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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Open accessAbstract
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−4 − 1 × 10−5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10−5, P = 4 × 10−4 and P = 4 × 10−4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
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Cited by
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
BIRAC Consortium, Stahl, E. A., YEAR Consortium, Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., Li, Y., Kurreeman, F. A. S., et al. (2010) · Nature Genetics · doi:10.1038/ng.582 · Cited by 1,253
Self-citationThe Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550
Gregersen, P. K., Amos, C. I., Lee, A. T., Lu, Y., Remmers, E. F., Kastner, D. L., Seldin, M. F., Criswell, L. A., Plenge, R. M., Holers, V. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.395 · Cited by 332
Metadata
- Authors
- Wellcome Trust Case Control Consortium, Barton, A., YEAR Consortium, BIRAC Consortium, Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., Plant, D., Gibbons, L. J., Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., Harrison, P., & Worthington, J.
- Venue
- Nature Genetics
- Published
- 2008-09-14
- Volume
- 40
- Issue
- 10
- Pages
- 1156-1159
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1983142005
- Cited by
- 160
- References
- 0
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Wellcome Trust Case Control Consortium, Barton, A., YEAR Consortium, BIRAC Consortium, Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., Plant, D., Gibbons, L. J., Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., . . . Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics. https://doi.org/10.1038/ng.218
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