Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

SEARCH; Ahmed, Shahana; The GENICA Consortium; kConFab; Australian Ovarian Cancer Study Group; Thomas, Gilles; Ghoussaini, Maya; Healey, Catherine S; Humphreys, Manjeet K; Platte, Radka; Morrison, Jonathan; Maranian, Melanie; Pooley, Karen A; Luben, Robert; Eccles, Diana; Evans, D Gareth; Fletcher, Olivia; Johnson, Nichola; dos Santos Silva, Isabel; Peto, Julian; Stratton, Michael R; Rahman, Nazneen; Jacobs, Kevin; Prentice, Ross; Anderson, Garnet L; Rajkovic, Aleksandar; Curb, J David; Ziegler, Regina G; Berg, Christine D; Buys, Saundra S; McCarty, Catherine A; Feigelson, Heather Spencer; Calle, Eugenia E; Thun, Michael J; Diver, W Ryan; Bojesen, Stig; Nordestgaard, Børge G; Flyger, Henrik; Dörk, Thilo; Schürmann, Peter; Hillemanns, Peter; Karstens, Johann H; Bogdanova, Natalia V; Antonenkova, Natalia N; Zalutsky, Iosif V; Bermisheva, Marina; Fedorova, Sardana; Khusnutdinova, Elza; Kang, Daehee; Yoo, Keun-Young

doi:10.1038/ng.354

Cited by 477

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Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

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SEARCH, Ahmed, Shahana, The GENICA Consortium, kConFab, Australian Ovarian Cancer Study Group, Thomas, Gilles, Ghoussaini, Maya, Healey, Catherine S, Humphreys, Manjeet K, Platte, Radka, Morrison, Jonathan, Maranian, Melanie, Pooley, Karen A, Luben, Robert, Eccles, Diana, Evans, D Gareth, Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Peto, Julian, Stratton, Michael R, Rahman, Nazneen, Jacobs, Kevin, Prentice, Ross, Anderson, Garnet L, Rajkovic, Aleksandar, Curb, J David, Ziegler, Regina G, Berg, Christine D, Buys, Saundra S, McCarty, Catherine A, Feigelson, Heather Spencer, Calle, Eugenia E, Thun, Michael J, Diver, W Ryan, Bojesen, Stig, Nordestgaard, Børge G, Flyger, Henrik, Dörk, Thilo, Schürmann, Peter, Hillemanns, Peter, Karstens, Johann H, Bogdanova, Natalia V, Antonenkova, Natalia N, Zalutsky, Iosif V, Bermisheva, Marina, Fedorova, Sardana, Khusnutdinova, Elza, Kang, Daehee, Yoo, Keun-Young, Noh, Dong Young, Ahn, Sei-Hyun, Devilee, Peter, van Asperen, Christi J, Tollenaar, R A E M, Seynaeve, Caroline, Garcia-Closas, Montserrat, Lissowska, Jolanta, Brinton, Louise, Peplonska, Beata, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Hopper, John L, Southey, Melissa C, Smith, Letitia, Spurdle, Amanda B, Schmidt, Marjanka K, Broeks, Annegien, van Hien, Richard R, Cornelissen, Sten, Milne, Roger L, Ribas, Gloria, González-Neira, Anna, Benitez, Javier, Schmutzler, Rita K, Burwinkel, Barbara, Bartram, Claus R, Meindl, Alfons, Brauch, Hiltrud, Justenhoven, Christina, Hamann, Ute, Chang-Claude, Jenny, Hein, Rebecca, Wang-Gohrke, Shan, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Olson, Janet E, Wang, Xianshu, Fredericksen, Zachary, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, English, Dallas R, Hankinson, Susan E, Cox, David G, Kraft, Peter, Vatten, Lars J, Hveem, Kristian, Kumle, Merethe, Sigurdson, Alice, Doody, Michele, Bhatti, Parveen, Alexander, Bruce H, Hooning, Maartje J, van den Ouweland, Ans M W, Oldenburg, Rogier A, Schutte, Mieke, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Yuqing, Cox, Angela, Elliott, Graeme, Brock, Ian, Reed, Malcolm W R, Shen, Chen-Yang, Yu, Jyh-Cherng, Hsu, Giu-Cheng, Chen, Shou-Tung, Anton-Culver, Hoda, Ziogas, Argyrios, Andrulis, Irene L, Knight, Julia A, Beesley, Jonathan, Goode, Ellen L, Couch, Fergus, Chenevix-Trench, Georgia, Hoover, Robert N, Ponder, Bruce A J, Hunter, David J, Pharoah, Paul D P, Dunning, Alison M, Chanock, Stephen J, Easton, Douglas F·2009·Nature Genetics

DOI 10.1038/ng.354

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Abstract

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 × 10−23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 × 10−8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.

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Authors: SEARCH, Ahmed, S., The GENICA Consortium, kConFab, Australian Ovarian Cancer Study Group, Thomas, G., Ghoussaini, M., Healey, C. S., Humphreys, M. K., Platte, R., Morrison, J., Maranian, M., Pooley, K. A., Luben, R., Eccles, D., Evans, D. G., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Stratton, M. R., Rahman, N., Jacobs, K., Prentice, R., Anderson, G. L., Rajkovic, A., Curb, J. D., Ziegler, R. G., Berg, C. D., Buys, S. S., McCarty, C. A., Feigelson, H. S., Calle, E. E., Thun, M. J., Diver, W. R., Bojesen, S., Nordestgaard, B. G., Flyger, H., Dörk, T., Schürmann, P., Hillemanns, P., Karstens, J. H., Bogdanova, N. V., Antonenkova, N. N., Zalutsky, I. V., Bermisheva, M., Fedorova, S., Khusnutdinova, E., Kang, D., Yoo, K.-Y., Noh, D. Y., Ahn, S.-H., Devilee, P., van Asperen, C. J., Tollenaar, R. A. E. M., Seynaeve, C., Garcia-Closas, M., Lissowska, J., Brinton, L., Peplonska, B., Nevanlinna, H., Heikkinen, T., Aittomäki, K., Blomqvist, C., Hopper, J. L., Southey, M. C., Smith, L., Spurdle, A. B., Schmidt, M. K., Broeks, A., van Hien, R. R., Cornelissen, S., Milne, R. L., Ribas, G., González-Neira, A., Benitez, J., Schmutzler, R. K., Burwinkel, B., Bartram, C. R., Meindl, A., Brauch, H., Justenhoven, C., Hamann, U., Chang-Claude, J., Hein, R., Wang-Gohrke, S., Lindblom, A., Margolin, S., Mannermaa, A., Kosma, V.-M., Kataja, V., Olson, J. E., Wang, X., Fredericksen, Z., Giles, G. G., Severi, G., Baglietto, L., English, D. R., Hankinson, S. E., Cox, D. G., Kraft, P., Vatten, L. J., Hveem, K., Kumle, M., Sigurdson, A., Doody, M., Bhatti, P., Alexander, B. H., Hooning, M. J., van den Ouweland, A. M. W., Oldenburg, R. A., Schutte, M., Hall, P., Czene, K., Liu, J., Li, Y., Cox, A., Elliott, G., Brock, I., Reed, M. W. R., Shen, C.-Y., Yu, J.-C., Hsu, G.-C., Chen, S.-T., Anton-Culver, H., Ziogas, A., Andrulis, I. L., Knight, J. A., Beesley, J., Goode, E. L., Couch, F., Chenevix-Trench, G., Hoover, R. N., Ponder, B. A. J., Hunter, D. J., Pharoah, P. D. P., Dunning, A. M., Chanock, S. J., & Easton, D. F.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-03-29
Volume: 41
Issue: 5
Pages: 585-590
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng.354
OpenAlex: W2064041354
Cited by: 477
References: 12
FWCI: 38.50
Type: journal article
Language: en
Open access: green

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This page: CoChat. (2026). Citation check: Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. https://app.cochat.ai/papers/10.1038/ng.354
The paper: SEARCH, Ahmed, S., The GENICA Consortium, kConFab, Australian Ovarian Cancer Study Group, Thomas, G., Ghoussaini, M., Healey, C. S., Humphreys, M. K., Platte, R., Morrison, J., Maranian, M., Pooley, K. A., Luben, R., Eccles, D., Evans, D. G., Fletcher, O., Johnson, N., dos Santos Silva, I., . . . Easton, D. F. (2009). Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nature Genetics. https://doi.org/10.1038/ng.354

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Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

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