Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella +24 more·2017·Nature Genetics

DOI 10.1038/ng.3722

Cited by (423)

Items 301–400 of 423

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Disruption of the topological associated domain at Xp21.2 is related to gonadal dysgenesis: A general mechanism of pathogenesis
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Epigenetic Rewiring of Enhancer–Promoter Interactions in Cancer: Mechanisms and Therapeutic Implications
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InterTADs: Integration of Multi-Omics Data on Topological Associated Domains
Maria Tsagiopoulou, Nikolaos Pechlivanis, Fotis E Psomopoulos · 2020 · Research Square
CTCF zinc finger mutations produce cellular phenotypes explained by structure-function relationships
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Additional file 2 of Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
Marie Zufferey, Yuanlong Liu, Daniele Tavernari, Marco Mina, Giovanni Ciriello · 2021 · Figshare
Additional file 3 of Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
Marie Zufferey, Yuanlong Liu, Daniele Tavernari, Marco Mina, Giovanni Ciriello · 2021 · Figshare
Additional file 4 of Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
Marie Zufferey, Yuanlong Liu, Daniele Tavernari, Marco Mina, Giovanni Ciriello · 2021 · Figshare
Additional file 1 of Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation
Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman · 2023 · Figshare
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Additional file 2 of Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation
Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman · 2024 · Figshare
Additional file 9 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Mari Masuda, Adachi, Shungo et al. · 2024 · Figshare
Additional file 5 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Peng Li, Leonard, Warren J. · 2024 · Figshare
Additional file 2 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Peng Li, Leonard, Warren J. · 2024 · Figshare
Additional file 2 of Giant pandas in captivity undergo short-term adaptation in nerve-related pathways
Li, Yan, Wei Xu, Wang, Juan, Liu, Hong, Jiawen Liu, Liang Zhang, Rong Hou, 沈富军, Liu, Yuliang, Cai, Kailai · 2024 · Figshare
Additional file 4 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Peng Li, Leonard, Warren J. · 2024 · Figshare
Additional file 2 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 10 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Mari Masuda, Adachi, Shungo et al. · 2024 · Figshare
Additional file 6 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 4 of Giant pandas in captivity undergo short-term adaptation in nerve-related pathways
Yán Li, Xu, Wei, Wang, Juan, Liu, Hong, Jiawen Liu, Liang Zhang, Rong Hou, 沈富军, Liu, Yuliang, Cai, Kailai · 2024 · Figshare
Additional file 4 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 5 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 11 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Mari Masuda, Adachi, Shungo et al. · 2024 · Figshare
Additional file 3 of SVFX: a machine learning framework to quantify the pathogenicity of structural variants
Kumar, Sushant, Arif O. Harmanci, Jagath Vytheeswaran, Mark Gerstein · 2020 · Figshare
Additional file 1 of Giant pandas in captivity undergo short-term adaptation in nerve-related pathways
Li, Yan, Xu, Wei, Wang, Juan, Hong Liu, Jiawen Liu, Liang Zhang, Rong Hou, 沈富军, Liu, Yuliang, Cai, Kailai · 2024 · Figshare
Additional file 3 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Li, Peng, Leonard, Warren J. · 2024 · Figshare
Additional file 4 of Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation
Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman · 2024 · Figshare
Additional file 7 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 8 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 6 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Peng Li, Leonard, Warren J. · 2024 · Figshare
Additional file 5 of Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
Marie Zufferey, Liu, Yuanlong, Daniele Tavernari, Mina, Marco, Giovanni Ciriello · 2021 · Figshare
Additional file 2 of SVFX: a machine learning framework to quantify the pathogenicity of structural variants
Kumar, Sushant, Arif O. Harmanci, Jagath Vytheeswaran, Mark Gerstein · 2020 · Figshare
Additional file 1 of Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Syuzo Kaneko, Ken Takasawa, Ken Asada, Shiraishi, Kouya, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Masuda, Mari, Adachi, Shungo et al. · 2024 · Figshare
Additional file 1 of Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
Marie Zufferey, Liu, Yuanlong, Daniele Tavernari, Mina, Marco, Giovanni Ciriello · 2021 · Figshare
Additional file 6 of Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation
Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman · 2024 · Figshare
Additional file 1 of Co-localization of clusters of TCR-regulated genes with TAD rearrangements
Gao, Galen F., Peng Li, Leonard, Warren J. · 2023 · Figshare
Additional file 3 of Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation
Yifat Edrei, Revital Levy, Daniel Kaye, Anat Marom, Bernhard Radlwimmer, Asaf Hellman · 2024 · Figshare