The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
Open accessAbstract
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa 1–4. Here we genotyped the P. falciparum K13 (Pfkelch13) propeller domain, mutations in which can mediate artemisinin resistance 5,6, in pretreatment samples collected from recent dihydroarteminisin-piperaquine and artemether-lumefantrine efficacy trials in Rwanda 7. While cure rates were >95% in both treatment arms, the Pfkelch13 R561H mutation was identified in 19 of 257 (7.4%) patients at Masaka. Phylogenetic analysis revealed the expansion of an indigenous R561H lineage. Gene editing confirmed that this mutation can drive artemisinin resistance in vitro. This study provides evidence for the de novo emergence of Pfkelch13-mediated artemisinin resistance in Rwanda, potentially compromising the continued success of antimalarial chemotherapy in Africa.
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Artemisinin Resistance in Plasmodium falciparum Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424
Self-citationSpread of Artemisinin Resistance in Plasmodium falciparum Malaria
Ashley, E. A., Dhorda, M., Fairhurst, R. M., Amaratunga, C., Lim, P., Suon, S., Sreng, S., Anderson, J. M., Mao, S., Sam, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314981 · Cited by 2,205
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., et al. (2014) · Nature · doi:10.1038/nature12876 · Cited by 2,090
Self-citationGlobal malaria mortality between 1980 and 2010: a systematic analysis
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White, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Straimer, J., Gnädig, N. F., Witkowski, B., Amaratunga, C., Duru, V., Ramadani, A. P., Dacheux, M., Khim, N., Zhang, L., Lam, S., et al. (2015) · Science · doi:10.1126/science.1260867 · Cited by 728
Self-citationWitkowski, B., Amaratunga, C., Khim, N., Sreng, S., Chim, P., Kim, S., Lim, P., Mao, S., Sopha, C., Sam, B., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70252-4 · Cited by 629
Self-citationGenetic architecture of artemisinin-resistant Plasmodium falciparum
Miotto, O., Amato, R., Ashley, E. A., MacInnis, B., Almagro-Garcia, J., Amaratunga, C., Lim, P., Mead, D., Oyola, S. O., Dhorda, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3189 · Cited by 609
Self-citationAntimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
Blasco, B., Leroy, D., & Fidock, D. A. (2017) · Nature Medicine · doi:10.1038/nm.4381 · Cited by 576
Self-citationA Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
Ménard, D., Khim, N., Beghain, J., Adegnika, A. A., Shafiul-Alam, M., Amodu, O., Rahim-Awab, G., Barnadas, C., Berry, A., Boum, Y., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513137 · Cited by 551
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Cited by
Uwimana, A., Umulisa, N., Venkatesan, M., Svigel, S. S., Zhou, Z., Munyaneza, T., Habimana, R. M., Rucogoza, A., Moriarty, L. F., Sandford, R., et al. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00142-0 · Cited by 435
Self-citationMolecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Wicht, K. J., Mok, S., & Fidock, D. A. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115546 · Cited by 322
Self-citationEmiru, T., Getachew, D., Murphy, M., Sedda, L., Ejigu, L. A., Bulto, M. G., Byrne, I., Demisse, M., Abdo, M., Chali, W., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02641-9 · Cited by 162
Anopheles stephensi in Africa requires a more integrated response
Mnzava, A., Monroe, A. C., & Okumu, F. (2022) · Malaria Journal · doi:10.1186/s12936-022-04197-4 · Cited by 95
Nayak, S., Peto, T. J., Kucharski, M., Tripura, R., Callery, J. J., Quang Huy, D. T., Gendrot, M., Lek, D., Nghia, H. D. T., van der Pluijm, R. W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54915-6 · Cited by 15
Metadata
- Authors
- Uwimana, A., Legrand, E., Stokes, B. H., Ndikumana, J.-L. M., Warsame, M., Umulisa, N., Ngamije, D., Munyaneza, T., Mazarati, J.-B., Munguti, K., Campagne, P., Criscuolo, A., Ariey, F., Murindahabi, M., Ringwald, P., Fidock, D. A., Mbituyumuremyi, A., & Menard, D.
- Venue
- Nature Medicine
- Published
- 2020-08-03
- Volume
- 26
- Issue
- 10
- Pages
- 1602-1608
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3046809066
- Cited by
- 831
- References
- 36
- FWCI
- 85.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Uwimana, A., Legrand, E., Stokes, B. H., Ndikumana, J.-L. M., Warsame, M., Umulisa, N., Ngamije, D., Munyaneza, T., Mazarati, J.-B., Munguti, K., Campagne, P., Criscuolo, A., Ariey, F., Murindahabi, M., Ringwald, P., Fidock, D. A., Mbituyumuremyi, A., & Menard, D. (2020). Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nature Medicine. https://doi.org/10.1038/s41591-020-1005-2
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