The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
Open accessAbstract
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expression and often have neuroendocrine features. The etiology and molecular basis for this 'alternative' treatment-resistant cell state remain incompletely understood. Here, by analyzing whole-exome sequencing data of metastatic biopsies from patients, we observed substantial genomic overlap between castration-resistant tumors that were histologically characterized as prostate adenocarcinomas (CRPC-Adeno) and neuroendocrine prostate cancer (CRPC-NE); analysis of biopsy samples from the same individuals over time points to a model most consistent with divergent clonal evolution. Genome-wide DNA methylation analysis revealed marked epigenetic differences between CRPC-NE tumors and CRPC-Adeno, and also designated samples of CRPC-Adeno with clinical features of AR independence as CRPC-NE, suggesting that epigenetic modifiers may play a role in the induction and/or maintenance of this treatment-resistant state. This study supports the emergence of an alternative, 'AR-indifferent' cell state through divergent clonal evolution as a mechanism of treatment resistance in advanced prostate cancer.
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Self-citationAbiraterone and Increased Survival in Metastatic Prostate Cancer
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Self-citationAR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
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Self-citationAndrogen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling
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Cellular plasticity and the neuroendocrine phenotype in prostate cancer
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Metadata
- Authors
- Beltran, H., Prandi, D., Mosquera, J. M., Benelli, M., Puca, L., Cyrta, J., Marotz, C., Giannopoulou, E., Chakravarthi, B. V. S. K., Varambally, S., Tomlins, S. A., Nanus, D. M., Tagawa, S. T., Van Allen, E. M., Elemento, O., Sboner, A., Garraway, L. A., Rubin, M. A., & Demichelis, F.
- Venue
- Nature Medicine
- Published
- 2016-02-08
- Volume
- 22
- Issue
- 3
- Pages
- 298-305
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2262087934
- Cited by
- 1,685
- References
- 11
- FWCI
- 130.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Beltran, H., Prandi, D., Mosquera, J. M., Benelli, M., Puca, L., Cyrta, J., Marotz, C., Giannopoulou, E., Chakravarthi, B. V. S. K., Varambally, S., Tomlins, S. A., Nanus, D. M., Tagawa, S. T., Van Allen, E. M., Elemento, O., Sboner, A., Garraway, L. A., Rubin, M. A., & Demichelis, F. (2016). Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nature Medicine. https://doi.org/10.1038/nm.4045
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
