The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Genomic landscape of cutaneous T cell lymphoma
Open accessAbstract
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs versus 1.0 somatic single-nucleotide variant per CTCL). These findings have implications for new therapeutics.
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Metadata
- Authors
- Choi, J., Goh, G., Walradt, T., Hong, B. S., Bunick, C. G., Chen, K., Bjornson, R. D., Maman, Y., Wang, T., Tordoff, J., Carlson, K., Overton, J. D., Liu, K. J., Lewis, J. M., Devine, L., Barbarotta, L., Foss, F. M., Subtil, A., Vonderheid, E. C., Edelson, R. L., Schatz, D. G., Boggon, T. J., Girardi, M., & Lifton, R. P.
- Venue
- Nature Genetics
- Published
- 2015-07-20
- Volume
- 47
- Issue
- 9
- Pages
- 1011-1019
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W980720098
- Cited by
- 428
- References
- 73
- FWCI
- 41.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Choi, J., Goh, G., Walradt, T., Hong, B. S., Bunick, C. G., Chen, K., Bjornson, R. D., Maman, Y., Wang, T., Tordoff, J., Carlson, K., Overton, J. D., Liu, K. J., Lewis, J. M., Devine, L., Barbarotta, L., Foss, F. M., Subtil, A., Vonderheid, E. C., . . . Lifton, R. P. (2015). Genomic landscape of cutaneous T cell lymphoma. Nature Genetics. https://doi.org/10.1038/ng.3356
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