The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Genetic architecture of artemisinin-resistant Plasmodium falciparum
Open accessAbstract
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, which were associated with a slow parasite clearance rate after treatment with artemisinin derivatives. Nonsynonymous polymorphisms in fd (ferredoxin), arps10 (apicoplast ribosomal protein S10), mdr2 (multidrug resistance protein 2) and crt (chloroquine resistance transporter) also showed strong associations with artemisinin resistance. Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance. These findings indicate that the risk of new resistance-causing mutations emerging is determined by specific predisposing genetic factors in the underlying parasite population.
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Accurate whole human genome sequencing using reversible terminator chemistry
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Artemisinin Resistance in Plasmodium falciparum Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424
Self-citationSpread of Artemisinin Resistance in Plasmodium falciparum Malaria
Ashley, E. A., Dhorda, M., Fairhurst, R. M., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Mao, S., Sam, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314981 · Cited by 2,205
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Self-citationAntimalarial Drug Resistance: A Threat to Malaria Elimination
Menard, D., & Dondorp, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025619 · Cited by 499
Self-citationTun, K. M., Imwong, M., Lwin, K. M., Win, A. A., Hlaing, T. M., Hlaing, T., Lin, K., Kyaw, M. P., Plewes, K., Faiz, M. A., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70032-0 · Cited by 414
Self-citationAmato, R., Lim, P., Miotto, O., Amaratunga, C., Dek, D., Pearson, R. D., Almagro-Garcia, J., Neal, A. T., Sreng, S., Suon, S., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30409-1 · Cited by 401
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Metadata
- Authors
- Miotto, O., Amato, R., Ashley, E. A., MacInnis, B., Almagro-Garcia, J., Amaratunga, C., Lim, P., Mead, D., Oyola, S. O., Dhorda, M., Imwong, M., Woodrow, C., Manske, M., Stalker, J., Drury, E., Campino, S., Amenga-Etego, L., Thanh, T.-N. N., Tran, H. T., Ringwald, P., Bethell, D., Nosten, F., Phyo, A. P., Pukrittayakamee, S., Chotivanich, K., Chuor, C. M., Nguon, C., Suon, S., Sreng, S., Newton, P. N., Mayxay, M., Khanthavong, M., Hongvanthong, B., Htut, Y., Han, K. T., Kyaw, M. P., Faiz, M. A., Fanello, C. I., Onyamboko, M., Mokuolu, O. A., Jacob, C. G., Takala-Harrison, S., Plowe, C. V., Day, N. P., Dondorp, A. M., Spencer, C. C. A., McVean, G., Fairhurst, R. M., White, N. J., & Kwiatkowski, D. P.
- Venue
- Nature Genetics
- Published
- 2015-01-19
- Volume
- 47
- Issue
- 3
- Pages
- 226-234
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1969571661
- Cited by
- 609
- References
- 5
- FWCI
- 73.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Miotto, O., Amato, R., Ashley, E. A., MacInnis, B., Almagro-Garcia, J., Amaratunga, C., Lim, P., Mead, D., Oyola, S. O., Dhorda, M., Imwong, M., Woodrow, C., Manske, M., Stalker, J., Drury, E., Campino, S., Amenga-Etego, L., Thanh, T.-N. N., Tran, H. T., . . . Kwiatkowski, D. P. (2015). Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nature Genetics. https://doi.org/10.1038/ng.3189
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