The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
Open accessAbstract
We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the REL locus, encoding c-Rel, on chromosome 2p13 (rs13031237, P = 6.01 × 10−10). Replication in independent case-control datasets comprising 2,604 cases and 2,882 controls confirmed this association, yielding an allelic OR = 1.25 (P = 3.08 × 10−14) for marker rs13031237 and an allelic OR = 1.21 (P = 2.60 × 10−11) for marker rs13017599 in the combined dataset. The combined dataset also provides definitive support for associations at both CTLA4 (rs231735; OR = 0.85; P = 6.25 × 10−9) and BLK (rs2736340; OR = 1.19; P = 5.69 × 10−9). c-Rel is an NF-κB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.
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Revised Criteria for the Classification of Rheumatoid Arthritis
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Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX
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Self-citationTRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Plenge, R. M., Seielstad, M., Padyukov, L., Lee, A. T., Remmers, E. F., Ding, B., Liew, A., Khalili, H., Chandrasekaran, A., Davies, L. R. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073491 · Cited by 823
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Self-citationTwo independent alleles at 6q23 associated with risk of rheumatoid arthritis
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Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
Yazar, S., Alquicira-Hernandez, J., Wing, K., Senabouth, A., Gordon, M. G., Andersen, S., Lu, Q., Rowson, A., Taylor, T. R. P., Clarke, L., et al. (2022) · Science · doi:10.1126/science.abf3041 · Cited by 682
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Metadata
- Authors
- Gregersen, P. K., Amos, C. I., Lee, A. T., Lu, Y., Remmers, E. F., Kastner, D. L., Seldin, M. F., Criswell, L. A., Plenge, R. M., Holers, V. M., Mikuls, T. R., Sokka, T., Moreland, L. W., Bridges, S. L., Xie, G., Begovich, A. B., & Siminovitch, K. A.
- Venue
- Nature Genetics
- Published
- 2009-06-07
- Volume
- 41
- Issue
- 7
- Pages
- 820-823
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2026615227
- Cited by
- 332
- References
- 29
- FWCI
- 27.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Gregersen, P. K., Amos, C. I., Lee, A. T., Lu, Y., Remmers, E. F., Kastner, D. L., Seldin, M. F., Criswell, L. A., Plenge, R. M., Holers, V. M., Mikuls, T. R., Sokka, T., Moreland, L. W., Bridges, S. L., Xie, G., Begovich, A. B., & Siminovitch, K. A. (2009). REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics. https://doi.org/10.1038/ng.395
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