The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
Open accessAbstract
Prostate cancers remain indolent in the majority of individuals but behave aggressively in a minority. The molecular basis for this clinical heterogeneity remains incompletely understood. Here we characterize a long noncoding RNA termed SChLAP1 (second chromosome locus associated with prostate-1; also called LINC00913) that is overexpressed in a subset of prostate cancers. SChLAP1 levels independently predict poor outcomes, including metastasis and prostate cancer–specific mortality. In vitro and in vivo gain-of-function and loss-of-function experiments indicate that SChLAP1 is critical for cancer cell invasiveness and metastasis. Mechanistically, SChLAP1 antagonizes the genome-wide localization and regulatory functions of the SWI/SNF chromatin-modifying complex. These results suggest that SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex.
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Self-citationThe mutational landscape of lethal castration-resistant prostate cancer
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Cited by
The landscape of long noncoding RNAs in the human transcriptome
Iyer, M. K., Niknafs, Y. S., Malik, R., Singhal, U., Sahu, A., Hosono, Y., Barrette, T. R., Prensner, J. R., Evans, J. R., Zhao, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3192 · Cited by 2,738
Self-citationThe emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Self-citationMechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
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Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J. J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.039 · Cited by 733
“We also identified novel fusions between coding and non-coding genes, exemplified by SCHLAP1, a lncRNA highly enriched in a subset of aggressive prostate cancers (Prensner et al., 2013).”
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Metadata
- Authors
- Prensner, J. R., Iyer, M. K., Sahu, A., Asangani, I. A., Cao, Q., Patel, L., Vergara, I. A., Davicioni, E., Erho, N., Ghadessi, M., Jenkins, R. B., Triche, T. J., Malik, R., Bedenis, R., McGregor, N., Ma, T., Chen, W., Han, S., Jing, X., Cao, X., Wang, X., Chandler, B., Yan, W., Siddiqui, J., Kunju, L. P., Dhanasekaran, S. M., Pienta, K. J., Feng, F. Y., & Chinnaiyan, A. M.
- Venue
- Nature Genetics
- Published
- 2013-09-29
- Volume
- 45
- Issue
- 11
- Pages
- 1392-1398
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1974720903
- Cited by
- 669
- References
- 9
- FWCI
- 17.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Prensner, J. R., Iyer, M. K., Sahu, A., Asangani, I. A., Cao, Q., Patel, L., Vergara, I. A., Davicioni, E., Erho, N., Ghadessi, M., Jenkins, R. B., Triche, T. J., Malik, R., Bedenis, R., McGregor, N., Ma, T., Chen, W., Han, S., Jing, X., . . . Chinnaiyan, A. M. (2013). The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nature Genetics. https://doi.org/10.1038/ng.2771
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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