Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, Sonja I, Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F, Justice, Anne E, Monda, Keri L +314 more·2013·Nature Genetics

Cited by (651)

Items 501–600 of 651

  1. Genetics of Central Obesity and Body Fat
    Yoriko Heianza, L. Qi · 2019 · Nutrition in the Prevention and Treatment of Abdominal Obesity
  2. A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits
    Jennifer L. Asimit, Kalliope Panoutsopoulou, Eleanor Wheeler, Sonja I. Berndt, Heather Jane Cordell, Andrew P. Morris, Eleftheria Zeggini, Inês Barroso · 2015 · Genetic Epidemiology
  3. Association of genetic risk scores with body mass index in Swiss psychiatric cohorts
    Núria Saigí-Morgui, Frederik Vandenberghe, Aurélie Delacrétaz, Lina Quteineh, Mehdi Gholam‐Rezaee, Jean‐Michel Aubry, Armin von Gunten, Zoltán Kutalik, Philippe Conus, Chin B. Eap · 2016 · Pharmacogenetics and Genomics
  4. Joint association analysis of a binary and a quantitative trait in family samples
    Shuai Wang, James B. Meigs, Josée Dupuis · 2016 · European Journal of Human Genetics
  5. Pharmacogenomics of Blood Lipid Regulation
    Marc‐André Legault, Jean‐Claude Tardif, Marie‐Pierre Dubé · 2018 · Pharmacogenomics
  6. Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population
    Gulnara Svyatova, Riza Boranbayeva, Galina Berezina, Lyazat Manzhuova, Alexandra Murtazaliyeva · 2023 · Asian Pacific Journal of Cancer Prevention
  7. Peptide-based GIP receptor inhibition exhibits modest metabolic changes in mice when administered either alone or combined with GLP-1 agonism
    Jason A. West, Soumitra S. Ghosh, David G. Parkes, Anastasia Tsakmaki, Rikke Veggerby Grønlund, Philip J. Pedersen, DAVID G. MAGGS, Harith Rajagopalan, Gavin A. Bewick · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  8. GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders
    Minyu Chan, Satoshi Ogawa · 2025 · Molecular Neurobiology
  9. Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization
    Chenke Jiang, Yihong Gan, Shengyu Chen, Jie Yao, Yilin Zhang, Yongsheng Fan, Xinchang Wang, Li Xu · 2025 · Aging Clinical and Experimental Research
  10. Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty
    Fan Yang, Mengjuan Xue, Xu Han, Ouyang Li, Dayoung Kim, Bin Lu, Zhijun Bao · 2025 · Aging Clinical and Experimental Research
  11. Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis
    Zhijun Feng, Jiacheng Li, Huimin Zhang, Shupeng Liu, Yinghui Wang, Meijuan Zhou, Zhenhua Ding, Lin Xiao · 2025 · Scientific Reports
  12. Choosing sweeteners wisely—nutrigenetic study on childhood obesity
    D. Qiu, Chia-Min Kuo, Shih‐Yuan Hsu, Emily Chia‐Yu Su, San‐Yuan Wang, Jia‐Woei Hou, Meng‐Che Tsai, Chen Yang, Yang‐Ching Chen · 2025 · Nutrition & Metabolism
  13. Circulating Exosomal MicroRNA Profiles Associated with Heavy Metal Exposure and Short Stature in Children
    Min Won Shin, Heeji Kim, Seongho Ryu, Shin-Hye Kim · 2026 · International Journal of Molecular Sciences
  14. Childhood obesity and cardiac risk in youth: Emerging challenges toward 2050
    Nikunja Kishor Mishra · 2026 · Clinical Nutrition ESPEN
  15. Candidate genes related to acute cerebral circulatory disorders in Preeclampsia in the Kazakh Population
    Gulnara Svyatova, Dinara Mirzakhmetova, Galina Berezina, Alexandra Murtazaliyeva · 2023 · Journal of Stroke and Cerebrovascular Diseases
  16. Integrated analyses of genomic and transcriptomic data reveal candidate variants associated with carcass traits in Huaxi cattle
    Yapeng Zhang, Wentao Cai, Qi Zhang, Qian Li, Yahui Wang, Ruiqi Peng, Haiqi Yin, Xin Hu, Zezhao Wang, Bo Zhu et al. · 2024 · Journal of Integrative Agriculture
  17. Reduced Mn uptake of pleiotropic ZIP8 SNP is caused by its loss of Mn-responsive accumulation on the cell-surface
    Yukina Nishito, Hitomi Fujishiro, Shino Nagamatsu, Taiho Kambe · 2024 · Bioscience Biotechnology and Biochemistry
  18. Considerations on efforts needed to improve our understanding of the genetics of obesity
    Sujoy Ghosh, Claude Bouchard · 2024 · International Journal of Obesity
  19. Mendelian randomization unraveled: gender-specific insights into obesity-related phenotypes and colorectal cancer susceptibility
    Xinyi Chen, Mu Yang, Weiheng Zhao, Jingyao Tu, Qingxu Liu, Xianglin Yuan · 2024 · Frontiers in Endocrinology
  20. Relationship between serum vitamin C and serum uric acid in people with different BMIs: results from the NHANES 2017–2018 and Mendelian randomization study
    Jiajie Zhang, Hejun Jiang, Guanghui Fu, Zou Wu, Yukai Yao, Jie Sun · 2024 · Frontiers in Nutrition
  21. Effect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study
    Hang Li, Guangjiao Yin, Yanfang Zhang, Ziwei Wang, Fang Lv, Rui Li, Juanjuan Qin, Xujun Ye · 2025 · Frontiers in Endocrinology
  22. Distinct Co-methylation Patterns in African and European Populations and Their Genetic Associations
    Zheng Dong, Nicole Gladish, Maggie P. Fu, Samantha L. Schaffner, Keegan D. Korthauer, Michael Steffen Kobor · 2025 · Genomics Proteomics & Bioinformatics
  23. The Feasibility of WGS Association Studies for Complex Traits
    Xiaoyi Gao · 2014 · Journal of Next Generation Sequencing & Applications
  24. Obstructive Sleep Apnea
    Susan S Redline · 2016 · Elsevier eBooks
  25. A GWAS follow‐up of obesity‐related SNPs in SYPL2 reveals sex‐specific association with hip circumference
    Juan de Toro‐Martín, Frédéric Guénard, André Tchernof, Yves Deshaies, Louis Përusse, S. Biron, Odette Lescelleur, Laurent D. Biertho, Simon Marceau, Marie‐Claude Vohl · 2016 · Obesity Science & Practice
  26. A Penalized Regression Approach for Integrative Analysis in Gen ome- Wide Association Studies
    Fan Wang · 2015 · Journal of Biometrics & Biostatistics
  27. Genetic architecture of human thinness compared to severe obesity
    Fernando Riveros-Mckay, Mistry V, Bounds R, Audrey E. Hendricks, Keogh JM, Thomas H, Elana Henning, Laura J. Corbin, Society Scientific Group Understanding, Stephen O’Rahilly et al. · 2019 · Yearbook of pediatric endocrinology
  28. 48th European Mathematical Genetics Meeting (EMGM) 2020
    Zoltán Kutalik · 2019 · Human Heredity
  29. microRNAs in Obesity and Metabolic Diseases
    Giuseppe Iacomino, Fabio Lauria, Antonella Venezia, Nunzia Iannaccone, Paola Russo, Alfonso Siani · 2020 · Springer eBooks
  30. The Role of Natural Selection in the Formation of the Genetic Structure of Populations by SNP Markers in Association with Body Mass Index and Obesity
    Ekaterina A. Trifonova, А. А. Попович, А. В. Бочарова, К. В. Вагайцева, В. А. Степанов · 2020 · Molecular Biology
  31. A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity
    Sabine Julia Maria Sag, Stephanie Mueller, Stefan Wallner, Christina Strack, Ute Hubauer, Margareta Mohr, Judith Zeller, Thomas Horst Loew, Michael Rehli, Julia Wimmer et al. · 2023 · Medicine
  32. Epigenetics of Human Obesity: A Link Between Genetics and Nutrition
    David Albuquerque, Licínio Manco, Clévio Nóbrega · 2014 · Springer eBooks
  33. Genome-Wide Association Studies of Obesity
    Åsa K. Hedman, Cecilia M. Lindgren, Mark I. McCarthy · 2013 · Springer eBooks
  34. Whole Genome Interpretation for a Family of Five
    Manuel Corpas, Karyn Mégy, Vanisha Mistry, Antonio Metastasio, Edmund Lehmann · 2021 · Frontiers in Genetics
  35. Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects
    Arkan Abadi, A. Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, J. Engert, H. Gerstein, S. Anand et al. · 2017 · bioRxiv
  36. Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data
    Mark J. Adams, David M. Howard, Michelle Luciano A, Toni‐Kim Clarke, Gail Davies, William David Hill, Daniel J. Smıth, Ian J. Deary, David John Porteous, Andrew Mark McIntosh · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Dataset of allele and genotype frequencies of five polymorphisms candidate genes analyzed for association with body mass index in Russian women
    Решетников Евгений Александрович, Maria Yu. Abramova, Irina Ponomarenko, Alexey Polonikov, Верзилина Ирина Николаевна, Сорокина Инна Николаевна, Inna Aristova, Anna Yermachenko, Volodymyr Dvornyk, Mikhail Ivanovich Churnosov · 2019 · Data in Brief
  38. Genome-wide scale analyses identify novel BMI genotype-environment interactions using a conditional false discovery rate
    Rachel Moore, L. Georgatou-Politou, James Liley, Oliver Stegle, Inês Barroso · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex Traits
    Michael C. Turchin, Gregory Darnell, Lorin A. Crawford, Sohini Ramachandran · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  40. WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE
    Xinruo Zhang, Jennifer A. Brody, Mariaelisa Graff, Heather M. Highland, Nathalie Chami, Hanfei Xu, Zhe Wang, Kendra Ferrier, Geetha Chittoor, Navya Shilpa Josyula et al. · 2023 · medRxiv
  41. Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy
    Todd Hulgan, Kristine Mace Erlandson, Yuki Bradford, Katherine Tassiopoulos, Kunling Wu, Sara Hurtado Bares, Todd Tarquin Brown, Jordan E. Lake, Michael A. Leonard, Grace A. McComsey et al. · 2025 · Open Forum Infectious Diseases
  42. Design and therapeutic rationale of antibody-peptide conjugates: insights from maridebart cafraglutide (AMG133) and emerging applications
    Junming Yie, Zongchun Mou, Xiaohong Liu · 2026 · Antibody Therapeutics
  43. The first genome-wide association study on pediatric obesity in Taiwan.
    Hsin-Ru Wu, Ting-Yuan Liu, Chuan-Mu Chen, Fuu-Jen Tsai · 2026 · Journal of the Formosan Medical Association = Taiwan yi zhi
  44. Association Studies with Imputed Variants Using Expectation-Maximization Likelihood-Ratio Tests
    Kuan-Chieh Huang, Wei Sun, Ying Wu, Mengjie Chen, Karen L. Mohlke, Leslie A. Lange, Yun Li · 2014 · PLoS ONE
  45. How Fatty Acids and Common Genetic Variants Together Affect the Inflammation of Adipose Tissue
    Kenna Slim, Anne Marie Minihane · 2014 · Current Cardiovascular Risk Reports
  46. Rare Genetic Diseases with Human Lean and/or Starvation Phenotype Open New Avenues for Obesity and Type II Diabetes Treatment
    Itzik Harosh · 2014 · Current Pharmaceutical Biotechnology
  47. Role of Conventional Risk Factors in Genetic Susceptibility to Cardiovascular Diseases
    Daniel I. Swerdlow, Michael Michail, Konstantinos A. Zacharias · 2016 · Elsevier eBooks
  48. An efficient algorithm for generating the internal branches of a Kingman coalescent
    Mark Reppell, Sebastian K. Zöllner · 2017 · Theoretical Population Biology
  49. Global Landscapes of Human Phenotypic Variation in Inherited Traits
    Ryosuke Kimura · 2017 · Evolutionary studies
  50. Triplet Male Lambs Are More Susceptible than Twins to Dietary Soybean Oil–Induced Fatty Liver
    Bo Wang, Yanghua Qu, Yiping Wang, Yong Ma, Chenchen Xu, Fadi Li, Ce Liu, Xiaonan Lu, Bo Wang, Peng Xiu et al. · 2019 · Journal of Nutrition
  51. Measurement Possibilities of Thoracic (C7-T12) and Lumbar (L1-L5) Curvature
    S Surya, Dinesh Shanmugam, Murali Subramaniyam · 2020 · IOP Conference Series Materials Science and Engineering
  52. Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study
    Adam J. Santanasto, Mary K. Wojczynski, Ryan Cvejkus, Shiow J. Lin, Lihua Wang, Bharat Thyagarajan, Kaare Christensen, Nicole Schupf, Mary Furlan Feitosa, Ping An et al. · 2021 · The Journals of Gerontology Series A
  53. MicroRNAs as Targets of Dietary Phytochemicals in Obesity and Cancer
    Chukwuebuka Egbuna, Muhammad Akram, Kingsley Chukwuemeka Patrick-Iwuanyanwu, Mehwish Iqbal, Eugene N. Onyeike, Chukwuemelie Zedech Uche, Sadia Hassan · 2021 · Springer eBooks
  54. Genetics of Childhood Obesity
    Struan F.A. Grant · 2013 · Springer eBooks
  55. Faktor Risiko Stunting pada Bayi dan Balita (Anak Usia 0-59 Bulan) di Wonosobo
    Fibrinika Tuta Setiani, Abdullah Azam Mustajab · 2023 · Malahayati Nursing Journal
  56. Elucidation of genetic determinants of dyslipidaemia using a global screening array for the early detection of coronary artery disease
    Ananthaneni Radhika, Sandeepta Burgula, Chandan Badapanda, Tajamul Hussain, S. Naushad · 2023 · Mammalian Genome
  57. Exome-wide comparative analyses revealed differentiating genomic regions for performance traits in Indian native buffaloes
    Vishakha Uttam, Vikas Vohra, Supriya Chhotaray, Ameya Santhosh, Vikas Diwakar, Vaibhav Patel, Rajesh Kumar Gahlyan · 2023 · Animal Biotechnology
  58. Phenome-Wide Association Study
    Jeremy Lyle Warner, Joshua C. Denny · 2015 · Elsevier eBooks
  59. Personalized Dietary SikdanOme Recommendation based on Obesity Related SNP Genotype and Phenotype
    Ga‐Hee Shin, Sang-Min Lee, Byeong-Chul Kang, Dai Ja Jang, Dae Young Kwon, Min-Jung Kim, Ri-Rang Kim, Jin Hee Kim, Hye Jeong Yang · 2016 · The Journal of the Korea Contents Association
  60. Association study between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and metabolic syndrome
    Monique Tremblay, Diane Brisson, Daniel Gaudet · 2018 · BMC Medical Genetics
  61. Genetic Architecture of Human Obesity Traits in the Rhesus Macaque
    Michael J. Raboin, John Letaw, Asia Mitchell, David E. Toffey, Jessica McKelvey, Charles T. Roberts, Joanne E. Curran, Amanda Vinson · 2019 · Obesity
  62. 1 Good Parents and New Reproductive Technologies
    Christopher Gyngell · 2018
  63. Роль естественного отбора в формировании генетической структуры популяций по SNP-маркерам, связанным с индексом массы тела и ожирением
    Ekaterina A. Trifonova, А. А. Попович, А. В. Бочарова, К. В. Вагайцева, В. А. Степанов · 2020 · Molecular Biology
  64. Pinpointing the genetic and cellular links between sleep and metabolism
    Susan T Harbison · 2022 · SLEEP
  65. Exploring molecular links between obesity and breast cancer.
    Rebekah Crake · 2015 · Otago University Research Archive (University of Otago)
  66. Hnf4a mediates microbial control of intestinal gene expression and inflammation
    James M. Davison, Colin R. Lickwar, Lingyun Song, Ghislaı̀n Breton, Gregory E. Crawford, John Franklin Rawls · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Polygenic risk scores based on European GWAS correlate to disease prevalence differences around the world
    Pritesh Jain, Myson Burch, Melanie Martinez, Pablo Mir, Jakub Piotr Fichna, Cezary Żekanowski, Renata Rizzo, Zeynep Tümer, Csaba Barta, Evangelia Yannaki et al. · 2021 · medRxiv
  68. Identification and Characterization of Rare Variants in Cholinergic Nicotinic Receptor Genes and their Contribution to Substance Dependence
    Gabriel Emanuel Haller · 2013 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  69. Genetic and metabolic components in the regulation of serum urate levels in humans
    Eva Albrecht · 2014
  70. The Role of the GWAS Identified FTO Locus in Regulating Body Size and Composition
    Giles S.H. Yeo · 2014 · Springer eBooks
  71. Functional and Molecular Characterization of Centrally Expressed Genes Associated with Obesity
    Anders Eriksson · 2015 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  72. Genetic analysis of protein N-glycosylation
    Jennifer E. Huffman · 2014 · ERA
  73. Genome-Wide Association Studies of Obesity and Related Traits
    Karen L. Mohlke, Cecilia M. Lindgren · 2014 · Frontiers in diabetes
  74. The Genetics of Pediatric
    Obesity Chesi · 2015
  75. Genome-Wide Association Studies (GWAS) of Adiposity
    Erik Ingelsson, Tuomas O. Kilpeläinen · 2016 · Springer eBooks
  76. Nutrigenetics of Type 2 Diabetes
    Lu Qi, Paul W. Franks · 2016 · Springer eBooks
  77. Genome-wide association studies of body mass index
    Tuomas O. Kilpeläinen · 2015 · Cambridge University Press eBooks
  78. Genetic Overlap Between Depression and Cardiometabolic Disorders
    Azmeraw T. Amare, Klaus Oliver Schubert, Bernhard Theodor Baune · 2016 · Springer eBooks
  79. Genetics of Abdominal Obesity
    Min Xu, Lu Qi · 2014 · Elsevier eBooks
  80. A nonsense loss-of-function mutation i PCSK1 contributes to dominantly inherited human obesity
    Julien Philippe, Pieter Stijnen, David Meyre, John W.M. Creemers, Philippe Froguel, Amélie Bonnefond · 2014
  81. Human enhancement and human diversity : the need for a coordinated approach to enhancement technologies
    Christopher Allan Gyngell · 2014 · ANU Open Research (Australian National University)
  82. Estimation of candidate genes in the development of a combination of endometrial hyperplasia and uterine fi broids
    Irina Ponomarenko, Mikhail Ivanovich Churnosov · 2017 · Medical Herald of the South of Russia
  83. Identifying Single-Nucleotide Polymorphisms (SNP) Effective in Face and Scull Identification
    Afshin KHara, Abdullah Sajjadian · 2018 · مجله پزشکی قانونی ایران
  84. ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION
    Tanya A. Baldwin · 2018 · Digital Commons-TMC (Texas Medical Center)
  85. STATISTICAL METHODS FOR GENETIC AND EPIGENETIC ASSOCIATION STUDIES
    Kuan‐Chieh Huang · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  86. Physical activity reduces colorectal cancer risk independent of BMI—A two-sample Mendelian randomisation study
    Xiaomeng Zhang, Evropi Τheodoratou, Xue Li, Susan Mary Farrington, Philip Law, Peter Broderick, Marion Walker, Jessica M. B. Rees, Richard S. Houlston, Ian P.M. Tomlinson et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  87. The impact of the environment on the human (epi)genome: Are we responsible for the epigenetic changes we pass on to our offspring?
    Luigi Bouchard · 2019 · Health Science Inquiry
  88. An In Vivo Screen for Genes Involved in Central Nervous System Control of Obesity Identifies Diacylglycerol Kinase as a Regulator of Insulin Secretion
    Irene Trinh · 2017 · TSpace (University of Toronto)
  89. Population-haplotype models for mapping and tagging structural variation using whole genome sequencing
    Eleni M. Loizidou · 2018 · Spiral (Imperial College London)
  90. The Genetics of Breast Cancer Susceptibility — Polymorphism and the Prospect of their Use in a Clinical Setting Genetique de la susceptibilite au cancer du sein — Polymorphismes et perspectives d’utilisation en clinique
    David G. Cox · 2014
  91. Design and development of an instrument to measure coordinates of spine curvature
    Shreyansh Gharde, Debojit Talukdar, M R Asif, Dinesh Shanmugam, Murali Subramaniyam · 2020 · IOP Conference Series Materials Science and Engineering
  92. The influence of family history, aggravate by essential hypertension and metabolic disorders, on some cardiovascular risk factors in patients with essential hypertension
    В. А. Чернышов, А. О. Nesen · 2020 · Ukrainian Therapeutical Journal
  93. Examining the Role of Socioeconomic Status on Blood Pressure in African Americans
    Brittany M. Hollister · 2017
  94. Evidence for Natural Selection and Ethnic Diversity at the Adenylate cyclase 3 Gene Associated with Obesity and Type 2 Diabetes
    Issei Yoshiuchi · 2020 · Research Square
  95. A review on association and correlation of genetic variants with eating disorders and obesity
    Sayed Koushik Ahamed, Md Abdul Barek, Uthpall Kumar Roy, Mamoona Kouser, Md. Sharif Reza, Afifa Binthe Mannan, Md. Ashraful Alam, Siraj Uddin · 2021 · Future Journal of Pharmaceutical Sciences
  96. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation
    Camelia C. Minică, Michael Churton Neale, Dorret Irene Boomsma, Jenny van Dongen · 2021 · Elsevier eBooks
  97. Regional disparities in the prevalence and incidence of type 2 diabetes mellitus and associated risk factors in Germany: Results from DIAB CORE
    Sabine Schipf · 2014
  98. Characterization of adiposity and inflammation genetic pleiotropy underlying cardiovascular risk factors in Hispanics.
    Mohammad Yaser · 2020
  99. 思想的飞刀:是百无一用还是百发百中——读《影响世界历史的100名著排行榜》
    孔庆典 · 2006 · 民主与科学
  100. Mind the gatekeeper
    Inês Magro dos Reis · 2022