Cited by 326Lymphoma Diagnosis and TreatmentCancer Immunotherapy and BiomarkersCytokine Signaling Pathways and Interactions

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

Open access
Song, Tammy Linlin, Nairismägi, Maarja-Liisa, Laurensia, Yurike, Lim, Jing-Quan, Tan, Jing, Li, Zhi-Mei, Pang, Wan-Lu, Kizhakeyil, Atish +21 more·2018·Blood

Abstract

Key Points: Alterations in JAK/STAT signaling pathway are highly prevalent in PTCL and NKTL, where STAT3 and TP53 are the most frequently mutated genes. STAT3 activation drives PD-L1 expression in NKTL, providing a rationale to combine STAT3 inhibitors with immune checkpoint inhibitors.

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Crossref · 10.1182/blood-2018-01-829424

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Authors
Song, T. L., Nairismägi, M.-L., Laurensia, Y., Lim, J.-Q., Tan, J., Li, Z.-M., Pang, W.-L., Kizhakeyil, A., Wijaya, G.-C., Huang, D.-C., Nagarajan, S., Chia, B. K.-H., Cheah, D., Liu, Y.-H., Zhang, F., Rao, H.-L., Tang, T., Wong, E. K.-Y., Bei, J.-X., Iqbal, J., Grigoropoulos, N.-F., Ng, S.-B., Chng, W.-J., Teh, B.-T., Tan, S.-Y., Verma, N. K., Fan, H., Lim, S.-T., & Ong, C.-K.
Affiliations
  • Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, and
  • Sun Yat-sen University (CN)
  • National Cancer Centre Singapore (SG)
  • Nanyang Technological University (SG)
  • Guangdong General Hospital (CN)
  • National University of Singapore (SG)
  • Singapore General Hospital (SG)
  • National University Hospital (SG)
  • Agency for Science, Technology and Research (SG)
Corresponding author
  • Song, Tammy Linlin
  • Nairismägi, Maarja-Liisa
Venue
Blood
Published
2018-09-13
Volume
132
Issue
11
Pages
1146-1158
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2622400061
Cited by
326
References
84
Citations by year
2026: 21 · 2025: 43 · 2024: 36 · 2023: 45 · 2022: 46 · 2021: 59 · 2020: 48 · 2019: 23 · 2018: 5
FWCI
26.43
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
  • DR-NTU (Nanyang Technological University) (submittedVersion)
Funders
  • National Cancer Centre of Singapore
  • Duke-NUS Medical School
  • Tanoto Foundation
  • Singapore General Hospital
  • Nanyang Technological University
  • Sun Yat-sen University
  • Medical Research Council
  • National Medical Research Council
  • Lee Kong Chian School of Medicine, Nanyang Technological University
  • Biomedical Research Council
  • Sun Yat-sen University Cancer Center
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
STAT3 activation, PD-L1 expression, natural killer/T-cell lymphoma, tumor immune evasion, PD-1/PD-L1 blockade, STAT3 inhibitor, primary T-cell lymphoma, oncogenic signaling
MeSH terms
Humans, Neoplasm Proteins, Signal Transduction, Gene Expression Regulation, Neoplastic, Amino Acid Substitution, Mutation, Missense, Cell Line, Tumor, STAT3 Transcription Factor, Lymphoma, Extranodal NK-T-Cell, B7-H1 Antigen

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