The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Open accessAbstract
Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE susceptibility has been established. Recent successes with association studies in SLE have identified genes including IRF5 (refs. 4,5) and FCGR3B. Two tumor necrosis factor (TNF) superfamily members located within intervals showing genetic linkage with SLE are TNFSF4 (also known as OX40L; 1q25), which is expressed on activated antigen-presenting cells (APCs) and vascular endothelial cells, and also its unique receptor, TNFRSF4 (also known as OX40; 1p36), which is primarily expressed on activated CD4+ T cells. TNFSF4 produces a potent co-stimulatory signal for activated CD4+ T cells after engagement of TNFRSF4 (ref. 11). Using both a family-based and a case-control study design, we show that the upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and the TNFSF4 transcript. We hypothesize that increased expression of TNFSF4 predisposes to SLE either by quantitatively augmenting T cell–APC interaction or by influencing the functional consequences of T cell activation via TNFRSF4.
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Cites
The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863
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Cited by
Han, J.-W., Zheng, H.-F., Cui, Y., Sun, L.-D., Ye, D.-Q., Hu, Z., Xu, J.-H., Cai, Z.-M., Huang, W., Zhao, G.-P., et al. (2009) · Nature Genetics · doi:10.1038/ng.472 · Cited by 936
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Genetic susceptibility to systemic lupus erythematosus in the genomic era
Deng, Y., & Tsao, B. P. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.176 · Cited by 379
OX40, OX40L and Autoimmunity: a Comprehensive Review
Webb, G. J., Hirschfield, G. M., & Lane, P. J. L. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8498-3 · Cited by 277
Twin studies in autoimmune disease: Genetics, gender and environment
Bogdanos, D. P., Smyk, D. S., Rigopoulou, E. I., Mytilinaiou, M. G., Heneghan, M. A., Selmi, C., & Eric Gershwin, M. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.003 · Cited by 271
Metadata
- Authors
- Graham, D. S. C., Graham, R. R., Manku, H., Wong, A. K., Whittaker, J. C., Gaffney, P. M., Moser, K. L., Rioux, J. D., Altshuler, D., Behrens, T. W., & Vyse, T. J.
- Venue
- Nature Genetics
- Published
- 2007-12-02
- Volume
- 40
- Issue
- 1
- Pages
- 83-89
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1979689648
- Cited by
- 222
- References
- 1
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. https://app.cochat.ai/papers/10.1038/ng.2007.47
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- Graham, D. S. C., Graham, R. R., Manku, H., Wong, A. K., Whittaker, J. C., Gaffney, P. M., Moser, K. L., Rioux, J. D., Altshuler, D., Behrens, T. W., & Vyse, T. J. (2008). Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nature Genetics. https://doi.org/10.1038/ng.2007.47
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