The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Clonal evolution of chemotherapy-resistant urothelial carcinoma
Open accessAbstract
Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, including 16 matched sets of primary and advanced tumors prospectively collected before and after chemotherapy. Our analysis provided several insights: (i) chemotherapy-treated urothelial carcinoma is characterized by intra-patient mutational heterogeneity, and the majority of mutations are not shared; (ii) both branching evolution and metastatic spread are very early events in the natural history of urothelial carcinoma; (iii) chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell adhesion molecule (L1CAM) and integrin signaling pathways; and (iv) APOBEC-induced mutagenesis is clonally enriched in chemotherapy-treated urothelial carcinoma and continues to shape the evolution of urothelial carcinoma throughout its lifetime.
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Cites
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Cited by
Tumour heterogeneity and resistance to cancer therapies
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Clonal heterogeneity and tumor evolution: past, present, and the future
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Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer
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Metal Drugs and the Anticancer Immune Response
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Metadata
- Authors
- Faltas, B. M., Prandi, D., Tagawa, S. T., Molina, A. M., Nanus, D. M., Sternberg, C., Rosenberg, J., Mosquera, J. M., Robinson, B., Elemento, O., Sboner, A., Beltran, H., Demichelis, F., & Rubin, M. A.
- Venue
- Nature Genetics
- Published
- 2016-10-17
- Volume
- 48
- Issue
- 12
- Pages
- 1490-1499
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2533194337
- Cited by
- 294
- References
- 64
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Faltas, B. M., Prandi, D., Tagawa, S. T., Molina, A. M., Nanus, D. M., Sternberg, C., Rosenberg, J., Mosquera, J. M., Robinson, B., Elemento, O., Sboner, A., Beltran, H., Demichelis, F., & Rubin, M. A. (2016). Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nature Genetics. https://doi.org/10.1038/ng.3692
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