Heritability and genomics of gene expression in peripheral blood

Wright, Fred A, Sullivan, Patrick F, Brooks, Andrew I, Zou, Fei, Sun, Wei, Xia, Kai, Madar, Vered, Jansen, Rick +31 more·2014·Nature Genetics

DOI 10.1038/ng.2951

Cited by (364)

Items 201–300 of 364

Genetic analysis of the blood transcriptome of young healthy pigs to improve disease resilience
Kyu‐Sang Lim, Jian Cheng, Christopher Keith Tuggle, Michael K. Dyck, PigGen Canada, Frédéric Fortin, John C. S. Harding, Graham Stuart Plastow, Jack C. M. Dekkers · 2023 · Genetics Selection Evolution
Transcriptomic analyses of humans and mice provide insights into depression
Huijuan Li, 中国科学院昆明动物研究所，中国科学院与云南省动物模型与人类疾病机理重点实验室，云南昆明 650223，中国, Xi Su, Lu-Wen Zhang, Chuyi Zhang, Lu Wang, Wenqiang Li, Yongfeng Yang, Luxian Lv, Ming Li et al. · 2020 · 动物学研究
Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Zhongshang Yuan · 2020 · Frontiers in Genetics
Estimation of cis-eQTL Effect Sizes Using a Log of Linear Model
John Palowitch, A. Shabalin, Yi-Hui Zhou, A. Nobel, F. Wright · 2017 · Biometrics
Allele frequency differences of causal variants have a major impact on low cross-ancestry portability of PRS
Marie Saitou, Andy W. Dahl, Qingbo Wang, Xuanyao Liu · 2022 · medRxiv
Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes
Fangtang Yu, Chuan Qiu, Chao Xu, Qing Tian, Lan‐Juan Zhao, Li Wu, Hong‐Wen Deng, Hui Shen · 2020 · Frontiers in Genetics
Survey of the Heritability and Sparse Architecture of Gene Expression Traits Across Human Tissues
Heather E. Wheeler, Kaanan P. Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, Nancy Jean Cox, Dan L. Nicolae, Hae Kyung Im · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines
Marie Saitou, Andy W. Dahl, Qingbo Wang, Xuanyao Liu · 2024 · The American Journal of Human Genetics
GLP1R Gene Expression and Kidney Disease Progression
Jefferson L. Triozzi, Zhihong Yu, Ayush Giri, Hua‐Chang Chen, Otis D. Wilson, Brian R. Ferolito, Talat Alp Ikizler, Elvis A. Akwo, Cassianne Robinson‐Cohen, J. Michael Gaziano et al. · 2024 · JAMA Network Open
A computational method for cell type-specific expression quantitative trait loci mapping using bulk RNA-seq data
Paul Little, Siming Liu, Vasyl Zhabotynsky, Yun Li, Dan-Yu Lin, Wei Sun · 2023 · bioRxiv
Using Stochastic Approximation Techniques to Efficiently Construct Confidence Intervals for Heritability
Regev Schweiger, Eyal Fisher, Elior Rahmani, Liat Shenhav, Saharon Rosset, Eran Halperin · 2018 · Journal of Computational Biology
Tejaas: reverse regression increases power for detecting trans-eQTLs
Saikat Banerjee, Franco L. Simonetti, Kira E. Detrois, Anubhav Kaphle, Raktim Mitra, Rahul Nagial, Johannes Söding · 2021 · Genome biology
Estimating the proportion of disease heritability mediated by gene expression levels
Luke Jen O’Connor, Alexander Gusev, Xuanyao Liu, Po‐Ru Loh, Hilary K. Finucane, Alkes L. Price · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
Twins and omics: the role of twin studies in multi-omics
Fiona A. Hagenbeek, Jenny van Dongen, René Pool, Dorret Irene Boomsma · 2022 · Elsevier eBooks
Efficient and effective control of confounding in eQTL mapping studies through joint differential expression and Mendelian randomization analyses
Yue Fan, Huanhuan Zhu, Yanyi Song, Qinke Peng, Xiang Zhou · 2020 · Bioinformatics
The genetic architecture of molecular traits
Annique Claringbould, Niek de Klein, Lude Franke · 2017 · Current Opinion in Systems Biology
Early Detection of Neurological Dysfunction Using Blood Cell Transcript Profiles
Mohammad Ali Moni, Humayan Kabir Rana, M. Babul Islam, Md Bashir Ahmed, Pietro Liò, Fazlul Huq, Julian M.W. Quinn · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets
Lara Bossini‐Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms
Xiangning Chen, Yimei Lu, Joan Manuel Cue, Mira Han, Vishwajit Laxmikant Nimgaonkar, Daniel R. Weinberger, Shizhong Han, Zhongming Zhao, Jingchun Chen · 2025 · Schizophrenia
Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens
Fang-Ren Lan, Xi-Qiong Wang, Qianqian Zhou, Xiao-Chang Li, Jiaming Jin, Wenxin Zhang, Chao-Liang Wen, Gui-Qin Wu, Guang-Qi Li, Yi-Yuan Yan et al. · 2025 · Microbiome
Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritis
Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Huimiao Song, Hui-Wu Gao et al. · 2025 · EBioMedicine
The 1000 Chinese Pangenome empowers medical and population genetics
Yifei Wang, Zhongqu Duan, Dan Chen, Dandan Shi, Yi Ding, Zhibin Wang, Baoqing Li, Zhiyi Wang, Minmin Guo, Wen Yang et al. · 2026 · Nature
eQTL Set–Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma
Xiaoyu Wang, Puya Gharahkhani, David Levine, Rebecca Claire Fitzgerald, Ines Gockel, Douglas A. Corley, Harvey A. Risch, Leslie Bernstein, Wong‐Ho Chow, Lynn Onstad et al. · 2022 · Cancer Epidemiology Biomarkers & Prevention
A transcriptome-wide association study of uterine fibroids to identify potential genetic markers and toxic chemicals
Gayeon Kim, Gyuyeon Jang, Jaeseung Song, Daeun Kim, Sora Lee, Jong Wha J. Joo, Wonhee Jang · 2022 · PLoS ONE
A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex
Jinglu Wang, Susu Qu, Weixiao Wang, Liyuan Guo, Kunlin Zhang, Suhua Chang, Jing Wang · 2016 · Journal of Psychiatric Research
Designing penalty functions in high dimensional problems: The role of tuning parameters
Ting-Huei Chen, Wei Sun, Jason P. Fine · 2016 · Electronic Journal of Statistics
Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
Regev Schweiger, Eyal Fisher, Omer Weissbrod, Elior Rahmani, Martina Müller‐Nurasyid, Sonja Kunze, Christian Gieger, Mélanie Waldenberger, Saharon Rosset, Eran Halperin · 2018 · Nature Communications
Gene-based association tests using GWAS summary statistics and incorporating eQTL
Xuewei Cao, Xue-Xia Wang, Shuang-Lin Zhang, Qiu-Ying Sha · 2021 · Scientific Reports
Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data
René Pool, Fiona A. Hagenbeek, Anne M. Hendriks, Jenny van Dongen, Gonneke A. H. M. Willemsen, Eco J. C. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka D. Suchiman, Marian Beekman et al. · 2020 · Twin Research and Human Genetics
Identification of Reproducible BCL11A Alterations in Schizophrenia Through Individual-Level Prediction of Coexpression
Junfang Chen, Han Cao, Tobias Kaufmann, Lars Tjelta Westlye, Heike Tost, Andreas Meyer‐Lindenberg, Emanuel Schwarz · 2020 · Schizophrenia Bulletin
Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genes
Vahid Gazestani, Austin W.T. Chiang, Eric Courchesne, Nathan E. Lewis · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Protein–protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits
J. Li, Yang Li, Xuanyao Liu · 2026 · Nature Genetics
Chromosomal characteristics of salt stress heritable gene expression in the rice genome
Matthew McGowan, Zhiwu Zhang, Stephen Patrick Ficklin · 2021 · BMC Genomic Data
Methylation as an epigenetic source of random genetic effects in the classical twin design
Dorret Irene Boomsma, Conor V. Dolan, Michel Guillaume Nivard, Jenny van Dongen, Sophie van der Sluis · 2015 · Advances in Genomics and Genetics
Another Round of “Clue” to Uncover the Mystery of Complex Traits
Shefali S. Verma, Marylyn DeRiggi Ritchie · 2018 · Genes
Transcriptome-wide association study of HIV-1 acquisition identifies HERC1 as a susceptibility gene
Rodrigo R. R. Duarte, Oliver Pain, Robert L. Furler O’Brien, Douglas F. Nixon, Timothy R. Powell · 2022 · iScience
Peripheral blood multimodal integration via cross-attention for cancer immune profiling
Xiong Li, Yi Hua, Hongwei Liu, Juan Zhou, Yuejin Zhang, Haowen Chen · 2025 · BMC Cancer
Genome-Wide Association Analysis of Neonatal White Matter Microstructure
J Zhang, Kai Xia, Mihye Ahn, Shaili C. Jha, Reid Blanchett, James J. Crowley, Jin Szatkiewicz, Fei Zou, Hongtu Zhu B, Martin Andreas Styner et al. · 2020 · Cerebral Cortex
Trans -acting genetic variation affects the expression of adjacent genes
Krisna Van Dyke, Sheila Lutz, Gemechu Mekonnen, Chad L. Myers, Frank Wolfgang Albert · 2021 · Genetics
Evidence for a maintenance cost for birds maintaining highly flexible basal, but not summit, metabolic rates
David L. Swanson, Maria Stager, François Vézina, Jinsong Liu, Andrew E. McKechnie, Reza Goljani Amirkhiz · 2023 · Scientific Reports
Gene expression shifts in yellow-bellied marmots prior to natal dispersal
Tiffany C. Armenta, Steve W. Cole, Daniel H. Geschwind, Daniel T. Blumstein, Robert K. Wayne · 2018 · Behavioral Ecology
Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels
Amanda J. Lea, Julie Peng, Julien F. Ayroles · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Gene Expression of Inflammation Markers in Depression
Liliana G Ciobanu, Bernhard Theodor Baune · 2018 · Elsevier eBooks
Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis
Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Chul Woo Ahn, Wonhee Jang, Wonhee Jang · 2024 · Arthritis Research & Therapy
Concerted Genetic Function in Blood Traits
Sarah Kim-Hellmuth, Tuuli Lappalainen · 2016 · Cell
Alterations observed in the interferon α and β signaling pathway in MDD patients are marginally influenced by cis-acting alleles
Chiara Magri, Edoardo Giacopuzzi, Chiara Sacco, Luisella Bocchio‐Chiavetto, Alessandra Minelli, Massimo Gennarelli · 2021 · Scientific Reports
Integrative cross-omics and cross-context analysis elucidates molecular links underlying genetic effects on complex traits
Yihao Lu, Meritxell Oliva, Brandon L. Pierce, Jin Liu, Lin S. Chen · 2024 · Nature Communications
Consistency of biological networks inferred from microarray and sequencing data
Veronica Vinciotti, Ernst C. Wit, Rick Jansen, Eco J. C. de Geus, Brenda W.J.H. Penninx, Dorret Irene Boomsma, Peter A.C. ’t Hoen · 2016 · BMC Bioinformatics
A cis -eQTL in AHI1 confers risk to schizophrenia in European populations
Zixiao Ren, A Zhiwei Qiu, Ai-Qi Zhang, Lijun Huang, Shuquan Rao · 2016 · Neuroscience Letters
Using Stochastic Approximation Techniques to Efficiently Construct Confidence Intervals for Heritability
Regev Schweiger, Eyal Fisher, Elior Rahmani, Liat Shenhav, Saharon Rosset, Eran Halperin · 2017 · Lecture notes in computer science
Generalization and fine mapping of red blood cell trait genetic associations to multi‐ethnic populations: The PAGE study
Chani J. Hodonsky, Claudia Schurmann, Ursula M. Schick, Jonathan Kocarnik, Ran Tao, Frank J.A. van Rooij, Christina L. Wassel, Steven G. Buyske, Myriam Fornage, Lucia A. Hindorff et al. · 2018 · American Journal of Hematology
Systems biology and bioinformatics approach to identify gene signatures, pathways and therapeutic targets of Alzheimer's disease
Utpala Nanda Chowdhury, Md. Babul Islam, Shamim Ahmad, Mohammad Ali Moni · 2020 · Informatics in Medicine Unlocked
Familial resemblances in human whole blood transcriptome
Bénédicte L. Tremblay, Frédéric Guénard, Benoı̂t Lamarche, Louis Përusse, Marie‐Claude Vohl · 2018 · BMC Genomics
A novel cis-regulatory variant modulating TIE1 expression associated with attention deficit hyperactivity disorder in Han Chinese children
Xinzhen Chen, Ting Yao, Jinliang Cai, Qi Zhang, Shanyawen Li, Huiru Li, Xihang Fu, Jing Wu · 2021 · Journal of Affective Disorders
A resource for integrated genomic analysis of the human liver
Yi‐Hui Zhou, Paul J. Gallins, Amy S. Etheridge, Dereje D. Jima, Elizabeth H. Scholl, Fred A. Wright, Federico Innocenti · 2022 · Scientific Reports
Adaptive gene regulation in wild mammals exposed to high predator abundance
Tiffany C. Armenta, Steve W. Cole, Robert K. Wayne, Daniel T. Blumstein · 2019 · Animal Behaviour
Effective SNP ranking improves the performance of eQTL mapping
X. Jessie Jeng, Jacob Rhyne, Teng Zhang, Jung‐Ying Tzeng · 2020 · Genetic Epidemiology
Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder
Christine B. Peterson, Susan K. Service, Anna J. Jasinska, Fuying Gao, Ivette Zelaya, Terri M. Teshiba, Carrie E. Bearden, Rita M. Cantor, Victor I. Reus, Gabriel Macaya et al. · 2016 · PLoS Genetics
Genome-wide studies define new genetic mechanisms of IgA vasculitis
Lili Liu, Li Zhu, Sara Monteiro-Martins, Aaron Timothy Griffin, Lukas J. Vlahos, Masashi Fujita, Cecilia C. Berrouet, Francesca Zanoni, Maddalena Marasà, Jun Y. Zhang et al. · 2024 · medRxiv
Fast eQTL Analysis for Twin Studies
Zhaoyu Yin, Kai Xia, Wonil Chung, Patrick F. Sullivan, Fei Zou · 2015 · Genetic Epidemiology
Trans-eQTLs identified in whole blood have limited influence on complex disease biology
Chloe X. Yap, Luke R. Lloyd‐Jones, Alexander Holloway, Peter Smartt, Naomi R. Wray, Jacob Gratten, Joseph E. Powell · 2018 · European Journal of Human Genetics
Person-Specific Non-shared Environmental Influences in Intra-individual Variability: A Preliminary Case of Daily School Feelings in Monozygotic Twins
Yao Zheng, Peter C. M. Molenaar, Rosalind Arden, Kathryn Asbury, David M. Almeida · 2016 · Behavior Genetics
Gene expression in peripheral blood in treatment-free major depression
Alfredo B. Cuellar Barboza, Jorge A. Sánchez-Ruiz, Iram Pablo Rodriguez-Sanchez, Sarai González, Geovana Calvo‐Anguiano, José de Jesús Lugo-Trampe, Antonio Costilla-Esquivel, Laura E. Martínez, Marisol Ibarra‐Ramírez · 2020 · Acta Neuropsychiatrica
DataRemix: a universal data transformation for optimal inference from gene expression datasets
Weiguang Mao, Javad Rahimikollu, Ryan M. Hausler, Maria D. Chikina · 2020 · Bioinformatics
Improved estimation of SNP heritability using Bayesian multiple-phenotype models
Najla Saad Elhezzani · 2018 · European Journal of Human Genetics
RL-SKAT: An exact and efficient score test for heritability and set tests
Regev Schweiger, Omer Weissbrod, Elior Rahmani, Martina Müller‐Nurasyid, Sonja Kunze, Christian Gieger, Mélanie Waldenberger, Saharon Rosset, Eran Halperin · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
Causal network inference of cis- and trans-gene regulation of expression quantitative trait loci across human tissues
Jarred Kvamme, Md. Bahadur Badsha, Evan A. Martin, Jiayu Wu, Xiaoyue Wang, Audrey Qiuyan Fu · 2025 · Genetics
Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks
Jessica Strosahl, Kaixiong Ye, Robert Pazdro · 2024 · BMC Genomics
Genetics: From Molecule to Society
Michel Guillaume Nivard, Dorret Irene Boomsma · 2016 · Current Biology
Multilevel Dynamic Twin Modeling
Noémi Katalin Schuurman, Yao Zheng, Conor V. Dolan · 2021 · Structural Equation Modeling A Multidisciplinary Journal
Influence of gonadal steroids on cortical surface area in infancy
Ann Mary Alex, Tom Ruvio, Kai Xia, Shaili C. Jha, Jessica B. Girault, Li Wang, Gang Li, Dinggang G. Shen, Emil A. Cornea, Martin Andreas Styner et al. · 2021 · Cerebral Cortex
Accounting for isoform expression increases power to identify genetic regulation of gene expression
Nathan LaPierre, Harold Pimentel · 2024 · PLoS Computational Biology
Quantifying the impact of genetically regulated expression on complex traits and diseases
Mingxuan Cai, Lin Chen, Jin Liu, Can Yang · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
The Creative Mind: Blending Oxytocinergic, Dopaminergic and Personality
Anne Chong, Benjamin Becker, Dario C. Angeles, Maria Gutierrez Matos, Xiong Yue, Poh San Lai, Mike W.‐L. Cheung, Zhen Lei, Fabio Malavasi, Soo Hong Chew et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Electronic Health Record-Based Genome-Wide Meta-Analysis Provides New Insights on the Genetic Architecture of Non-Alcoholic Fatty Liver Disease
Nooshin Ghodsian, Erik Abner, Connor A. Emdin, Émilie Gobeil, Nele Taba, Mary E. Haas, Nicolas Perrot, Hasanga D. Manikpurage, Éloi Gagnon, Jérôme Bourgault et al. · 2021 · SSRN Electronic Journal
Genetic landscape of an in vivo protein interactome
Savandara Besse, Tatsuya Sakaguchi, Louis Gauthier, Zahra Sahaf, Olivier Péloquin, Lidice González, Xavier Castellanos-Girouard, Nazlı Kocatuğ, Chloé Matta, Julie Hussin et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Assisted clustering of gene expression data using regulatory data from partially overlapping sets of individuals
Wenqing Jiang, Roby Joehanes, Daniel A Levy, George T. O’Connor, Josée Dupuis · 2022 · BMC Genomics
Genetic correlations among diaphragmatic, femoral, inguinal, ventral, and umbilical hernias and identification of their candidate genes
Hekai Shi, Hui Ma, Qijun Li, Junliang Ma, Xiaoyu Peng, Dongchao Yang, Zhicheng Song, Yan Gu · 2026 · International Journal of Surgery
Proteins in Scalp Hair of Preschool Children
Cynthia R. Rovnaghi, Kratika Singhal, Ryan D. Leib, Maria Xenochristou, Nima Aghaeepour, Allis Chien, Deendayal Dinakarpandian, Kanwaljeet J. S. Anand · 2024 · Psych
Mapping of Expression Quantitative Trait Loci Using RNA-seq Data
Wei Sun, Yi‐Juan Hu · 2014 · Springer eBooks
Phenotypic variance partitioning by transcriptomic gene expression levels and environmental variables for anthropometric traits using GTEx data
Pastor Jullian, Sang Lee · 2023 · Genetic Epidemiology
Functional partitioning of local and distal gene expression regulation in multiple human tissues
Xuanyao Liu, Hilary K. Finucane, Alexander Gusev, Gaurav Bhatia, Steven Gazal, Luke Jen O’Connor, Brendan K Bulik-Sullivan, Fred A. Wright, Patrick F. Sullivan, Benjamin M. Neale et al. · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Estimation of Interpretable eQTL Effect Sizes Using a Log of Linear Model
John Palowitch, A. Shabalin, Yi-Hui Zhou, A. Nobel, F. Wright · 2016 · arXiv (Cornell University)
Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits
Nicholas Mancuso, Huwenbo Shi, Pagé C. Goddard, Gleb Kichaev, Alexander Gusev, Bogdan Paşaniuc · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Identification of Brain Expression Quantitative Trait Loci Associated with Schizophrenia and Affective Disorders in Normal Brain Tissue
Oneil G. Bhalala, Artika P. Nath, Michael Inouye, Christopher R. Sibley · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Identification of expression quantitative trait loci in the skeletal muscle of Thoroughbreds reveals heritable variation in expression of genes relevant to cofactor metabolism
Gabriella Farries, Kenneth R. Bryan, Charlotte L. McGivney, Paul McGettigan, Katie F. Gough, John Arthur Browne, David Evan MacHugh, Lisa Michelle Katz, Emmeline Wynne Hill · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Gene expression imputation provides insight into the genetic architecture of frontotemporal dementia
Lianne Maria Reus, Bogdan Paşaniuc, Daniëlle Posthuma, Toni A. Boltz, Yolande A.L. Pijnenburg, Roel A. Ophoff · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
Gabin Drouard, Fiona A. Hagenbeek, Alyce M. Whipp, René Pool, Jouke‐Jan Hottenga, Rick Jansen, Nikki Hubers, Aleksei Afonin, Gonneke A. H. M. Willemsen, Eco J. C. de Geus et al. · 2023 · medRxiv
Heritability of Gene Expression Measured from Peripheral Blood in Older Adults
Sri C. Kanchibhotla, Karen A. Mather, Nicola J. Armstrong, Liliana G Ciobanu, Bernhard Theodor Baune, Vibeke Sorensen Catts, Peter R. Schofield, Julian Norman Trollor, David J. Ames, Perminder Singh Sachdev et al. · 2024 · Genes
Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals
Jennifer Zou, Emily Maciejewski, Jason Ernst · 2025 · Communications Biology
Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy
Zijian Ma, Qing Hou, Ruixiang Yang, Jingsong Shi, Shuyan Kan, Chun-Xia Zheng, Xiaodong Zhu, Zhi-hong Liu, Song Jiang · 2025 · Genome Medicine
Heritability Patterns of Protein‐Coding Genes Expression: Insights From the Pig Genotype‐Tissue Expression Project
Chao Su, Wei Zhang, Wenzhe Ning, Jinyan Teng, Yahui Gao, Zhe Zhang · 2026 · Animal Genetics
The Family System as a Unit of Clinical Care: The Role of Genetic Systems
David Reiss · 2015 · Springer eBooks
Cap Analysis of Gene Expression Clarifies Transcriptomic Divergence Within Monozygotic Twin Pairs
Hirokazu Katoh, Hiroaki Asai, Keiko Takemoto, Rie Tomizawa, Chika Honda, Mikio Watanabe, Tomoyuki Honda · 2023 · Twin Research and Human Genetics
Molecular phenotypes that are causal to complex traits can have low heritability and are expected to have small influence
Leopold Parts · 2014 · bioRxiv (Cold Spring Harbor Laboratory)
Haplotype-based eQTL mapping finds evidence for complex gene regulatory regions poorly tagged by marginal SNPs
Robert Brown, Sriram Sankararaman, Bogdan Paşaniuc · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
An integrative analysis of GWAS and intermediate molecular trait data reveals common molecular mechanisms supporting genetic similarity between seemingly unrelated complex traits
Jialiang Gu, Chris Fuller, Jiashun Zheng, Hao Li · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
GWAS of epigenetic ageing rates in blood reveals a critical role for TERT
Ake Tzu-Hui Lu, Luting Xue, Elias Salfati, Brian H. Chen, Luigi Ferrucci, Daniel A Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
Untargeted metabolome- and transcriptome-wide association study identifies causal genes modulating metabolite concentrations in urine
Reyhan Sönmez Flitman, Bita Khalili, Zoltán Kutalik, Rico Rueedi, Sven Bergmann · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease
Nooshin Ghodsian, Erik Abner, Connor A. Emdin, Émilie Gobeil, Nele Taba, Mary J. Haas, Nicolas Perrot, Hasanga D. Manikpurage, Éloi Gagnon, Jérôme Bourgault et al. · 2020