The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Pediatric Cancer Genome Project
Open accessAbstract
The St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project (PCGP) is participating in the international effort to identify somatic mutations that drive cancer. These cancer genome sequencing efforts will not only yield an unparalleled view of the altered signaling pathways in cancer but should also identify new targets against which novel therapeutics can be developed. Although these projects are still deep in the phase of generating primary DNA sequence data, important results are emerging and valuable community resources are being generated that should catalyze future cancer research. We describe here the rationale for conducting the PCGP, present some of the early results of this project and discuss the major lessons learned and how these will affect the application of genomic sequencing in the clinic.
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Cites
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A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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An Integrated Genomic Analysis of Human Glioblastoma Multiforme
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Distant metastasis occurs late during the genetic evolution of pancreatic cancer
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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
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Self-citationThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317
Cited by
Mutational landscape and significance across 12 major cancer types
Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419
Self-citationThe landscape of genomic alterations across childhood cancers
ICGC PedBrain-Seq Project, Gröbner, S. N., ICGC MMML-Seq Project, Worst, B. C., Weischenfeldt, J., Buchhalter, I., Kleinheinz, K., Rudneva, V. A., Johann, P. D., Balasubramanian, G. P., et al. (2018) · Nature · doi:10.1038/nature25480 · Cited by 1,572
Self-citationPan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
Ma, X., Liu, Y., Liu, Y., Alexandrov, L. B., Edmonson, M. N., Gawad, C., Zhou, X., Li, Y., Rusch, M. C., Easton, J., et al. (2018) · Nature · doi:10.1038/nature25795 · Cited by 901
Self-citationRecurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma
Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.003 · Cited by 752
Self-citationPaediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
Sturm, D., Bender, S., Jones, D. T. W., Lichter, P., Grill, J., Becher, O., Hawkins, C., Majewski, J., Jones, C., Costello, J. F., et al. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3655 · Cited by 555
Metadata
- Authors
- Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C.-H., Ding, L., Ley, T. J., & Evans, W. E.
- Venue
- Nature Genetics
- Published
- 2012-05-29
- Volume
- 44
- Issue
- 6
- Pages
- 619-622
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1973751980
- Cited by
- 377
- References
- 9
- FWCI
- 27.78
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Pediatric Cancer Genome Project. https://app.cochat.ai/papers/10.1038/ng.2287
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- Downing, J. R., Wilson, R. K., Zhang, J., Mardis, E. R., Pui, C.-H., Ding, L., Ley, T. J., & Evans, W. E. (2012). The Pediatric Cancer Genome Project. Nature Genetics. https://doi.org/10.1038/ng.2287
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