Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko, Valeriya, Nagorny, Cecilia L F, Erdos, Michael R, Wierup, Nils, Jonsson, Anna, Spégel, Peter, Bugliani, Marco, Saxena, Richa, Fex, Malin, Pulizzi, Nicolo, Isomaa, Bo, Tuomi, Tiinamaija, Nilsson, Peter, Kuusisto, Johanna, Tuomilehto, Jaakko, Boehnke, Michael, Altshuler, David, Sundler, Frank, Eriksson, Johan G, Jackson, Anne U, Laakso, Markku, Marchetti, Piero, Watanabe, Richard M, Mulder, Hindrik, Groop, Leif·2009·Nature Genetics
DOI 10.1038/ng.288
Cited by (745)
Items 601–700 of 745
- Genetic variants affect diurnal glucose levels throughout the dayNasa Sinnott-Armstrong, Satu J. Strausz, Lea Urpa, Erik Abner, Josephine P. Johnson, Jesse Tyler Valliere, Teele Palumaa, FinnGen, VA Million Veteran Program, Priit Palta et al. · 2026 · Nature Communications
- Diabetes Mellitus: Exploring Biomarkers, Complications, and Therapeutic Strategies with a Spotlight on Cyanobacterial Bioactive Compounds - A Comprehensive ReviewSuhail Ahmad, Salman Akhtar, Mohammad Amjad Kamal, Alvina Farooqui · 2024 · Current Diabetes Reviews
- Interaction Between Dietary Fiber Intake and MTNR1B rs10830963 Polymorphism on Glycemic Profiles in Young Brazilian AdultsAna Carolina da Silva Lima, Nathália Teixeira Cruvinel, Nara Rubia da Silva, Marcela Moraes Mendes, Amélia Cristina Stival Duarte, Alexandre Siqueira Guedes Coelho, Karani Santhanakrishnan Vimaleswaran, Maria Aderuza Horst · 2025 · Genes
- Prospective Role of N-Acetyl-5-Methoxytryptamine and 5-Hydroxytryptophan in β-Cell Health and Improved Insulin Sensitivity in HyperglycemiaAlok Raghav, Brijesh Kumar Mishra, Renu Tomar, Supriya Raghav, Goo‐Bo Jeong · 2021 · Chronobiology in Medicine
- Morphological differences in the pancreas of normo- and hypertensive rats after joint exposure of intermittent hypoxia and melatoninRoman V. Yanko, Mikhail I. Levashov · 2021 · Journal of the Belarusian State University Biology
- Kinetics of insulin secretion to acute, repetitive stimulation of islets in vivo in sprague dawley ratsJianliang Chen, Aparna Nittala, Shouguo Gao, Soumitra Ghosh, Xujing Wang, Shailendra B. Patel · 2010 · Islets
- Genome-Wide Association Studies and Genotyping TechnologiesKevin V. Shianna · 2010 · Elsevier eBooks
- From Association to Function: MTNR1BAmélie Bonnefond, Valeriya Lyssenko · 2016 · Springer eBooks
- Chronobiology and chrononutrition: Relevance for agingDamiano Galimberti, Giuseppe Mazzola · 2021 · Elsevier eBooks
- Associations of the MTNR1B rs10830963 and PPARG rs1801282 variants with gestational diabetes mellitus: A meta-analysisFujia Chen, Xiaoping Fei, Min Li, Zhaofeng Zhang, Weiqiang Zhu, Min Zhang, Xiaohong Chen, Junzhi Xu, Meihua Zhang, Yupei Shen et al. · 2023 · International Journal of Diabetes in Developing Countries
- Genetics of Type 2 DiabetesStruan F.A. Grant · 2023 · Springer eBooks
- Better understanding and new insight of genetic risk loci for gestational diabetes mellitusNam H. Cho, Hak Chul Jang · 2012 · Journal of Diabetes Investigation
- Commentary: A new dawn for genetic epidemiology?Timothy M. Frayling · 2009 · International Journal of Epidemiology
- Abnormalities of Insulin Secretion and β‐Cell Defects in Type 2 DiabetesStefano Del Prato, Cristina Bianchi, Giuseppe Daniele · 2024 · Wiley eBooks
- The role of melatonin in type 2 diabetes and obesityAgnieszka Przezak, Weronika Bielka, Maciej Arciszewski, Bolesław Banach · 2021 · Farmacja Polska
- Study on Type 2 Diabetes and Sleep Disorders燕 吴 · 2021 · Advances in Clinical Medicine
- Genetic Polymorphisms Associated with the Efficiency of Weight Loss: A Systematic ReviewEmiliya S. Egorova, Ildus I. Ahmetov · 2023 · Генетика
- Diabetes-associated Genetic Variation in MTNR1B and Its Effect on Islet FunctionMax Vella, Sneha Mohan, Hannah E. Christie, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Aleksey V. Matveyenko, Aoife Maria Egan, Adrian V Vella · 2024 · Journal of the Endocrine Society
- Disruption of Melatonin Signaling Leads to Lipids Accumulation in the Liver of Melatonin Proficient MiceVarunika Goyal, Gianluca Tosini · 2024 · Journal of Pineal Research
- Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissuesOzvan Bocher, Ana Luiza Arruda, Satoshi Yoshiji, Chi Zhao, Alicia Huerta‐Chagoya, Chen‐Yang Su, Xianyong Yin, Davis Cammann, Henry J. Taylor, Jingchun Chen et al. · 2026 · Nature Metabolism
- Association of Genetic Polymorphisms with Gestational Diabetes in a Kazakh Population: A Case–Control StudyLaura Danyarova, Gulnara Svyatova, Galina Berezina, Rustem Tuleutayev, Balnur Sultanova, Assel Taigulova, Aigul Sartayeva, Moldir Zhekeyeva, Indira K. Karibayeva · 2026 · Diagnostics
- Association between weekend catch-up sleep and Metabolic dysfunction-associated steatotic liver disease in US adultsJinlong Chen, Wei Wang, Jie He, Xinxin Fang · 2026 · Clinical and Experimental Medicine
- Epigenetics in the Pathophysiology of Type 2 DiabetesCharlotte Ling · 2012 · Elsevier eBooks
- DiabetesJosé C. Florez · 2012 · Elsevier eBooks
- La importancia del reloj biológico en el desarrollo de la obesidad y de la diabetesElaine Cristina Vieira · 2015 · Avances en Diabetología
- Genetics and epigenetics of syntropic diseasesVictoria N. Gorbunova · 2011 · Russian Journal of Genetics Applied Research
- DNA Variations, Impaired Insulin Secretion and Type 2 DiabetesValeriya Lyssenko, Leif Groop · 2011 · Springer eBooks
- The epifamin effect on values of immune status, carbohydrate and lipid metabolism in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitusЗолоедов, Vladimir Ivanovich Zoloedov, Агарков, Aleksander A. Agarkov, Попов, S. Popov, Пашков, А. Н. Пашков, Шульгин, K. K. Shulgin · 2014 · Journal of New Medical Technologies
- UVR protection influences fructosamine level after sun exposure of healthy adultsBeata Mianowska, Joanna Narbutt, Antony Richard Young, Wojciech M Fendler, Beata Małachowska, Wojciech Michal Mlynarski, Aleksandra Lesiak · 2016 · Photodermatology Photoimmunology & Photomedicine
- Effects of TLR4 Variants on Fasting Glucose Levels in a Korean PopulationGi Tae Kim, Jae Woong Sull, Sun Ha Jee · 2017 · Korean Journal of Clinical Laboratory Science
- General regression model: A “model‐free” association test for quantitative traits allowing to test for the underlying genetic modelEmilie Gloaguen, Marie‐Hélène Dizier, Mathilde Boissel, Ghislain Rocheleau, Mickaël Canouil, Philippe Froguel, Jean Tichet, Ronan Roussel, The D.E.S.I.R. Study Group, Cécile Julier et al. · 2019 · Annals of Human Genetics
- A Review on Gestational Diabetes Mellitus: Present ConcernNavjot Kaur, Kuruba Yamini Priyanka, Prabhjot Kaur, Monika Chopra · 2021 · Environment Conservation Journal
- Nutrition, Epigenetics, and Circadian RhythmsDemin Cai, Hao‐Yu Liu, Kaiqi Li, Yanli Zhu · 2024 · Epigenetics and human health
- The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjectsSijie Zhang, Wenxuan Bian, Yan Wang, Min Shen, Yu Qian, Hao Dai, Shuai Zheng, Qi Fu, Kuanfeng Xu, Tao Yang et al. · 2025 · Frontiers in Endocrinology
- Impact of Melatonin on Brain Metabolism in Diabetes: A Narrative ReviewAzubuike Raphael Nwaji, Sunday Agba Bisong, Atim Bassey Antai, Chika Maryjane Okakpu, Miracle Princess Okechukwu, Esther Onyinyechi Igwe, Cynthia Okafor, Precious Chinenye Odoh, Maryjane Chiamaka Chukwu, Joyful Idimmachi Esinulo et al. · 2025 · Natural Product Communications
- Genes and Gene–Environment Interactions in the Pathogenesis of Obesity and the Metabolic SyndromeDespina Sanoudou, Elizabeth Vafiadaki, Christos Socrates Mantzoros · 2009 · Humana Press eBooks
- Decreased Insulin Secretion in Women with Previous Gestational Diabetes MellitusYoon Pyo Lee, Soo Kyung Lim, Ji Young Chang, Eun Kyo Jung, Youn I Choi, Jee Young Oh, Young-Sun Hong, Yeon‐Ah Sung, Hyejin Lee · 2015 · Ewha Medical Journal
- Diabète secondaire aux traitements immunosuppresseurs en transplantation d'organeJulien Zuber, Nicolas Pallet, Ch. Legendre, Danièle Dubois‐Laforgue · 2010 · EMC - Endocrinologie - Nutrition
- Emerging Role of Pancreatic β-Cells during Insulin ResistanceAlpana Mukhuty, Chandrani Fouzder, Snehasis Das, Dipanjan Chattopadhyay · 2019 · IntechOpen eBooks
- Pineal Gland Rhythm and Circadian PhysiologyChetri Ranju · 2021 · International Journal of Current Research and Review
- Circadian Rhythm and ObesityXueting Guan · 2023 · Highlights in Science Engineering and Technology
- Assessment of melatonin level and genetic aspect of type 2 diabetes mellitus patients in Thi-Qar province, IraqKhalid G. Al-Fartosi, Enas Abdul Kareem Jabbar, Ahmed A. Jabbar · 2019 · University of Thi-Qar Journal of Science
- Epigenetics and Type 2 DiabetesCharlotte Ling, Tina Rönn, Marloes Dekker Nitert · 2011 · Springer eBooks
- Epigenetics of Diabetes in HumansCharlotte Ling, Tina Rönn · 2012 · Elsevier eBooks
- The genetics of type 2 diabetesEmma Ahlqvist, Leif Groop · 2015 · Wiley eBooks
- Genetic studies of autism and autistic-like traitsLina Jönsson · 2015 · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Melatonin: the sleeping hormoneVenkata Ranga Rao Kodali · 2016 · International Journal of Diabetes in Developing Countries
- Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestational diabetes mellitus: an updated meta-analysisXiangyuan Yu, Wang Qian-qian, Qin Linyuan, Peng Ling-xiang, Chen Zai-ming, Qin Xiumei, Wang Yuchun, Shi Qingfeng, Yu Hongping · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variantT. Singh, Sebastian Kalamajski, João Gabriel Dantas Cunha, Sergey Hladkou, Fiona Louise Roberts, S. Gheibi, Ali Reza Soltanian, K. Yektay Farahmand, Ola Ekström, Anant Mamidi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Association of climatic determinants with Type 1 and Type 2 Diabetes worldwide: Night length and photoperiod variation linked to T1D and sunshine to T2DJulien Lacouchie · 2024 · medRxiv
- Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With
<i>MTNR1B</i>
Diabetes Risk VariantQian, Jingyi, Stefanovski, Darko, Andersen, Phillip A.K., Vujovic, Nina, Kelly, Lauren, Lepson, Joshua, Nguyen, Hoa, Byrne, Sean, Wang, Wei, Mandrup-Poulsen, Thomas et al. · 2026 · Diabetes Care
- Disruption of circadian rhythm impairs pancreatic islet function and increases susceptibility to beta-cell failure, while pathological complications of Type 2 Diabetes Mellitus have scant effects on the circadian systemJingyi Qian · 2015 · eScholarship (California Digital Library)
- Gene x lifestyle interactions in type 2 diabetes mellitus and related traitsEma C. Brito · 2010 · DiVA at Umeå University (Umeå University)
- Circadian Control of Islet FunctionJeongkyung Lee, Mousumi Moulik, Vijay K. Yechoor · 2014 · Springer eBooks
- Depression, Poor Sleep Quality, and Stress : Associations with Insulin Resistance, Insulin Secretion and the Metabolic Syndrome in Individuals without Type 2 DiabetesAntti-Jussi Pyykkönen · 2012 · Työväentutkimus Vuosikirja
- Translating Advances in Our Understanding of the Genetics of Diabetes into the ClinicDaphne Su-Lyn Gardner, Katharine R. Owen, Anna L. Gloyn · 2014 · Frontiers in diabetes
- Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes MellitusMagnus Ekelund · 2010 · Lund University Publications (Lund University)
- The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetesTina Rönn · 2010 · Lund University Publications (Lund University)
- Novel genetic findings applied to the clinic in type 2 diabetesJosé C. Florez · 2009 · Endocrinología y Nutrición
- Melatonin: An Adjunctive Treatment for Cardiometabolic Disease?Helen J. Burgess · 2012 · SLEEP
- Recent Developments in the Genetic and Genomic Basis of Type 2 DiabetesHannah B. Richards, Mark I. McCarthy · 2012 · Current Cardiovascular Risk Reports
- Translating pharmacogenetics to primary careJesse Joachim Swen · 2011 · Leiden Repository (Leiden University)
- Perfil noturno da síntese de melatonina na glândula pineal de ratos com obesidade hipotalâmica induzida pelo glutamato monossódico.Janaína Barduco Garcia · 2014 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Gene Variants for Obesity and Type 2 Diabetes – A Shared Aetiology?Clara C. Elbers, Marcel G. M. Wolfs, Timon W. van Haeften · 2009 · touchREVIEWS in Endocrinology
- Genome-Wide Association Studies of Glycaemic Traits: A MAGICal JourneyJosé C. Florez, Inês Barroso · 2014 · Frontiers in diabetes
- Voeding en de biologische klokDirk Jan Stenvers, Cora F. Jonkers‐Schuitema, Eric Fliers, Peter H L T Bisschop, Andries Kalsbeek · 2013 · Bohn Stafleu van Loghum eBooks
- "complexes" Collège National des Enseignants et Praticiens de Génétique MédicaleFrancis Vasseur · 2011
- Genome-Wode Association Studies (GWAS) Deliver Big Breakthroughs in Identifying Type 2 Diabetes Susceptibility Genes in the General PopulationWei Cui, Cuilin Zhang, Yiqing Song · 2009 · North American Journal of Medicine and Science
- Genomics of Type 2 Diabetes - ReviewSuparna Deepak, Rosalind Marita · 2015
- Мелатонин при сахарном диабете: от патофизиологии к перспективам леченияVadim Valer'evich Klimontov, Russian Federation · 2013
- Revealing the genetic roots of obesity and type 2 diabetesJana V. van Vliet‐Ostaptchouk · 2010
- Genetic Variants and Risk of DiabetesValeriya Lyssenko · 2016 · Elsevier eBooks
- Genetics of Cardiovascular Disease and Its Role in Risk PredictionKiran Musunuru, Sekar Kathiresan · 2011 · Elsevier eBooks
- Amino Acids Supplementation as Nutritional Therapy Strategy in Diabetes MellitusGiuseppe D’Antona · 2014 · Elsevier eBooks
- Cellular Immunological Mechanisms Contributing to Diabetes PathogenesisMiljana Radenkovic · 2016 · Lund University Publications (Lund University)
- Clock gene variation in type 2 diabetes: a reviewNushrat Parveen, Trilochan Satapathy, Pushpa Prasad, Amit Roy · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
- From THE INSTITUTE OF ENVIRONMENTAL MEDICINE, THE UNIT OF EPIDEMIOLOGY Karolinska Institutet, Stockholm, SwedenLisa Olsson · 2012
- Endoplasmic reticulum calcium dynamics and insulin secretion in pancreatic β cellsWataru R. Yamamoto · 2017 · IUScholarWorks (Indiana University)
- Contribuição dos polimorfismos rs10830963 e rs1387153 no gene da melatonina para ocorrência de diabetes mellitus gestacional e fissuras labiopalatinasLília Maria Von Kostrisch · 2017
- The post-GWAS era: paving the way from association to functional insightStephanie A. Rosse · 2014 · ResearchWorks at the University of Washington (University of Washington)
- Sleep, dietary patterns and metabolic health in UK adultsGregory D. Potter · 2018 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
- O papel da melatonina na regulação do tecido adiposo marromBruno Halpern · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- The Association of Genetic Factors to Multiple Sclerosis SusceptibilityMaryamsadat Seyedsadr, Sepideh Dashti · 2018 · Journal of Human Genetics and Genomics
- Morphological changes of the rats pancreas after the joint influence of the dosed normobaric hypoxia and melatoninRoman V. Yanko · 2018 · Bulletin of Taras Shevchenko National University of Kyiv Series “Psychology”
- The combined effect of intermittent normobaric hypoxia and melatonin on the morphological changes of the spontaneously hypertensive rats pancreasRoman V. Yanko, Mikhail I. Levashov, I. H. Litovka, Sergey Safonov · 2019 · Pathologia
- A melatoninreceptor 1B rs10830963 génvariáns szerepe a terhességi cukorbetegség kialakulásában és kezelésébenGábor Firneisz, Klára Rosta, Zahra Al‐Aissa, Ákos Nádasdi, Orsolya Hadarits, János Jr. Rigó, Anikó Somogyi · 2019 · Diabetologia Hungarica
- Novel Gluconeogenesis Regulators for Anti-diabetic Drug Repurposing using Transgenic Zebrafish pck1 ReportersJi Dong K. Bai · 2015 · TSpace (University of Toronto)
- Melatonin in menopausal metabolic syndrome formation.E. V. Bruhina, A. G. Mamontova, Elena N. Usoltseva · 2018 · Clinical Medicine (Russian Journal)
- Vias aéreas superiores e desordens respiratórias do sono em indivíduos com fissura labiopalatina e discrepância maxilomandibular: análise por polissonografia, tomografia computadorizada de feixe cônico e fluidodinâmica computacionalLetícia Dominguez Campos · 2017
- Cytoprotection by Melatonin: The Metabolic Syndrome as an ExampleDaniel Pedro Cardinali, Daniel Eduardo Vigo · 2021 · Springer eBooks
- Endocrinology of SleepDorit Koren · 2021 · Springer eBooks
- Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatmentJesse Joachim Swen, Judith A.M. Wessels, Willem JJ Assendelft, Henk‐Jan Guchelaar · 2012 · European Journal of Hospital Pharmacy
- Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases: Role of Ion ChannelsAbdülhadi Cihangir Uğuz, Lourdes Franco Hernández, Jaipaul Singh, Ana Beatriz Rodriguez Moratinos, José Antonio Pariente · 2021 · Advances in biochemistry in health and disease
- Targeting Islet GPCRs to Improve Insulin SecretionPatricio Atanes, Inmaculada Ruz‐Maldonado, Shanta Jean Persaud · 2021 · Elsevier eBooks
- Current World Literature2009 · Current Opinion in Lipidology
- Circadian Control of Islet FunctionJeongkyung Lee, Mousumi Moulik, Vijay K. Yechoor · 2013 · Springer eBooks
- Current World Literature2009 · Current Opinion in Endocrinology Diabetes and Obesity
- In Brief2009 · Nature Reviews Endocrinology
- Metabolism: Hereditary ErrorsLeif Groop, Anders H. Rosengren · 2011 · Encyclopedia of Life Sciences
- MelatoninRüdiger Hardeland · 2018 · Elsevier eBooks