Mao, Xingxue, Yu, Hang, Pingli Chen, Chen, Wenfeng et al. · 2024 · Figshare
  39. Additional file 2 of Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study
    Jian Zhao, Zeng, Jing, Zhu, Cairong, Xuechao Li, Liu, Dong, Jun Zhang, Li, Fei, Giovanni Targher, Jiangao Fan · 2024 · Figshare
  40. Additional file 3 of Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study
    Yang, Jian, Zhao, Binbin, Qian, Li, Fengjie Gao, Yanjuan Fan, Xiaoyan He, Ma, Qingyan, Yang, Lihong, Yan, Bin, Wei Wang et al. · 2021 · Figshare
  41. Additional file 2 of Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study
    Yang, Jian, Zhao, Binbin, Qian, Li, Fengjie Gao, Yanjuan Fan, Xiaoyan He, Ma, Qingyan, Yang, Lihong, Yan, Bin, Wei Wang et al. · 2021 · Figshare
  42. Additional file 1 of Sparse reduced-rank regression for integrating omics data
    Haileab Hilafu, Safo, Sandra E., Lillian Haine · 2020 · Figshare
  43. Additional file 2 of OsLSC6 Regulates Leaf Sheath Color and Cold Tolerance in Rice Revealed by Metabolite Genome Wide Association Study
    Shuwei Lv, Tang, Xuan, Liqun Jiang, Zhang, Jing, Sun, Bingrui, Liu, Qing, Mao, Xingxue, Hang Yu, Pingli Chen, Chen, Wenfeng et al. · 2024 · Figshare
  44. Additional file 5 of OsLSC6 Regulates Leaf Sheath Color and Cold Tolerance in Rice Revealed by Metabolite Genome Wide Association Study
    Shuwei Lv, Tang, Xuan, Liqun Jiang, Zhang, Jing, Sun, Bingrui, Liu, Qing, Mao, Xingxue, Yu, Hang, Pingli Chen, Chen, Wenfeng et al. · 2024 · Figshare
  45. Long-Term Mortality After Tuberculosis Among People With Disabilities in Korea
    Jinsoo Min, So Young Kim, Jong Eun Park, Yeon-Yong Kim, Hee Soo Yang, Bo Hui Park, Seong Woo Jeon, Yu Jin Kim, Bumhee Yang, Kyoung Eun Yeob et al. · 2025 · Journal of Korean Medical Science
  46. Use of Mendelian Randomization to Unveil Metabolic Markers in Helicobacter pylori Infection
    Tung Hoang, Jeongseon Kim · 2025 · Journal of Korean Medical Science
  47. Cord serum metabolic signatures associated with neonatal anthropometry and neurodevelopment through age two in twins
    Liqin Hu, Chenyu Wang, Meng Yang, Miaomiao Zhu, Feiyan Xiang, Lulu Song, Youjie Wang, Hong Mei, Aifen Zhou, Han Xiao · 2026 · iScience
  48. Rôle des aminoacides ramifiés dans le déterminisme génétique de la résistance à l’insuline
    Sara Haydar · 2018 · theses.fr (ABES)
  49. The application of metabolomics by high field nuclear magnetic resonance to study thyroid signalisation pathologies in mice
    Houda Boumaza · 2019 · theses.fr (ABES)
  50. Associations of vegetarianism with circulating lipids across varying genetic capacity: a cross-sectional Polygenic Score-by-Vegetarianism interaction study in UK Biobank
    Angela Ge, Yitang Sun, Alexandra H Chiang, Aryaman Singh, Huifang Xu, Kaixiong Ye · 2026 · medRxiv
  51. Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: a cross-sectional gene-diet interaction study in UK Biobank
    Huifang Xu, Ge Yu, Yueqi Lu, Harriett Fuller, Suhang Song, Ye Shen, Charleston W. K. Chiang, Burcu F. Darst, Kaixiong Ye · 2026 · medRxiv
  52. Exploring the functional role of palmitoylation genes in clear cell renal cell carcinoma and their impact on tumor microenvironment
    Junwu Li, Hai Chang, H M Xu, Yuanyuan Bai, Wei Tang · 2026 · BMC Genomic Data
  53. Foodomics: Recent Trends in Food and Omics
    Rahul Dev, Mahesh Gupta · 2025 · Springer eBooks
  54. Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: A cross-sectional gene–diet interaction study
    Huifang Xu, Ge Yu, Yueqi Lu, Harriett Fuller, Suhang Song, Ye Shen, Charleston W. K. Chiang, Burcu F. Darst, Kaixiong Ye · 2026 · Clinical Nutrition
  55. PLTP Variants rs6065904 and rs378114 Are Associated with Acute Coronary Syndrome Risk and Altered Glucose and Triglyceride Levels in a Mexican Population
    Gilberto Vargas‐Alarcón, Oscar A Pérez-Méndez, Rosalinda Posadas‐Sánchez, Julio Cesar Domínguez-Méndez, Marva Arellano-González, Galileo Escobedo, Teresa Juárez‐Cedillo, José Manuel Fragoso · 2026 · Biomedicines
  56. Nutrigenomics in the prevention and management of type 2 diabetes and obesity: A systematic review of clinical trials
    Ankita S. Mathur, Dhruva Nandi, Anwesha Banerjee, Vini Mehta · 2026 · Nutrition and Health
  57. Circulating metabolites in adolescence associated with clinical obesity in young adulthood
    Shinya Nakada, Ziyi Zhou, Carlos Celis-Morales, Jill P. Pell, Frederick K Ho · 2026 · European Journal of Internal Medicine