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Cited by 422

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Dynamics of clonal evolution in myelodysplastic syndromes

Open access
Makishima, Hideki, Yoshizato, Tetsuichi, Yoshida, Kenichi, Sekeres, Mikkael A, Radivoyevitch, Tomas, Suzuki, Hiromichi, Przychodzen, Bartlomiej, Nagata, Yasunobu, Meggendorfer, Manja, Sanada, Masashi, Okuno, Yusuke, Hirsch, Cassandra, Kuzmanovic, Teodora, Sato, Yusuke, Sato-Otsubo, Aiko, LaFramboise, Thomas, Hosono, Naoko, Shiraishi, Yuichi, Chiba, Kenichi, Haferlach, Claudia, Kern, Wolfgang, Tanaka, Hiroko, Shiozawa, Yusuke, Gómez-Seguí, Inés, Husseinzadeh, Holleh D, Thota, Swapna, Guinta, Kathryn M, Dienes, Brittney, Nakamaki, Tsuyoshi, Miyawaki, Shuichi, Saunthararajah, Yogen, Chiba, Shigeru, Miyano, Satoru, Shih, Lee-Yung, Haferlach, Torsten, Ogawa, Seishi, Maciejewski, Jaroslaw P·2017·Nature Genetics
DOI 10.1038/ng.3742
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Abstract

To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 patients, of whom 122 were analyzed longitudinally. Including the results from previous reports, we assessed a total of 2,250 patients for mutational enrichment patterns. During progression, the number of mutations, their diversity and clone sizes increased, with alterations frequently present in dominant clones with or without their sweeping previous clones. Enriched in secondary acute myeloid leukemia (sAML; in comparison to high-risk MDS), FLT3, PTPN11, WT1, IDH1, NPM1, IDH2 and NRAS mutations (type 1) tended to be newly acquired, and were associated with faster sAML progression and a shorter overall survival time. Significantly enriched in high-risk MDS (in comparison to low-risk MDS), TP53, GATA2, KRAS, RUNX1, STAG2, ASXL1, ZRSR2 and TET2 mutations (type 2) had a weaker impact on sAML progression and overall survival than type-1 mutations. The distinct roles of type-1 and type-2 mutations suggest their potential utility in disease monitoring.

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Metadata

Authors
Makishima, H., Yoshizato, T., Yoshida, K., Sekeres, M. A., Radivoyevitch, T., Suzuki, H., Przychodzen, B., Nagata, Y., Meggendorfer, M., Sanada, M., Okuno, Y., Hirsch, C., Kuzmanovic, T., Sato, Y., Sato-Otsubo, A., LaFramboise, T., Hosono, N., Shiraishi, Y., Chiba, K., Haferlach, C., Kern, W., Tanaka, H., Shiozawa, Y., Gómez-Seguí, I., Husseinzadeh, H. D., Thota, S., Guinta, K. M., Dienes, B., Nakamaki, T., Miyawaki, S., Saunthararajah, Y., Chiba, S., Miyano, S., Shih, L.-Y., Haferlach, T., Ogawa, S., & Maciejewski, J. P.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2016-12-19
Volume
49
Issue
2
Pages
204-212
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.3742
OpenAlex
W2561161989
Cited by
422
References
19
FWCI
35.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dynamics of clonal evolution in myelodysplastic syndromes. https://app.cochat.ai/papers/10.1038/ng.3742
The paper
Makishima, H., Yoshizato, T., Yoshida, K., Sekeres, M. A., Radivoyevitch, T., Suzuki, H., Przychodzen, B., Nagata, Y., Meggendorfer, M., Sanada, M., Okuno, Y., Hirsch, C., Kuzmanovic, T., Sato, Y., Sato-Otsubo, A., LaFramboise, T., Hosono, N., Shiraishi, Y., Chiba, K., . . . Maciejewski, J. P. (2017). Dynamics of clonal evolution in myelodysplastic syndromes. Nature Genetics. https://doi.org/10.1038/ng.3742

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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