The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Common variants at ten loci influence QT interval duration in the QTGEN Study
Open accessAbstract
QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a heritable risk factor for sudden cardiac death and drug-induced arrhythmias. We conducted a meta-analysis of three genome-wide association studies in 13,685 individuals of European ancestry from the Framingham Heart Study, the Rotterdam Study and the Cardiovascular Health Study, as part of the QTGEN consortium. We observed associations at P < 5 × 10−8 with variants in NOS1AP, KCNQ1, KCNE1, KCNH2 and SCN5A, known to be involved in myocardial repolarization and mendelian long-QT syndromes. Associations were found at five newly identified loci, including 16q21 near NDRG4 and GINS3, 6q22 near PLN, 1p36 near RNF207, 16p13 near LITAF and 17q12 near LIG3 and RFFL. Collectively, the 14 independent variants at these 10 loci explain 5.4–6.5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias.
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Cites
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Self-citationGenomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 1×
“Heart rate (beats/minute) 67 (13) 72 (14) 68 (12) 71 (12) 66 (11) 69 (10)”
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · cited 1×
“The ratio of the observed to the expected variance of the imputed allele frequency was used as the quality metric for the imputation of a given SN”
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Cited by
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761
Self-citationNitric oxide signalling in cardiovascular health and disease
Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779
Khalil, M., Pirpamer, L., Hofer, E., Voortman, M. M., Barro, C., Leppert, D., Benkert, P., Ropele, S., Enzinger, C., Fazekas, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14612-6 · Cited by 572
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531
Metadata
- Authors
- Newton-Cheh, C., Eijgelsheim, M., Rice, K. M., de Bakker, P. I. W., Yin, X., Estrada, K., Bis, J. C., Marciante, K., Rivadeneira, F., Noseworthy, P. A., Sotoodehnia, N., Smith, N. L., Rotter, J. I., Kors, J. A., Witteman, J. C. M., Hofman, A., Heckbert, S. R., O'Donnell, C. J., Uitterlinden, A. G., Psaty, B. M., Lumley, T., Larson, M. G., & Ch Stricker, B. H.
- Venue
- Nature Genetics
- Published
- 2009-03-22
- Volume
- 41
- Issue
- 4
- Pages
- 399-406
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2119494804
- Cited by
- 413
- References
- 4
- FWCI
- 31.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Newton-Cheh, C., Eijgelsheim, M., Rice, K. M., de Bakker, P. I. W., Yin, X., Estrada, K., Bis, J. C., Marciante, K., Rivadeneira, F., Noseworthy, P. A., Sotoodehnia, N., Smith, N. L., Rotter, J. I., Kors, J. A., Witteman, J. C. M., Hofman, A., Heckbert, S. R., O'Donnell, C. J., Uitterlinden, A. G., . . . Ch Stricker, B. H. (2009). Common variants at ten loci influence QT interval duration in the QTGEN Study. Nature Genetics. https://doi.org/10.1038/ng.364
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