Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
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Key Points: Alterations in JAK/STAT signaling pathway are highly prevalent in PTCL and NKTL, where STAT3 and TP53 are the most frequently mutated genes. STAT3 activation drives PD-L1 expression in NKTL, providing a rationale to combine STAT3 inhibitors with immune checkpoint inhibitors.
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Various critical transcription factors, including HIF-1α, c-MYC, NF-kB, STAT3, c-JUN, and miR-138-5p, have been shown to transcriptionally regulate PD-L1 expression.
“Various critical transcription factors, including HIF-1α, c-MYC, NF-kB, STAT3, c-JUN, and miR-138-5p have been shown to transcriptionally regulate PD-L1 expression25–30.”
From PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells (2022) · cites this paper as [28]
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Comparative Protein Modelling by Satisfaction of Spatial Restraints
Šali, A., & Blundell, T. L. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1626 · Cited by 12,977 · see citing works
UniProt: the Universal Protein knowledgebase
Apweiler, R. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh131 · Cited by 7,535 · see citing works
Nivolumab in Previously Untreated Melanoma without <i>BRAF</i> Mutation
Robert, C., Long, G. V., Brady, B., Dutriaux, C., Maio, M., Mortier, L., Hassel, J. C., Rutkowski, P., McNeil, C., Kalinka-Warzocha, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412082 · Cited by 5,519 · see citing works
UniProt: the universal protein knowledgebase
The UniProt Consortium (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1099 · Cited by 4,436 · see citing works
Rosenberg, J. E., Hoffman-Censits, J., Powles, T., van der Heijden, M. S., Balar, A. V., Necchi, A., Dawson, N., O'Donnell, P. H., Balmanoukian, A., Loriot, Y., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00561-4 · Cited by 3,669 · see citing works
PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
Ansell, S. M., Lesokhin, A. M., Borrello, I., Halwani, A. S., Scott, E. C., Gutierrez, M. E., Schuster, S. J., Millenson, M. M., Cattry, D., Freeman, G. J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1411087 · Cited by 3,564 · see citing works
TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199 · see citing works
International T-Cell Lymphoma Project (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.4558 · Cited by 2,124 · see citing works
Primary Resistance to PD-1 Blockade Mediated by <i>JAK1/2</i> Mutations
Shin, D. S., Zaretsky, J. M., Escuin-Ordinas, H., Garcia-Diaz, A., Hu-Lieskovan, S., Kalbasi, A., Grasso, C. S., Hugo, W., Sandoval, S., Torrejon, D. Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1223 · Cited by 1,337 · see citing works
Lesina, M., Kurkowski, M. U., Ludes, K., Rose-John, S., Treiber, M., Klöppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.009 · Cited by 862 · see citing works
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Puente, X. S., Beà, S., Valdés‐Mas, R., Villamor, N., Gutiérrez‐Abril, J., Martín-Subero, J. I., Munar, M., Rubio-Pérez, C., Jares, P., Aymerich, M., et al. (2015) · Nature · doi:10.1038/nature14666 · Cited by 813 · see citing works
PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome
Roemer, M. G. M., Advani, R. H., Ligon, A. H., Natkunam, Y., Redd, R. A., Homer, H., Connelly, C. F., Sun, H. H., Daadi, S. E., Freeman, G. J., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.4482 · Cited by 796 · see citing works
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Rajala, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H. A., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T. L., Jalkanen, S. E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114885 · Cited by 775 · see citing works
Marzec, M., Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M. E., Wang, H. Y., Wysocka, M., Cheng, M. M., Ruggeri, B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810958105 · Cited by 731 · see citing works
Anderson, J. R., Armitage, J. O., & Weisenburger, D. D. (1998) · Annals of Oncology · doi:10.1023/a:1008265532487 · Cited by 686 · see citing works
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
Sakata‐Yanagimoto, M., Enami, T., Yoshida, K., Shiraishi, Y., Ishii, R., Miyake, Y., Muto, H., Tsuyama, N., Sato‐Otsubo, A., Okuno, Y., et al. (2014) · Nature Genetics · doi:10.1038/ng.2872 · Cited by 649 · see citing works
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Kataoka, K., Shiraishi, Y., Takeda, Y., Sakata, S., Matsumoto, M., Nagano, S., Maeda, T., Nagata, Y., Kitanaka, A., Mizuno, S., et al. (2016) · Nature · doi:10.1038/nature18294 · Cited by 647 · see citing works
Gritsko, T., Williams, A., Turkson, J., Kaneko, S., Bowman, T., Huang, M., Nam, S., Eweis, I., Diaz, N., Sullivan, D., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1752 · Cited by 563 · see citing works
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Milner, J. D., Vogel, T. P., Forbes, L. R., Ma, C. A., Stray‐Pedersen, A., Niemela, J. E., Lyons, J. J., Engelhardt, K. R., Zhang, Y., Topcagic, N., et al. (2014) · Blood · doi:10.1182/blood-2014-09-602763 · Cited by 560 · see citing works
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Puente, X. S., Beà, S., Valdés‐Mas, R., Villamor, N., Gutiérrez‐Abril, J., Martín-Subero, J. I., Munar, M., Rubio-Pérez, C., Jares, P., Aymerich, M., et al. (2016) · Nature · doi:10.1038/nature18910 · Cited by 546 · see citing works
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
Fukuda, A., Wang, S. C., Morris, J. P., Folias, A. E., Liou, A., Kim, G. E., Akira, S., Boucher, K., Firpo, M., Mulvihill, S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.002 · Cited by 531 · see citing works
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinomaPreprint
Kan, Z., Zheng, H., Liu, X., Li, S., Barber, T. D., Gong, Z., Gao, H., Hao, K., Willard, M. D., Xu, J., et al. (2013) · Genome Research · doi:10.1101/gr.154492.113 · Cited by 524 · see citing works
Kwong, Y., Chan, T. S. Y., Tan, D. C. L., Kim, S. J., Poon, L. M., Mow, B. M. F., Khong, P., Loong, F., Au-Yeung, R. K. H., Iqbal, J., et al. (2017) · Blood · doi:10.1182/blood-2016-12-756841 · Cited by 497 · see citing works
Self-citationCrescenzo, R., Abate, F., Lasorsa, E., Tabbò, F., Gaudiano, M., Chiesa, N., Giacomo, F. D., Spaccarotella, E., Barbarossa, L., Ercole, E., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.006 · Cited by 445 · see citing works
Self-citationGenomic landscape of cutaneous T cell lymphoma
Choi, J., Goh, G., Walradt, T. J., Hong, B. S., Bunick, C. G., Chen, K., Bjornson, R. D., Maman, Y., Wang, T. L., Tordoff, J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3356 · Cited by 429 · see citing works
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 396 · see citing works
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Küçük, C., Jiang, B., Hu, X., Zhang, W., Chan, J. K. C., Xiao, W., Lack, N. A., Alkan, C., Williams, J. C., Avery, K. N., et al. (2015) · Nature Communications · doi:10.1038/ncomms7025 · Cited by 394 · see citing works
Self-citationXu-Monette, Z. Y., Wu, L., Visco, C., Tai, Y. C., Tzankov, A., Liu, W., Montes‐Moreno, S., Dybkær, K., Chiu, A., Orazi, A., et al. (2012) · Blood · doi:10.1182/blood-2012-05-433334 · Cited by 390 · see citing works
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Jiang, L., Gu, Z., Yan, Z., Zhao, X., Xie, Y., Zhang, Z., Pan, C., Hu, Y., Cai, C., Dong, Y., et al. (2015) · Nature Genetics · doi:10.1038/ng.3358 · Cited by 368 · see citing works
Self-citationActivating alleles of JAK3 in acute megakaryoblastic leukemia.
Walters, D. K., Mercher, T., Gu, T., O'Hare, T., Tyner, J., Loriaux, M., Goss, V., Lee, K. A., Eide, C., Wong, M., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.002 · Cited by 347 · see citing works
Systematic Functional Annotation of Somatic Mutations in Cancer
Ng, P. K., Li, J., Jeong, K. J., Shao, S. H., Chen, H., Tsang, Y. H., Sengupta, S., Wang, Z., Bhavana, V. H., Tran, R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.021 · Cited by 328 · see citing works
Weniger, M. A., Melzner, I., Menz, C. K., Wegener, S., Bucur, A. J., Dorsch, K., Mattfeldt, T., Barth, T. F. E., & Mӧller, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209151 · Cited by 324 · see citing works
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
Rampal, R., Ahn, J., Abdel-Wahab, O., Nahas, M., Wang, K., Lipson, D., Otto, G. A., Yelensky, R., Hricik, T., McKenney, A. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407792111 · Cited by 301 · see citing works
Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Koo, G. C., Tan, S., Tang, T. P. L., Poon, S. L., Allen, G. E., Tan, L. H. C., Chong, S. C., Ong, W. S., Tay, K. K. W., Tao, M., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0028 · Cited by 275 · see citing works
Self-citationFujita, Y., Yagishita, S., Hagiwara, K., Yoshioka, Y., Kosaka, N., Takeshita, F., Fujiwara, T., Tsuta, K., Nokihara, H., Tamura, T., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.10 · Cited by 262 · see citing works
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
Pilati, C., Amessou, M., Bihl, M., Balabaud, C. P., Nhieu, J. T. V., Paradis, V., Nault, J., Izard, T., Bioulac‐Sage, P., Couchy, G., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110283 · Cited by 242 · see citing works
Vasmatzis, G., Johnson, S. H., Knudson, R. A., Ketterling, R. P., Braggio, E., Fonseca, R., Viswanatha, D. S., Law, M. E., Kip, N. S., Özsan, N., et al. (2012) · Blood · doi:10.1182/blood-2012-03-419937 · Cited by 234 · see citing works
Melzner, I., Bucur, A. J., Brüderlein, S., Dorsch, K., Hasel, C., Barth, T. F. E., Leithäuser, F., & Möller, P. (2004) · Blood · doi:10.1182/blood-2004-09-3701 · Cited by 215 · see citing works
Kiel, M. J., Sahasrabuddhe, A. A., Rolland, D. C. M., Velusamy, T., Chung, F., Schaller, M. A., Bailey, N. G., Betz, B. L., Miranda, R. N., Porcu, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms9470 · Cited by 209 · see citing works
STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC
Bu, L., Yu, G., Wu, L., Mao, L., Deng, W., Liu, J., Kulkarni, A. B., Zhang, W. F., Zhang, L., & Sun, Z. (2017) · Journal of Dental Research · doi:10.1177/0022034517712435 · Cited by 200 · see citing works
Atsaves, V., Tsesmetzis, N., Chioureas, D., Kis, L. L., Leventaki, V., Drakos, E., Panaretakis, T., Grandér, D., Medeiros, L. J., Young, K. H., et al. (2017) · Leukemia · doi:10.1038/leu.2017.103 · Cited by 184 · see citing works
Niu, G., Briggs, J., Deng, J., Ma, Y., Lee, H., Kortylewski, M., Kujawski, M., Kay, H. D., Cress, W. D., Jove, R., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2177 · Cited by 177 · see citing works
Lee, S., Park, H. Y., Kang, S. Y., Kim, S. J., Hwang, J., Lee, S., Kwak, S. H., Park, K. S., Yoo, H. Y., Kim, W. S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3776 · Cited by 174 · see citing works
On Human Disease-Causing Amino Acid Variants: Statistical Study of Sequence and Structural Patterns
Petukh, M. G., Kucukkal, T. G., & Alexov, E. G. (2015) · Human Mutation · doi:10.1002/humu.22770 · Cited by 166 · see citing works
Bouchekioua, A., Scourzic, L., Wever, O. D., Zhang, Y., Cervera, P., Aline-Fardin, A., Mercher, T., Gaulard, P., Nyga, R., Jeziorowska, D., et al. (2013) · Leukemia · doi:10.1038/leu.2013.157 · Cited by 161 · see citing works
Yin–Yang of costimulation: crucial controls of immune tolerance and function
Nurieva, R. I., Liu, X., & Dong, C. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00769.x · Cited by 157 · see citing works
Nairismägi, M., Tan, J. Y., Lim, J. Q., Nagarajan, S., Ng, C. C. Y., Rajasegaran, V., Huang, D., Lim, W. K., Laurensia, Y., Wijaya, G.-C., et al. (2016) · Leukemia · doi:10.1038/leu.2016.13 · Cited by 151 · see citing works
Self-citationEpigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
Ooi, W. F., Xing, M., Xu, C., Yao, X., Ramlee, M. K., Lim, M. C., Cao, F., Lim, K. J., Babu, D., Poon, L.-F., et al. (2016) · Nature Communications · doi:10.1038/ncomms12983 · Cited by 146 · see citing works
Self-citationPaul, J., Soujon, M., Wengner, A. M., Zitzmann-Kolbe, S., Sturz, A., Haike, K., Keng Magdalene, K. H., Tan, S. H., Lange, M., Tan, S. Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.003 · Cited by 146 · see citing works
Self-citationActivating mutations in human acute megakaryoblastic leukemia
Malinge, S., Ragu, C., Della-Valle, V., Pisani, D. F., Constantinescu, S. N., Pérez, C., Villeval, J., Reinhardt, D., Landman‐Parker, J., Michaux, L., et al. (2008) · Blood · doi:10.1182/blood-2008-01-136366 · Cited by 145 · see citing works
Ascani, S., Zinzani, P. L., Gherlinzoni, F., et al. (1997) · Annals of Oncology · doi:10.1023/a:1008200307625 · Cited by 136 · see citing works
Epstein-Barr Virus LMP1 Activates EGFR, STAT3, and ERK through Effects on PKCδ
Kung, C.-P., Meckes, D., & Raab-Traub, N. (2011) · Journal of Virology · doi:10.1128/jvi.01703-10 · Cited by 136 · see citing works
Frequent BCOR aberrations in extranodal NK/T ‐Cell lymphoma, nasal type
Dobashi, A., Tsuyama, N., Asaka, R., Togashi, Y., Ueda, K., Sakata, S., Baba, S., Sakamoto, K., Hatake, K., & Takeuchi, K. (2016) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22348 · Cited by 131 · see citing works
Coppo, P., Gouilleux‐Gruart, V., Huang, Y., Bouhlal, H., Bouamar, H., Bouchet, S., Perrot, C., Vieillard, V., Dartigues, P., Gaulard, P., et al. (2009) · Leukemia · doi:10.1038/leu.2009.91 · Cited by 113 · see citing works
Jo, J., Kim, M., Choi, Y., et al. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2818-4 · Cited by 110 · see citing works
Mutations in the JAK/STAT and RAS signaling pathways are common in intestinal T-cell lymphomas
Nicolae, A., Xi, L., Pham, T. H., et al. (2016) · Leukemia · doi:10.1038/leu.2016.178 · Cited by 97 · see citing works
Mutations in the signal transducer and activator of transcription family of genes in cancer
Shahmarvand, N., Nagy, A., Shahryari, J., et al. (2018) · Cancer Science · doi:10.1111/cas.13525 · Cited by 85 · see citing works
Kim, W. Y., Jung, H. Y., Nam, S. J., Kim, T. M., Heo, D. S., Kim, C. W., & Jeon, Y. K. (2016) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-016-2011-0 · Cited by 82 · see citing works
Wang, W., Yen, M., Liu, K., Hsu, P., Sytwu, H., Chen, P., Sudhir, P., Chen, C., Chen, C., Hk, S., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.07.013 · Cited by 80 · see citing works
Schatz, J., Horwitz, S., Teruya-Feldstein, J., Lunning, M., Viale, A., Huberman, K., Socci, N., Lailler, N., Heguy, A., Dolgalev, I., et al. (2014) · Leukemia · doi:10.1038/leu.2014.261 · Cited by 75 · see citing works
Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia
Andersson, E. I., Kuusanmäki, H. A., Bortoluzzi, S., et al. (2015) · Leukemia · doi:10.1038/leu.2015.263 · Cited by 74 · see citing works
Pérez, C., González‐Rincón, J., Onaindía, A., Almaráz, C., García‐Díaz, N., Pisonero, H., Curiel‐Olmo, S., Gómez, S., Cereceda, L., Madureira, R., et al. (2015) · Haematologica · doi:10.3324/haematol.2015.132837 · Cited by 73 · see citing works
Bang, Y., Muro, K., Fuchs, C. S., Golan, T., Geva, R., Hara, H., Jalal, S. I., Borg, C., Doi, T., Wainberg, Z. A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.4012 · Cited by 73 · see citing works
Couronné, L., Scourzic, L., Pilati, C., et al. (2013) · Haematologica · doi:10.3324/haematol.2013.085068 · Cited by 56 · see citing works
Novel JAK3-Activating Mutations in Extranodal NK/T-Cell Lymphoma, Nasal Type
Sim, S. H., Kim, S., Kim, T. M., Jeon, Y. K., Nam, S. J., Ahn, Y., Keam, B., Park, H. H., Kim, D., Kim, C. W., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.01.004 · Cited by 55 · see citing works
Oncogenic role of miR ‐155 in anaplastic large cell lymphoma lacking the t(2;5) translocation
Merkel, O., Hamacher, F., Griessl, R., Grabner, L., Schiefer, A., Prutsch, N., Baer, C. R., Egger, G., Schlederer, M., Krenn, P. W., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4539 · Cited by 54 · see citing works
Han, L., Liu, F., Li, R., Li, Z., Chen, X., ZHOU, Z., Zhang, X., Hu, T., Zhang, Y., Young, K. H., et al. (2014) · Oncology Letters · doi:10.3892/ol.2014.2356 · Cited by 52 · see citing works
Self-citationp53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma
Rassidakis, G. Z., Thomaides, A. X., Wang, S., Jiang, Y., Fourtouna, A., Lai, R., & Medeiros, L. J. (2005) · Leukemia · doi:10.1038/sj.leu.2403840 · Cited by 52 · see citing works
Chong, L. C., Twa, D. D. W., Mottok, A., et al. (2016) · Blood · doi:10.1182/blood-2015-11-683003 · Cited by 52 · see citing works
Nabhani, S., Schipp, C., Miskin, H., Levin, C., Postovsky, S., Dujovny, T., Koren, A., Harlev, D., Bis, A.-M., Auer, F., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.05.021 · Cited by 51 · see citing works
SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients
Schif, B., Lennerz, J. K., Kohler, C. W., Bentink, S., Kreuz, M., Melzner, I., Ritz, O., Trümper, L. H. P., Loeffler, M., Spang, R., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.774 · Cited by 49 · see citing works
Fazil, M. H. U. T., Ong, S. T., Chalasani, M. L. S., et al. (2016) · Scientific Reports · doi:10.1038/srep37721 · Cited by 47 · see citing works
Phenotypic analysis of peripheral T cell lymphoma among the Japanese
Nakamura, S., Koshikawa, T., Koike, K., et al. (1993) · Acta Pathologica Japonica · doi:10.1111/j.1440-1827.1993.tb01151.x · Cited by 44 · see citing works
Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera
Tsuruta-Kishino, T., Koya, J., Kataoka, K., Narukawa, K., Sumitomo, Y., Kobayashi, H., Sato, T., & Kurokawa, M. (2017) · Oncogene · doi:10.1038/onc.2016.478 · Cited by 41 · see citing works
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2
Ren, Z., Aerts, J. L., Vandenplas, H., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.430 · Cited by 39 · see citing works
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, K., Behrmann, I., & Haan, C. (2013) · JAK-STAT · doi:10.4161/jkst.25025 · Cited by 38 · see citing works
Lai, J., Xu, P., Jiang, X.-L., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3501-4 · Cited by 27 · see citing works
Jo, J., Choi, Y., Cha, H. J., et al. (2015) · Blood · doi:10.1182/blood.v126.23.1461.1461 · Cited by 26 · see citing works
Manso, R., Sánchez‐Beato, M., González‐Rincón, J., et al. (2017) · British Journal of Haematology · doi:10.1111/bjh.14984 · Cited by 24 · see citing works
Ehrentraut, S., Schneider, B., Nagel, S., Pommerenke, C., Quentmeier, H., Geffers, R., Feist, M., Kaufmann, M., Meyer, C., Kadin, M. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9077 · Cited by 22 · see citing works
STAT 3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice
Dutta, A., Yan, D., Hutchison, R. E., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.14487 · Cited by 22 · see citing works
Martinez, G. S., Ross, J. A., & Kirken, R. A. (2016) · Clinical Cancer Drugs · doi:10.2174/2212697x03666160610085943 · Cited by 20 · see citing works
An Epstein-Barr virus positive natural killer lymphoma xenograft derived for drug testing
Loong, S. L. E., Hwang, J. S. G., Lim, S.-T., et al. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190802043879 · Cited by 11 · see citing works
Self-citationBarth, T. F. E., Melzner, I., Wegener, S., Bucur, A. J., Brüderlein, S., Dorsch, K., Hasel, C., Leithäuser, F., & Møller, P. (2005) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of PD-L1 expression in the tumor microenvironment
Yi, M., Niu, M., Xu, L., Luo, S., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01027-5 · Cited by 681 · see citing works
Yi, M., Zhang, J., Li, A., Niu, M., Yan, Y., Jiao, Y., Luo, S., Zhou, P., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01045-x · Cited by 233 · see citing works
Li, Q., Zhang, L., You, W., Xu, J., Dai, J., Hua, D., Zhang, R., Yao, F., Zhou, S., Huang, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35469-x · Cited by 128 · see citing works
- Authors
- Song, T. L., Nairismägi, M.-L., Laurensia, Y., Lim, J.-Q., Tan, J., Li, Z.-M., Pang, W.-L., Kizhakeyil, A., Wijaya, G.-C., Huang, D.-C., Nagarajan, S., Chia, B. K.-H., Cheah, D., Liu, Y.-H., Zhang, F., Rao, H.-L., Tang, T., Wong, E. K.-Y., Bei, J.-X., Iqbal, J., Grigoropoulos, N.-F., Ng, S.-B., Chng, W.-J., Teh, B.-T., Tan, S.-Y., Verma, N. K., Fan, H., Lim, S.-T., & Ong, C.-K.
- Affiliations
- Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, and
- Sun Yat-sen University (CN)
- National Cancer Centre Singapore (SG)
- Nanyang Technological University (SG)
- Guangdong General Hospital (CN)
- National University of Singapore (SG)
- Singapore General Hospital (SG)
- National University Hospital (SG)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Song, Tammy Linlin
- Nairismägi, Maarja-Liisa
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-09-13
- Volume
- 132
- Issue
- 11
- Pages
- 1146-1158
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6148343
- OpenAlex
- W2622400061
- Cited by
- 326
- References
- 84
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 36 · 2023: 45 · 2022: 46 · 2021: 59 · 2020: 48 · 2019: 23 · 2018: 5
- FWCI
- 26.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- National Cancer Centre of Singapore
- Duke-NUS Medical School
- Tanoto Foundation
- Singapore General Hospital
- Nanyang Technological University
- Sun Yat-sen University
- Medical Research Council
- National Medical Research Council
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Biomedical Research Council
- Sun Yat-sen University Cancer Center
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- STAT3 activation, PD-L1 expression, natural killer/T-cell lymphoma, tumor immune evasion, PD-1/PD-L1 blockade, STAT3 inhibitor, primary T-cell lymphoma, oncogenic signaling
- MeSH terms
- Humans, Neoplasm Proteins, Signal Transduction, Gene Expression Regulation, Neoplastic, Amino Acid Substitution, Mutation, Missense, Cell Line, Tumor, STAT3 Transcription Factor, Lymphoma, Extranodal NK-T-Cell, B7-H1 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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