Cited by 487BRCA gene mutations in cancerGenetic Associations and EpidemiologyBreast Lesions and Carcinomas

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The emerging landscape of breast cancer susceptibility

Stratton, Michael R, Rahman, Nazneen·2008·Nature Genetics

DOI 10.1038/ng.2007.53

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Abstract

The genetic basis of inherited predisposition to breast cancer has been assiduously investigated for the past two decades and has been the subject of several recent discoveries. Three reasonably well-defined classes of breast cancer susceptibility alleles with different levels of risk and prevalence in the population have become apparent: rare high-penetrance alleles, rare moderate-penetrance alleles and common low-penetrance alleles. The contribution of each component to breast cancer predisposition is still to be fully explored, as are the phenotypic characteristics of the cancers associated with them, the ways in which they interact, much of their biology and their clinical utility. These recent advances herald a new chapter in the exploration of susceptibility to breast cancer and are likely to provide insights relevant to other common, heterogeneous diseases.

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Authors: Stratton, M. R., & Rahman, N.
Affiliations: Institute of Cancer Research (GB)
ORCID: Stratton, Michael R
Rahman, Nazneen
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2007-12-27
Volume: 40
Issue: 1
Pages: 17-22
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng.2007.53
OpenAlex: W2067993067
Cited by: 487
References: 56
Citations by year: 2026: 5 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 17 · 2021: 28 · 2020: 20 · 2019: 25 · 2018: 28 · 2017: 25 · 2016: 32 · 2015: 33 · 2014: 32 · 2013: 46 · 2012: 32
FWCI: 17.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
Keywords: breast cancer susceptibility, genetic susceptibility, low-penetrance alleles, cancer risk, genetic heterogeneity
MeSH terms: Alleles, Breast Neoplasms, Female, Humans, Mutation, Penetrance, Genetic Predisposition to Disease

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The emerging landscape of breast cancer susceptibility

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