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Cited by 546

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

A heterozygous moth genome provides insights into herbivory and detoxification

Open access
You, Minsheng, Yue, Zhen, He, Weiyi, Yang, Xinhua, Yang, Guang, Xie, Miao, Zhan, Dongliang, Baxter, Simon W, Vasseur, Liette, Gurr, Geoff M, Douglas, Carl J, Bai, Jianlin, Wang, Ping, Cui, Kai, Huang, Shiguo, Li, Xianchun, Zhou, Qing, Wu, Zhangyan, Chen, Qilin, Liu, Chunhui, Wang, Bo, Li, Xiaojing, Xu, Xiufeng, Lu, Changxin, Hu, Min, Davey, John W, Smith, Sandy M, Chen, Mingshun, Xia, Xiaofeng, Tang, Weiqi, Ke, Fushi, Zheng, Dandan, Hu, Yulan, Song, Fengqin, You, Yanchun, Ma, Xiaoli, Peng, Lu, Zheng, Yunkai, Liang, Yong, Chen, Yaqiong, Yu, Liying, Zhang, Younan, Liu, Yuanyuan, Li, Guoqing, Fang, Lin, Li, Jingxiang, Zhou, Xin, Luo, Yadan, Gou, Caiyun, Wang, Junyi, Wang, Jian, Yang, Huanming, Wang, Jun·2013·Nature Genetics
DOI 10.1038/ng.2524
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Abstract

Minsheng You and colleagues report the whole-genome sequence of the diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic and phylogenetic analysis, provides insights into herbivore evolution and insect adaptation to plant feeding and detoxification. How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants1, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood2. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.

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Metadata

Authors
You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S. W., Vasseur, L., Gurr, G. M., Douglas, C. J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., Liu, C., Wang, B., Li, X., Xu, X., Lu, C., Hu, M., Davey, J. W., Smith, S. M., Chen, M., Xia, X., Tang, W., Ke, F., Zheng, D., Hu, Y., Song, F., You, Y., Ma, X., Peng, L., Zheng, Y., Liang, Y., Chen, Y., Yu, L., Zhang, Y., Liu, Y., Li, G., Fang, L., Li, J., Zhou, X., Luo, Y., Gou, C., Wang, J., Wang, J., Yang, H., & Wang, J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-01-13
Volume
45
Issue
2
Pages
220-225
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2524
OpenAlex
W2119258755
Cited by
546
References
10
FWCI
22.05
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: A heterozygous moth genome provides insights into herbivory and detoxification. https://app.cochat.ai/papers/10.1038/ng.2524
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You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S. W., Vasseur, L., Gurr, G. M., Douglas, C. J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., . . . Wang, J. (2013). A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics. https://doi.org/10.1038/ng.2524

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